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  • 中药标准品生产商,产品定制服务
  • 黄独素C

    Diosbulbin C

    黄独素C
    产品编号 CFN98015
    CAS编号 20086-07-1
    分子式 = 分子量 C19H22O7 = 362.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Dioscorea bulbifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄独素C CFN98015 20086-07-1 1mg QQ客服:1457312923
    黄独素C CFN98015 20086-07-1 5mg QQ客服:1457312923
    黄独素C CFN98015 20086-07-1 10mg QQ客服:1457312923
    黄独素C CFN98015 20086-07-1 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Cell Metab.2020, S1550-4131(20)30002-4
  • Plos One.2020, 10.1371
  • Eur J Pharm Sci.2016, 94:33-45
  • Molecules.2022, 27(7):2116.
  • Nutrients.2019, 11(6):E1380
  • Phytother Res.2019, 33(7):1784-1793
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • BMC Complement Altern Med.2019, 19(1):367
  • Evid Based Complement Alternat Med.2020, 2020:9416962.
  • Appl. Sci.2020, 10(23), 8729
  • Acta Physiologiae Plantarum2015, 37:1736
  • Biomed Pharmacother.2019, 111:262-269
  • Bull. Natl. Mus. Nat. Sci.2021, 47(2),109-114.
  • Molecules.2019, 24(23):E4303
  • J Sep Sci.2018, 41(9):1938-1946
  • J Ethnopharmacol.2020, 260:112988.
  • Mol Med Rep.2014, 9(5):1653-9
  • J Nat Prod.2015, 78(6):1339-4
  • Int Immunopharmacol.2019, 71:22-31
  • Appl. Sci.2020, 10(8),2804
  • Pharmacogn Mag.2015, 11(43):562-6
  • Analytical sci. & Tech2016, 186-193
  • ...
  • 生物活性
    Description: Diosbulbin C has hepatotoxicity.
    In vitro:
    Chemical Research in Toxicology, 2018,31(9):843-851.
    An integrated metabolomics and proteomics approach to identify metabolic abnormalities in rats with Dioscorea bulbifera rhizome-induced hepatotoxicity.[Reference: WebLink]
    It is vital to monitor the holistic toxicokinetics of toxic Chinese herbal medicines (CHMs) for safety. Although an integrated strategy based on the area under the curve (AUC) has been proposed to characterize the pharmacokinetic/toxicokinetic properties of CHMs, improvement is still needed.
    METHODS AND RESULTS:
    This study attempted to use 50% inhibitory concentration (IC50) as weighting coefficient to investigate holistic toxicokinetics of the major diosbulbins i.e. diosbulbin A (DA), diosbulbin B (DB), and diosbulbin C (DC) after oral administration of Dioscorea bulbifera rhizome (DBR) extract. Firstly, the cytotoxicities of the three diosbulbins on human hepatic L02 cells were evaluated and the IC50 values were calculated. Then, integrated toxicokinetics of multiple diosbulbins based on AUC and IC50 were determined. Finally, correlations between integrated plasma concentrations and hepatic injury biomarkers including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bile acid (TBA) were analyzed. As a result, integrated plasma concentrations were correlated well with TBA and the correlation between TBA and IC50-weighting integrated plasma concentrations was better than that of AUC-weighting integrated plasma concentrations.
    CONCLUSIONS:
    In conclusion, the newly developed IC50-weighting method is expected to generate more reasonable integrated toxicokinetic parameters, which will help to guide the safe usage of DBR in clinical settings.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7594 mL 13.7969 mL 27.5938 mL 55.1876 mL 68.9845 mL
    5 mM 0.5519 mL 2.7594 mL 5.5188 mL 11.0375 mL 13.7969 mL
    10 mM 0.2759 mL 1.3797 mL 2.7594 mL 5.5188 mL 6.8985 mL
    50 mM 0.0552 mL 0.2759 mL 0.5519 mL 1.1038 mL 1.3797 mL
    100 mM 0.0276 mL 0.138 mL 0.2759 mL 0.5519 mL 0.6898 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黄独素D; Diosbulbin D CFN97140 66756-57-8 C19H20O6 = 344.4 5mg QQ客服:2159513211
    8-表黄药子素E乙酸酯; 8-Epidiosbulbin E acetate CFN90907 91095-48-6 C21H24O7 = 388.40 5mg QQ客服:2159513211
    黄独素I; Diosbulbin I CFN99288 1187951-05-8 C29H30O8 = 506.6 5mg QQ客服:2159513211
    黄独素 L; Diosbulbin L CFN89003 1236285-87-2 C19H22O7 = 362.37 5mg QQ客服:215959384
    黄独素J; Diosbulbin J CFN99289 1187951-06-9 C19H22O8 = 378.4 5mg QQ客服:3257982914
    Borapetoside B; Borapetoside B CFN96298 104901-05-5 C27H36O12 = 552.6 5mg QQ客服:2056216494
    Dehydroborapetoside B; Dehydroborapetoside B CFN96306 1221178-16-0 C27H34O12 = 550.6 5mg QQ客服:2056216494
    Borapetoside F; Borapetoside F CFN96279 151200-50-9 C27H34O11 = 534.6 5mg QQ客服:2159513211
    Borapetoside E; Borapetoside E CFN96274 151200-49-6 C27H36O11 = 536.6 5mg QQ客服:215959384
    Borapetoside D; Borapetoside D CFN96317 151200-48-5 C33H46O16 = 698.7 5mg QQ客服:215959384

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