| Description: |
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is a potent inducer of apoptosis in HCT116 and SW620 cell lines, it displays potent cytotoxic activity in human HCT116 and SW620 colon carcinoma cells, to a higher extent than 5-fluorouracil (5-FU), the cornerstone chemotherapeutic agent in colon cancer. |
| In vitro: |
| Planta Med. 2003 Feb;69(2):148-52. | | Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana.[Pubmed: 12624820] |
METHODS AND RESULTS:
Antioxidative activity-guided fractionation together with chemical analysis led to the isolation of three benzophenanthridine alkaloids from methanol extract of the bark of Bocconia arborea. Identification was based on spectroscopic methods. The isolated alkaloids 6-acetonyldihydrochelerythrine, chelerythrine and dihydrochelerythrine were tested for antioxidative activity on thiocyanate assays, free radical scavenging activity, β β β β β-carotene bleaching method, and deoxyribose assay.
CONCLUSIONS:
All alkaloids exhibited significant antioxidant activities in linoleic acid and β β β β β-carotene. Although afforded protection against the damage of deoxyribose, liposome peroxidation and microsomial lipid from peroxidation, also exhibited scavenging effects on the 1,1-diphenyl-2-picrylhydrazyl radicals. | | Ars Pharmaceutica,2003,44(1):5-21. | | Actividad antioxidante de los alcaloides de Bocconia arborea. Estudio sobre seis métodos de análisis Antioxidant activity of alkaloids from Bocconia arborea. A study on six testing methods[Reference: WebLink] |
METHODS AND RESULTS:
Antioxidative activity-guided fractionation together with chemical analysis led to the isolation of three benzophenanthridine alkaloids from methanol extract of the bark of Bocconia arborea. Identification was based on spectroscopic methods. The isolated alkaloids 6-Acetonyldihydrochelerythrine, chelerythrine and dihydrochelerythrine were tested for antioxidative activity on thiocyanate assays, free radical scavenging activity, β β β β β-carotene bleaching method, and deoxyribose assay.
CONCLUSIONS:
All alkaloids exhibited significant antioxidant activities in linoleic acid and β β β β β-carotene. Although afforded protection against the damage of deoxyribose, liposome peroxidation and microsomial lipid from peroxidation, also exhibited scavenging effects on the 1,1-diphenyl-2-picrylhydrazyl radicals. |
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