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  • 黄独素C

    Diosbulbin C

    黄独素C
    产品编号 CFN98015
    CAS编号 20086-07-1
    分子式 = 分子量 C19H22O7 = 362.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Dioscorea bulbifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄独素C CFN98015 20086-07-1 1mg QQ客服:1457312923
    黄独素C CFN98015 20086-07-1 5mg QQ客服:1457312923
    黄独素C CFN98015 20086-07-1 10mg QQ客服:1457312923
    黄独素C CFN98015 20086-07-1 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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  • Thorac Cancer.2023, 14(21):2007-2017.
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  • Curr Issues Mol Biol.2023, ;45(2):1601-1612.
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  • ...
  • 生物活性
    Description: Diosbulbin C has hepatotoxicity.
    In vitro:
    Chemical Research in Toxicology, 2018,31(9):843-851.
    An integrated metabolomics and proteomics approach to identify metabolic abnormalities in rats with Dioscorea bulbifera rhizome-induced hepatotoxicity.[Reference: WebLink]
    It is vital to monitor the holistic toxicokinetics of toxic Chinese herbal medicines (CHMs) for safety. Although an integrated strategy based on the area under the curve (AUC) has been proposed to characterize the pharmacokinetic/toxicokinetic properties of CHMs, improvement is still needed.
    METHODS AND RESULTS:
    This study attempted to use 50% inhibitory concentration (IC50) as weighting coefficient to investigate holistic toxicokinetics of the major diosbulbins i.e. diosbulbin A (DA), diosbulbin B (DB), and diosbulbin C (DC) after oral administration of Dioscorea bulbifera rhizome (DBR) extract. Firstly, the cytotoxicities of the three diosbulbins on human hepatic L02 cells were evaluated and the IC50 values were calculated. Then, integrated toxicokinetics of multiple diosbulbins based on AUC and IC50 were determined. Finally, correlations between integrated plasma concentrations and hepatic injury biomarkers including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bile acid (TBA) were analyzed. As a result, integrated plasma concentrations were correlated well with TBA and the correlation between TBA and IC50-weighting integrated plasma concentrations was better than that of AUC-weighting integrated plasma concentrations.
    CONCLUSIONS:
    In conclusion, the newly developed IC50-weighting method is expected to generate more reasonable integrated toxicokinetic parameters, which will help to guide the safe usage of DBR in clinical settings.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7594 mL 13.7969 mL 27.5938 mL 55.1876 mL 68.9845 mL
    5 mM 0.5519 mL 2.7594 mL 5.5188 mL 11.0375 mL 13.7969 mL
    10 mM 0.2759 mL 1.3797 mL 2.7594 mL 5.5188 mL 6.8985 mL
    50 mM 0.0552 mL 0.2759 mL 0.5519 mL 1.1038 mL 1.3797 mL
    100 mM 0.0276 mL 0.138 mL 0.2759 mL 0.5519 mL 0.6898 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Dehydroborapetoside B; Dehydroborapetoside B CFN96306 1221178-16-0 C27H34O12 = 550.6 5mg QQ客服:2056216494
    Borapetoside F; Borapetoside F CFN96279 151200-50-9 C27H34O11 = 534.6 5mg QQ客服:215959384
    Borapetoside E; Borapetoside E CFN96274 151200-49-6 C27H36O11 = 536.6 10mg QQ客服:215959384
    Borapetoside D; Borapetoside D CFN96317 151200-48-5 C33H46O16 = 698.7 5mg QQ客服:2159513211
    黄独素C; Diosbulbin C CFN98015 20086-07-1 C19H22O7 = 362.4 5mg QQ客服:2056216494
    黄独素B; 黄独乙素; 黄药子素B; Diosbulbin B CFN98014 20086-06-0 C19H20O6 = 344.4 20mg QQ客服:2159513211
    Methyl-Dodovisate A; Methyl-Dodovisate A CFN97837 1246937-33-6 C21H26O3 = 326.43 5mg QQ客服:2159513211
    Isosalvipuberulin; Isosalvipuberulin CFN99251 115321-32-9 C20H14O5 = 334.3 5mg QQ客服:1413575084
    Tilifodiolide; Tilifodiolide CFN99378 126724-95-6 C20H16O5 = 336.3 5mg QQ客服:1413575084
    Dodonolide; Dodonolide CFN97753 349534-73-2 C20H24O3 = 312.41 5mg QQ客服:215959384

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