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  • 黄独素B; 黄独乙素; 黄药子素B

    Diosbulbin B

    黄独素B; 黄独乙素; 黄药子素B
    产品编号 CFN98014
    CAS编号 20086-06-0
    分子式 = 分子量 C19H20O6 = 344.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Dioscorea bulbifera
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄独素B; 黄独乙素; 黄药子素B CFN98014 20086-06-0 10mg QQ客服:1413575084
    黄独素B; 黄独乙素; 黄药子素B CFN98014 20086-06-0 20mg QQ客服:1413575084
    黄独素B; 黄独乙素; 黄药子素B CFN98014 20086-06-0 50mg QQ客服:1413575084
    黄独素B; 黄独乙素; 黄药子素B CFN98014 20086-06-0 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Leipzig (Germany)
  • Celltrion Chemical Research Institute (Korea)
  • University of Indonesia (Indonesia)
  • Indian Institute of Science (India)
  • Donald Danforth Plant Science Center (USA)
  • Nanjing University of Chinese Medicine (China)
  • The Ohio State University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2021, 26(9):2526.
  • Saudi Pharm J2020, 10.1016
  • Cell Death Differ.2021, 1-8.
  • Eur J Pharmacol.2022, 917:174744.
  • Comput Biol Chem.2019, 83:107096
  • Sci Rep.2019, 9(1):6429
  • Univerzita Karlova2022, 173245.
  • Phytomedicine.2021, 2(82):153452
  • Am J Chin Med.2016, 44(6):1255-1271
  • Nutr Res Pract2019, 13:e45
  • Mie University2019, 10076.
  • Plant Foods Hum Nutr.2020, 10.1007
  • J Ethnopharmacol.2019, 236:31-41
  • LWT-Food Science and Technology2017, 75:488-496
  • Cancers (Basel).2021, 13(6):1432.
  • J Neuroinflammation.2020, 17(1):75.
  • Processes2020, 8(12),1540.
  • Chemistry of Plant Materials.2019, 215-222
  • Molecules.2019, 24(11):E2044
  • Academic J of Second Military Medical University2018, 39(11)
  • Oxid Med Cell Longev2020, 12
  • Vietnam J. Chemistry2022, 60(2):211-222
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • ...
  • 生物活性
    Description: Diosbulbin B has potential anti-tumor effects which may be related to influencing the immune system for the first time, it also exhibits potential hepatotoxicity.
    Targets: P450 (e.g. CYP17)
    In vivo:
    J Zhejiang Univ Sci B. 2014 Jun;15(6):540-7.
    Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo.[Pubmed: 24903991]

    METHODS AND RESULTS:
    The present study is designed to investigate the protection by ferulic acid against the hepatotoxicity induced by diosbulbin B and its possible mechanism, and further observe whether ferulic acid augments diosbulbin B-induced anti-tumor activity. The results show that ferulic acid decreases diosbulbin B-increased serum alanine transaminase/aspartate transaminase (ALT/AST) levels. Ferulic acid also decreases lipid peroxide (LPO) levels which are elevated in diosbulbin B-treated mice. Histological evaluation of the liver demonstrates hydropic degeneration in diosbulbin B-treated mice, while ferulic acid reverses this injury. Moreover, the activities of copper- and zinc-containing superoxide dismutase (CuZn-SOD) and catalase (CAT) are decreased in the livers of diosbulbin B-treated mice, while ferulic acid reverses these decreases. Further results demonstrate that the mRNA expressions of CuZn-SOD and CAT in diosbulbin B-treated mouse liver are significantly decreased, while ferulic acid prevents this decrease. In addition, ferulic acid also augments diosbulbin B-induced tumor growth inhibition compared with diosbulbin B alone.
    CONCLUSIONS:
    Taken together, the present study shows that ferulic acid prevents diosbulbin B-induced liver injury via ameliorating diosbulbin B-induced liver oxidative stress injury and augments diosbulbin B-induced anti-tumor activity.
    Hum Exp Toxicol. 2014 Jul;33(7):729-36.
    Diosbulbin B-induced liver injury in mice and its mechanism.[Pubmed: 24107456]
    Dioscorea bulbifera L., a commonly used medicinal plant in China, is reported to induce hepatotoxicity. The present study is undertaken to investigate the hepatotoxicity induced by Diosbulbin B (DB), a diterpene lactone isolated from D. bulbifera L., and to further explore its underlying mechanism.
    METHODS AND RESULTS:
    DB was administered to mice at the doses of 0, 16, 32, and 64 mg/kg once daily for 12 consecutive days. Liver injury induced by Diosbulbin B was evidenced by the increased activity of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Liver histological evaluation showed that the mice treated with Diosbulbin B exhibited liver damage with the swelling of hepatocytes. Further results showed that the amount of malondialdehyde (MDA) in the liver was increased in mice treated with Diosbulbin B, while the glutathione amount and the enzymatic activity of glutathione peroxidase (GPx), glutathione-S-transferase (GST), copper/zinc-superoxide dismutase (CuZn-SOD), manganese-SOD (Mn-SOD), and catalase (CAT) were all decreased. Diosbulbin B also decreased the gene expression of CuZn-SOD and CAT.
    CONCLUSIONS:
    Taken together, our results indicate that oral administration of Diosbulbin B for 12 consecutive days can lead to the oxidative stress liver injury in mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9036 mL 14.518 mL 29.036 mL 58.072 mL 72.59 mL
    5 mM 0.5807 mL 2.9036 mL 5.8072 mL 11.6144 mL 14.518 mL
    10 mM 0.2904 mL 1.4518 mL 2.9036 mL 5.8072 mL 7.259 mL
    50 mM 0.0581 mL 0.2904 mL 0.5807 mL 1.1614 mL 1.4518 mL
    100 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5807 mL 0.7259 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Dehydroborapetoside B; Dehydroborapetoside B CFN96306 1221178-16-0 C27H34O12 = 550.6 5mg QQ客服:2159513211
    Borapetoside F; Borapetoside F CFN96279 151200-50-9 C27H34O11 = 534.6 5mg QQ客服:1413575084
    Borapetoside E; Borapetoside E CFN96274 151200-49-6 C27H36O11 = 536.6 5mg QQ客服:2056216494
    Borapetoside D; Borapetoside D CFN96317 151200-48-5 C33H46O16 = 698.7 5mg QQ客服:2056216494
    黄独素C; Diosbulbin C CFN98015 20086-07-1 C19H22O7 = 362.4 5mg QQ客服:2056216494
    黄独素B; 黄独乙素; 黄药子素B; Diosbulbin B CFN98014 20086-06-0 C19H20O6 = 344.4 20mg QQ客服:1413575084
    Methyl-Dodovisate A; Methyl-Dodovisate A CFN97837 1246937-33-6 C21H26O3 = 326.43 5mg QQ客服:1457312923
    Isosalvipuberulin; Isosalvipuberulin CFN99251 115321-32-9 C20H14O5 = 334.3 5mg QQ客服:2056216494
    Tilifodiolide; Tilifodiolide CFN99378 126724-95-6 C20H16O5 = 336.3 5mg QQ客服:215959384
    Dodonolide; Dodonolide CFN97753 349534-73-2 C20H24O3 = 312.41 5mg QQ客服:215959384

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