刺凌德草碱

Echinatine

	产品编号	CFN00255
	CAS编号	480-83-1
	分子式 = 分子量	C₁₅H₂₅NO₅ = 299.37
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Alkaloids
	植物来源	The herbs of Eupatorium cannabinum L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
刺凌德草碱	CFN00255	480-83-1	1mg	QQ客服：1457312923
刺凌德草碱	CFN00255	480-83-1	5mg	QQ客服：1457312923
刺凌德草碱	CFN00255	480-83-1	10mg	QQ客服：1457312923
刺凌德草碱	CFN00255	480-83-1	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Chulalongkorn University (Thailand)

University of Beira Interior (Portugal)

University of Cincinnati (USA)

Mendel University in Brno (Czech Republic)

Rio de Janeiro State University (Brazil)

Calcutta University (India)

University of Canterbury (New Zealand)

Macau University of Science and Technology (China)

National Hellenic Research Foundation (Greece)

University of Medicine and Pharmacy (Romania)

Sapienza University of Rome (Italy)

Warszawski Uniwersytet Medyczny (Poland)

Sri Ramachandra University (India)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

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Description:

Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity while stimulating range latent ATPase activity in the low concentration, so echinatin can disturb the mitochondrial energy transfer reactions and membrane permeability.

Targets:

ATPase | TNF-α | IL Receptor

In vitro:

J.Toxicol. Sci., 1982, 7(4):245-54.

The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction.[Pubmed: 6221118]

METHODS AND RESULTS:
To investigate the mechanism by which various biological action of licorice root are brought about, the effects of echinatin(Echinatine) as a small constituent of Glycyrrhiza echinata and several related compounds on mitochondrial energy transfer reactions were examined. The results obtained were as follows: 1) Echinatin, 4'-hydroxychalcone, chalcone and 3,4'-dihydroxychalcone at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria. 2) Chalcone and 4'-hydroxychalcone stimulate both latent and DNP-ATPase activity of mitochondria. Echinatin inhibits DNP-ATPase activity while stimulating range latent ATPase activity in the low concentration. 3) Chalcone and 4'-hydroxychalcone induce a rapid potassium release from mitochondrial vesicles, while echinatin and 3,4'-dihydroxychalcone have lesser effect than the former two substances.
CONCLUSIONS:
From these results, it can be concluded that echinatin and several related compounds disturb the mitochondrial energy transfer reactions and membrane permeability.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
蓝蓟定N-氧化物; Echimidine N-oxide	CFN00452	41093-89-4	C₂₀H₃₁NO₈ = 413.5	5mg	QQ客服：2056216494
刺凌德草碱; Echinatine	CFN00255	480-83-1	C₁₅H₂₅NO₅ = 299.37	5mg	QQ客服：3257982914
N-氧化刺凌德草碱; Echinatine N-oxide	CFN00256	20267-93-0	C₁₅H₂₅NO₆ = 315.36	5mg	QQ客服：1457312923
Cynoglossamine; Cynoglossamine	CFN00257	120193-39-7	C₂₄H₃₁NO₇ = 445.51	5mg	QQ客服：1413575084
凌德草碱; Rinderine	CFN00258	6029-84-1	C₁₅H₂₅NO₅ = 299.37	5mg	QQ客服：3257982914
凌德草碱N-氧化物; Rinderine N-oxide	CFN00470	137821-16-0	C₁₅H₂₅NO₆ = 315.4	5mg	QQ客服：2056216494
蓝蓟碱; Echiumine	CFN00259	633-16-9	C₂₀H₃₁NO₆ = 381.47	5mg	QQ客服：1413575084
Myoscorpine; Myoscorpine	CFN00260	82535-76-0	C₂₀H₃₁NO₆ = 381.47	5mg	QQ客服：1413575084
西门兰定; Symlandine	CFN00261	74410-74-5	C₂₀H₃₁NO₆ = 381.47	5mg	QQ客服：2056216494
Curassavine; Curassavine	CFN00251	68385-70-6	C₁₆H₂₉NO₄ = 299.41	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3403 mL	16.7017 mL	33.4035 mL	66.807 mL	83.5087 mL
5 mM	0.6681 mL	3.3403 mL	6.6807 mL	13.3614 mL	16.7017 mL
10 mM	0.334 mL	1.6702 mL	3.3403 mL	6.6807 mL	8.3509 mL
50 mM	0.0668 mL	0.334 mL	0.6681 mL	1.3361 mL	1.6702 mL
100 mM	0.0334 mL	0.167 mL	0.334 mL	0.6681 mL	0.8351 mL