二氢白屈菜红碱

Dihydrochelerythrine

	产品编号	CFN90127
	CAS编号	6880-91-7
	分子式 = 分子量	C₂₁H₁₉NO₄ = 349.38
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Chelidonium majus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
二氢白屈菜红碱	CFN90127	6880-91-7	10mg	QQ客服：215959384
二氢白屈菜红碱	CFN90127	6880-91-7	20mg	QQ客服：215959384
二氢白屈菜红碱	CFN90127	6880-91-7	50mg	QQ客服：215959384
二氢白屈菜红碱	CFN90127	6880-91-7	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Macau University of Science and Technology (China)

Worcester Polytechnic Institute (USA)

University Medical Center Mainz (Germany)

Utrecht University (Netherlands)

Uniwersytet Medyczny w ?odzi (Poland)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

Texas A&M University (USA)

University of Maryland School of Medicine (USA)

University of Padjajaran (Indonesia)

Univerzita Karlova v Praze (Czech Republic)

Sanford Burnham Prebys Medical Discovery Institute (USA)

University of Hertfordshire (United Kingdom)

Georgia Institute of Technology (USA)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

More...

Description:

Dihydrochelerythrine has antifungal activity against pathogenic plant fungi; it shows antiparasitic efficacy against Ichthyophthirius multifiliis in richadsin, it has potential application in the therapy of serious infection caused by I. multifiliis. Dihydrochelerythrine affects cell cycle distribution, activates mitochondrial apoptotic pathway, and induces apoptosis and necrosis in HL-60 cells.

Targets:

Antifection | Caspase

In vitro:

Nat Prod Res. 2011 Jul;25(11):1082-9.

Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi.[Pubmed: 21500094]

The antifungal activities of dihydrosanguinarine and dihydrochelerythrine, isolated from the leaves of Macleaya microcarpa, were evaluated on 12 plant pathogenic fungi; the two compounds exhibited the highest antifungal activity against Botrytis cinerea Pers.
METHODS AND RESULTS:
Among the 11 tested plant pathogenic fungi in vitro, the two compounds showed the highest antifungal activity against B. cinerea Pers, with 95.16% and 98.32% mycelial growth inhibition at 50 μg mL⁻1, respectively. In addition, the two compounds inhibited spore germination in vitro in a concentration-dependent manner. They also showed potent protective and curative effects against Erysiphe graminis and B. cinerea in vivo.
CONCLUSIONS:
This is the first report on the antifungal activity of dihydrosanguinarine and dihydrochelerythrine against pathogenic plant fungi.

In vivo:

Vet Parasitol. 2011 Dec 29;183(1-2):8-13.

Antiparasitic efficacy of dihydrosanguinarine and dihydrochelerythrine from Macleaya microcarpa against Ichthyophthirius multifiliis in richadsin (Squaliobarbus curriculus).[Pubmed: 21813242]

Ichthyophthirius multifiliis is a holotrichous protozoan that invades the gills and skin surfaces of fish and can cause morbidity and high mortality in most species of freshwater fish worldwide. The present study was undertaken to investigate the antiparasitic activity of crude extracts and pure compounds from the leaves of Macleaya microcarpa.
METHODS AND RESULTS:
The chloroform extract showed a promising antiparasitic activity against I. multifiliis. Based on these finding, the chloroform extract was fractionated on silica gel column chromatography in a bioactivity-guided isolation affording two compounds showing potent activity. The structures of the two compounds were elucidated as dihydrosanguinarine and dihydrochelerythrine by hydrogen and carbon-13 nuclear magnetic resonance spectrum and electron ionization mass spectrometry. The in vivo tests revealed that dihydrosanguinarine and dihydrochelerythrine were effective against I. multifiliis with median effective concentration (EC(50)) values of 5.18 and 9.43 mg/l, respectively. The acute toxicities (LC(50)) of dihydrosanguinarine and dihydrochelerythrine for richadsin were 13.3 and 18.2mg/l, respectively.
CONCLUSIONS:
The overall results provided important information for the potential application of dihydrosanguinarine and dihydrochelerythrine in the therapy of serious infection caused by I. multifiliis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
8-乙酰甲基二氢两面针碱; 8-Acetonyldihydronitidine	CFN92339	80330-39-8	C₂₄H₂₃NO₅ = 405.5	5mg	QQ客服：1413575084
bis[6-(5,6-dihydrochelerythrinyl)]amine; bis[6-(5,6-dihydrochelerythrinyl)]amine	CFN91015	165393-48-6	C₄₂H₃₇N₃O₈ = 711.76	5mg	QQ客服：2159513211
乙酰紫堇灵; Acetylcorynoline	CFN99749	18797-80-3	C₂₃H₂₃NO₆ = 409.43	20mg	QQ客服：2056216494
白屈菜碱; Chelidonine	CFN90319	476-32-4	C₂₀H₁₉NO₅ = 353.37	20mg	QQ客服：2159513211
二氢白屈菜红碱; Dihydrochelerythrine	CFN90127	6880-91-7	C₂₁H₁₉NO₄ = 349.38	20mg	QQ客服：2056216494
去甲白屈菜红碱; Norchelerythrine	CFN92737	6900-99-8	C₂₀H₁₅NO₄ = 333.3	5mg	QQ客服：215959384
氧基白屈菜季铵碱; Oxychelerythrine	CFN97999	28342-33-8	C₂₁H₁₇NO₅ = 363.4	5mg	QQ客服：2159513211
德卡林碱; Decarine	CFN98909	54354-62-0	C₁₉H₁₃NO₄ = 319.3	5mg	QQ客服：1413575084
氯化两面针碱; Nitidine chloride	CFN98109	13063-04-2	C₂₁H₁₈ClNO₄ = 383.83	20mg	QQ客服：1413575084
血根碱; Sanguinarine	CFN98259	2447-54-3	C₂₀H₁₄NO₄ = 332.3	20mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8622 mL	14.3111 mL	28.6221 mL	57.2443 mL	71.5553 mL
5 mM	0.5724 mL	2.8622 mL	5.7244 mL	11.4489 mL	14.3111 mL
10 mM	0.2862 mL	1.4311 mL	2.8622 mL	5.7244 mL	7.1555 mL
50 mM	0.0572 mL	0.2862 mL	0.5724 mL	1.1449 mL	1.4311 mL
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	0.5724 mL	0.7156 mL

二氢白屈菜红碱

Dihydrochelerythrine

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