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  • 11(13)-去氢腋生依瓦菊素

    11(13)-Dehydroivaxillin

    11(13)-去氢腋生依瓦菊素
    产品编号 CFN97438
    CAS编号 87441-73-4
    分子式 = 分子量 C15H20O4 = 264.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Carpesium abrotanoides L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    11(13)-去氢腋生依瓦菊素 CFN97438 87441-73-4 1mg QQ客服:215959384
    11(13)-去氢腋生依瓦菊素 CFN97438 87441-73-4 5mg QQ客服:215959384
    11(13)-去氢腋生依瓦菊素 CFN97438 87441-73-4 10mg QQ客服:215959384
    11(13)-去氢腋生依瓦菊素 CFN97438 87441-73-4 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Wageningen University (Netherlands)
  • University of the Basque Country (Spain)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Kitasato University (Japan)
  • Amity University (India)
  • Mahatma Gandhi University (India)
  • Institute of Chinese Materia Medica (China)
  • University of Pretoria (South Africa)
  • Florida A&M University (USA)
  • Monash University Malaysia (Malaysia)
  • The University of Newcastle (Australia)
  • University of Madras (India)
  • Mahidol University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • Plant Cell, Tissue and Organ Culture (PCTOC)2020, 143, 45-60(2020)
  • Industrial Crops and Products2022, 186:115298
  • Evid Based Complement Alternat Med.2021, 2021:8707280.
  • Front Microbiol.2021, 12:736780.
  • Pharmacogn J.2022, 14(2):350-357
  • Life Sci.2022, 298:120488.
  • J Nat Med.2017, 71(4):745-756
  • J Anal Toxicol.2021, bkab015.
  • J Agric Food Chem.2020, 68(43):12164-12172.
  • Nat Commun.2019, 10(1):2745
  • J Mass Spectrom.2022, 57(2):e4810.
  • Industrial Crops and Products2019, 140:111612
  • Molecules.2021, 26(4):816.
  • Int J Mol Sci.2021, 22(14):7324.
  • Indian J. of Experimental Bio.2020, 9(58).
  • Food Chem Toxicol.2020, 135:110863
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • Appl. Sci.2020, 10,1304
  • J Ethnopharmacol.2020, 260:112988.
  • Antioxidants2022, 11(2),234.
  • Vietnam J. Chemistry2022, 60(2):211-222
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • ...
  • 生物活性
    Description: 11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
    Targets: Antifection
    In vivo:
    J Enzyme Inhib Med Chem. 2009 Feb;24(1):247-50.
    In vivo antiplasmodial activity of 11(13)-dehydroivaxillin from Carpesium ceruum.[Pubmed: 18608780]
    The whole plants of Carpesium genus are used in traditional medicine as anti-pyretic, analgesic and vermifugic, including a topical application for sores and inflammation. A previous study on Carpesium genus suggested that the antiplasmodial activity against Plasmodium falciparum was due to the existence of 11(13)-Dehydroivaxillin (DDV) from EtOAc extracts of C. ceruum (Compositae).
    METHODS AND RESULTS:
    Here, the antimalarial activity of 11(13)-Dehydroivaxillin was evaluated against Plasmodium berghei in mice. The LD(50) of the compound was determined as 51.2 mg/kg, while doses of 124 mg/kg and above were found to be lethal to mice. 11(13)-Dehydroivaxillin (2, 5, 10 mg/kg/day) exhibited a significant blood schizontocidal activity in 4-day early infection, repository evaluation and in an established infection with a significant mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day.
    CONCLUSIONS:
    11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7836 mL 18.9179 mL 37.8358 mL 75.6716 mL 94.5895 mL
    5 mM 0.7567 mL 3.7836 mL 7.5672 mL 15.1343 mL 18.9179 mL
    10 mM 0.3784 mL 1.8918 mL 3.7836 mL 7.5672 mL 9.4589 mL
    50 mM 0.0757 mL 0.3784 mL 0.7567 mL 1.5134 mL 1.8918 mL
    100 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.7567 mL 0.9459 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Carabrolactone A; Carabrolactone A CFN99286 1187925-30-9 C15H22O5 = 282.3 5mg QQ客服:215959384
    11(13)-去氢腋生依瓦菊素; 11(13)-Dehydroivaxillin CFN97438 87441-73-4 C15H20O4 = 264.3 5mg QQ客服:1413575084
    Aeruginolactone; Aeruginolactone CFN92791 1005208-88-7 C15H20O3 = 248.3 5mg QQ客服:3257982914
    野马追内酯O; Eupalinolide O CFN91839 2170228-67-6 C22H26O8 = 418.4 5mg QQ客服:1413575084
    野马追内酯A; Eupalinolide A CFN90381 877822-41-8 C24H30O9 = 462.49 20mg QQ客服:2056216494
    野马追内酯B; Eupalinolide B CFN90382 877822-40-7 C24H30O9 = 462.49 20mg QQ客服:2159513211
    野马追内酯K; Eupalinolide K CFN99435 108657-10-9 C20H26O6 = 362.4 10mg QQ客服:1457312923
    4,15-Isoatriplicolide methylacrylate; 4,15-Isoatriplicolide methylacrylate CFN92956 133559-38-3 C19H20O6 = 344.36 5mg QQ客服:1457312923
    Isoatriplicolide tiglate; Isoatriplicolide tiglate CFN92955 133559-39-4 C20H22O6 = 358.39 5mg QQ客服:215959384

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