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    • 刺凌德草碱

    Echinatine

    刺凌德草碱
    		产品编号 CFN00255
    CAS编号 480-83-1
    分子式 = 分子量 C15H25NO5 = 299.37
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Alkaloids
    植物来源 The herbs of Eupatorium cannabinum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    刺凌德草碱 CFN00255 480-83-1 1mg QQ客服：2159513211
    刺凌德草碱 CFN00255 480-83-1 5mg QQ客服：2159513211
    刺凌德草碱 CFN00255 480-83-1 10mg QQ客服：2159513211
    刺凌德草碱 CFN00255 480-83-1 20mg QQ客服：2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antimicrob Agents Chemother.2020, AAC.01921-20.
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  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Nutrients.2023, 15(3):753.
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  • Antioxidants (Basel).2022, 11(12):2411.
  • Anal Biochem.2019, 569:10-15
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  • Food Chem X.2024, 21:101127.
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • Int J Mol Sci.2021, 22(16):8641.
  • Front Pharmacol.2017, 8:205
  • Sichuan Agricultural University2023, 4630743.
  • ...
    • 生物活性
    Description: Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity while stimulating range latent ATPase activity in the low concentration, so echinatin can disturb the mitochondrial energy transfer reactions and membrane permeability.
    Targets: ATPase | TNF-α | IL Receptor
    In vitro:
    J.Toxicol. Sci., 1982, 7(4):245-54.
    The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction.[Pubmed: 6221118]

    METHODS AND RESULTS:
    To investigate the mechanism by which various biological action of licorice root are brought about, the effects of echinatin(Echinatine) as a small constituent of Glycyrrhiza echinata and several related compounds on mitochondrial energy transfer reactions were examined. The results obtained were as follows: 1) Echinatin, 4'-hydroxychalcone, chalcone and 3,4'-dihydroxychalcone at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria. 2) Chalcone and 4'-hydroxychalcone stimulate both latent and DNP-ATPase activity of mitochondria. Echinatin inhibits DNP-ATPase activity while stimulating range latent ATPase activity in the low concentration. 3) Chalcone and 4'-hydroxychalcone induce a rapid potassium release from mitochondrial vesicles, while echinatin and 3,4'-dihydroxychalcone have lesser effect than the former two substances.
    CONCLUSIONS:
    From these results, it can be concluded that echinatin and several related compounds disturb the mitochondrial energy transfer reactions and membrane permeability.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3403 mL 16.7017 mL 33.4035 mL 66.807 mL 83.5087 mL
    5 mM 0.6681 mL 3.3403 mL 6.6807 mL 13.3614 mL 16.7017 mL
    10 mM 0.334 mL 1.6702 mL 3.3403 mL 6.6807 mL 8.3509 mL
    50 mM 0.0668 mL 0.334 mL 0.6681 mL 1.3361 mL 1.6702 mL
    100 mM 0.0334 mL 0.167 mL 0.334 mL 0.6681 mL 0.8351 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蓝蓟碱; Echiumine CFN00259 633-16-9 C20H31NO6 = 381.47 5mg QQ客服：3257982914
    Myoscorpine; Myoscorpine CFN00260 82535-76-0 C20H31NO6 = 381.47 5mg QQ客服：2159513211
    西门兰定; Symlandine CFN00261 74410-74-5 C20H31NO6 = 381.47 5mg QQ客服：1457312923
    Curassavine; Curassavine CFN00251 68385-70-6 C16H29NO4 = 299.41 5mg QQ客服：2159513211
    蓝蓟定; Echimidine CFN00254 520-68-3 C20H31NO7 = 397.47 5mg QQ客服：2159513211
    蓝蓟定N-氧化物; Echimidine N-oxide CFN00452 41093-89-4 C20H31NO8 = 413.5 5mg QQ客服：1413575084
    刺凌德草碱; Echinatine CFN00255 480-83-1 C15H25NO5 = 299.37 5mg QQ客服：1413575084
    N-氧化刺凌德草碱; Echinatine N-oxide CFN00256 20267-93-0 C15H25NO6 = 315.36 5mg QQ客服：1413575084
    Cynoglossamine; Cynoglossamine CFN00257 120193-39-7 C24H31NO7 = 445.51 5mg QQ客服：2159513211
    凌德草碱; Rinderine CFN00258 6029-84-1 C15H25NO5 = 299.37 5mg QQ客服：2056216494

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