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  • Diacetylpiptocarphol

    Diacetylpiptocarphol

    Diacetylpiptocarphol
    产品编号 CFN97859
    CAS编号 103476-99-9
    分子式 = 分子量 C19H24O9 = 396.39
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Vernonia volkameriifolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Diacetylpiptocarphol CFN97859 103476-99-9 1mg QQ客服:2159513211
    Diacetylpiptocarphol CFN97859 103476-99-9 5mg QQ客服:2159513211
    Diacetylpiptocarphol CFN97859 103476-99-9 10mg QQ客服:2159513211
    Diacetylpiptocarphol CFN97859 103476-99-9 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Copenhagen University (Denmark)
  • University of Minnesota (USA)
  • University of Wisconsin-Madison (USA)
  • University of Virginia (USA)
  • University of Eastern Finland (Finland)
  • University of Sao Paulo (Brazil)
  • FORTH-IMBB (Greece)
  • Medizinische Universit?t Wien (Austria)
  • Lodz University of Technology (Poland)
  • University of Madras (India)
  • University of Beira Interior (Portugal)
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  • Utah State University (USA)
  • Monash University Malaysia (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2021, 26(6):1738.
  • J Drug Target.2016, 24:1-28
  • Cancer Sci.2022, 113(4):1406-1416.
  • Pharmaceutics.2020, 12(9):845.
  • Front Immunol.2018, 9:2655
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • Oxid Med Cell Longev.2022, 2022:9139338.
  • Dent Mater J.2020, 39(4):690-695
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Univerzita Karlova2021, 20.500.11956.
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Mol Cells.2018, 41(8):771-780
  • Fermentation2023, 9(10), 889
  • Ind Crops Prod.2015, 67:185-191
  • Antioxidants (Basel).2021, 10(11):1831.
  • Sci Rep.2017, 7:46299
  • J. Korean Wood Sci. Technol.2022, 50(5):338-352.
  • Applied Biological Chemistry2022, 71:s13765-022-00743-5.
  • Turk J Med Sci.2023 53: 1312-1320.
  • Foods2023, 12(23), 4342.
  • Vietnam J. Chemistry2022, 60(2):211-222
  • Foods.2020, 9(10):1348.
  • ...
  • 生物活性
    Description: Diacetylpiptocarphol shows antileishmanial activity against three stages of Leishmania infantum.
    Targets: Antifection
    In vitro:
    J Ethnopharmacol. 2015 Jul 21;170:167-74.
    Evaluation of antiplasmodial and antileishmanial activities of herbal medicine Pseudelephantopus spiralis (Less.) Cronquist and isolated hirsutinolide-type sesquiterpenoids.[Pubmed: 25980423]

    METHODS AND RESULTS:
    Aerial parts of P. spiralis were extracted with either ethanol or distilled water. Seven hirsutinolide-type sesquiterpenoids were isolated: 8-acetyl-13-ethoxypiptocarphol (1), Diacetylpiptocarphol (2), piptocarphins A (3), F (4) and D (5), (1S(*),4R(*),8S(*),10R(*))-1,4-epoxy-13-ethoxy-1,8,10-trihydroxygermacra-5E,7(11)-dien-6,12-olide (6), and piptocarphol (7). Extracts and isolated compounds (2, 3, 5-7) were screened for their in vitro antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum strain FcM29-Cameroon and antileishmanial activity against three stages of Leishmania infantum. Their cytotoxicities were also evaluated against healthy VERO cell lines and J774A.1 macrophages, the host cells of the Leishmania parasites in humans.
    CONCLUSIONS:
    Aqueous extract and compounds Diacetylpiptocarphol, 3 and 6 were also active against L. infantum but lacked in selectivity due to their cytotoxicity towards macrophages.
    Phytochemistry. 2010 Sep;71(13):1539-44.
    Sesquiterpene lactones from Vernonia scorpioides and their in vitro cytotoxicity.[Pubmed: 20599237]
    Fresh leaves of Vernonia scorpioides are widely used in Brazil to treat a variety of skin disorders. Previous in vivo studies with extracts of this species had also demonstrated a high antitumor potential.
    METHODS AND RESULTS:
    This paper reports isolation of four sesquiterpene lactones (hirsutinolides and glaucolides), together with diacetylpiptocarphol, 8-acetyl-13-etoxypiptocarphol, luteolin, apigenin, and ethyl caffeate from fresh leaves and flowers of Vernonia scorpioides. The hypothesis that hirsutinolide 3 is formed during extraction was verified theoretically using Density Functional Theory. The effects of isolated compounds on in vitro tumor cells were investigated, as well as their genotoxicity by means of an in vitro comet assay.
    CONCLUSIONS:
    The results indicate that glaucolide 2 and hirsutinolide 4 are toxic to HeLa cells. These compounds were genotoxic in vitro, a property that appears to be related to the presence of their epoxy groups, which has been a more reliable indication of toxicity than substitution on C-13 or the presence of alpha,beta-unsaturated keto-groups. These results need to be replicated in vivo in order to ascertain their toxicity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5228 mL 12.6138 mL 25.2277 mL 50.4554 mL 63.0692 mL
    5 mM 0.5046 mL 2.5228 mL 5.0455 mL 10.0911 mL 12.6138 mL
    10 mM 0.2523 mL 1.2614 mL 2.5228 mL 5.0455 mL 6.3069 mL
    50 mM 0.0505 mL 0.2523 mL 0.5046 mL 1.0091 mL 1.2614 mL
    100 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.5046 mL 0.6307 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    圆叶肿柄菊素D; Tirotundin CFN98943 56377-67-4 C19H28O6 = 352.4 5mg QQ客服:1457312923
    3-O-甲基圆叶肿柄菊素D; 3-O-Methyltirotundin CFN99038 1021945-29-8 C20H30O6 = 366.5 5mg QQ客服:215959384
    圆叶肿柄菊素A; Tagitinin A CFN97012 59979-61-2 C19H28O7 = 368.4 5mg QQ客服:215959384
    1-乙酰基圆叶肿柄菊素A; 1-Acetyltagitinin A CFN97030 60547-63-9 C21H30O8 = 410.5 5mg QQ客服:3257982914
    8alpha-羟基硬毛钩藤内酯 ; 8alpha-Hydroxyhirsutinolide CFN96809 1394156-45-6 C15H20O6 = 296.31 5mg QQ客服:1413575084
    8alpha-(2-甲基丙烯酰氧基)硬毛钩藤内酯 ; 8alpha-(2-Methylacryloyloxy)hirsutinolide CFN96807 188293-70-1 C19H24O7 = 364.39 5mg QQ客服:2159513211
    8alpha-(2-甲基丙烯酰氧基)硬毛钩藤内酯 13-O-乙酸酯; 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate CFN96805 67667-71-4 C21H26O8 = 406.43 5mg QQ客服:1457312923
    8alpha-(2-甲基丙烯酰氧基)-1alpha-甲氧基硬毛钩藤内酯-13-O-乙酸酯; 8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate CFN96804 883872-71-7 C22H28O8 = 420.45 5mg QQ客服:1413575084
    8alpha-巴豆酰氧基硬毛钩藤内酯 13-O-乙酸酯 ; 8alpha-Tigloyloxyhirsutinolide 13-O-acetate CFN96806 83182-58-5 C22H28O8 = 420.45 5mg QQ客服:2056216494
    Diacetylpiptocarphol; Diacetylpiptocarphol CFN97859 103476-99-9 C19H24O9 = 396.39 5mg QQ客服:2056216494

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