圆叶肿柄菊素D

Tirotundin

	产品编号	CFN98943
	CAS编号	56377-67-4
	分子式 = 分子量	C₁₉H₂₈O₆ = 352.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The leave of Tithonia diversifolia
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
圆叶肿柄菊素D	CFN98943	56377-67-4	1mg	QQ客服：3257982914
圆叶肿柄菊素D	CFN98943	56377-67-4	5mg	QQ客服：3257982914
圆叶肿柄菊素D	CFN98943	56377-67-4	10mg	QQ客服：3257982914
圆叶肿柄菊素D	CFN98943	56377-67-4	20mg	QQ客服：3257982914

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Minnesota (USA)

University of Melbourne (Australia)

University of Zurich (Switzerland)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

University of Liège (Belgium)

University of Padjajaran (Indonesia)

National Cancer Institute (USA)

University of Mysore (India)

Sapienza University of Rome (Italy)

University of Toulouse (France)

Biotech R&D Institute (USA)

Universidade Federal de Pernambuco (UFPE) (Brazil)

Colorado State University (USA)

Deutsches Krebsforschungszentrum (Germany)

More...

Description:

Tirotundin is a PPARα/γ dual agonist, it exerts anti-diabetic effect through PPARγ pathway. It shows anti-inflammatory activity, it inhibits inhibit the activation of NF-kappa B, thereby, the synthesis of inflammatory mediators such as cytokines and chemokines is reduced.

Targets:

PPAR | NF-kB | COX

In vitro:

Planta Med. 1998 Oct;64(7):588-93.

Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-kappa B and enzymes of the arachidonic acid pathway as targets.[Pubmed: 9810261]

In Central America leaf extracts from the Asteraceae Tithonia diversifolia are used externally for the treatment of haematomas and wounds. Therefore, the main sesquiterpene lactones (Sls) of this species growing in Costa Rica, diversifolin (1), diversifolin methyl ether (2), and Tirotundin (3), were studied for their anti-inflammatory activity.
METHODS AND RESULTS:
We determined whether these compounds inhibit cyclooxygenase-I, phospholipase A2, or the transcription factor NF-kappa B. Here we show that these Sls do not influence the enzymes of the arachidonic acid pathway, but inhibit the activation of NF-kappa B. Thereby, the synthesis of inflammatory mediators such as cytokines and chemokines is reduced.
CONCLUSIONS:
Our results indicate that the inhibitory activity of compounds 1-3 is due to alkylation of cysteine residues, which are probably located in the DNA binding domain of NF-kappa B. The Sls were also studied for their antibacterial activity, but only Sl 1 was moderately active against Bacillus subtilis in the agar plate diffusion test.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
圆叶肿柄菊素A; Tagitinin A	CFN97012	59979-61-2	C₁₉H₂₈O₇ = 368.4	5mg	QQ客服：2159513211
1-乙酰基圆叶肿柄菊素A; 1-Acetyltagitinin A	CFN97030	60547-63-9	C₂₁H₃₀O₈ = 410.5	5mg	QQ客服：1413575084
8alpha-羟基硬毛钩藤内酯 ; 8alpha-Hydroxyhirsutinolide	CFN96809	1394156-45-6	C₁₅H₂₀O₆ = 296.31	5mg	QQ客服：3257982914
8alpha-(2-甲基丙烯酰氧基)硬毛钩藤内酯 ; 8alpha-(2-Methylacryloyloxy)hirsutinolide	CFN96807	188293-70-1	C₁₉H₂₄O₇ = 364.39	5mg	QQ客服：1413575084
8alpha-(2-甲基丙烯酰氧基)硬毛钩藤内酯 13-O-乙酸酯; 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate	CFN96805	67667-71-4	C₂₁H₂₆O₈ = 406.43	5mg	QQ客服：1457312923
8alpha-(2-甲基丙烯酰氧基)-1alpha-甲氧基硬毛钩藤内酯-13-O-乙酸酯; 8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate	CFN96804	883872-71-7	C₂₂H₂₈O₈ = 420.45	5mg	QQ客服：2159513211
8alpha-巴豆酰氧基硬毛钩藤内酯 13-O-乙酸酯 ; 8alpha-Tigloyloxyhirsutinolide 13-O-acetate	CFN96806	83182-58-5	C₂₂H₂₈O₈ = 420.45	5mg	QQ客服：2159513211
Diacetylpiptocarphol; Diacetylpiptocarphol	CFN97859	103476-99-9	C₁₉H₂₄O₉ = 396.39	5mg	QQ客服：215959384
Piptocarphin A; Piptocarphin A	CFN97688	76248-63-0	C₂₁H₂₆O₉ = 422.43	5mg	QQ客服：1413575084
4'-Hydroxypiptocarphin A; 4'-Hydroxypiptocarphin A	CFN96811	103994-39-4	C₂₁H₂₆O₁₀ = 438.42	5mg	QQ客服：2056216494

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8377 mL	14.1884 mL	28.3768 mL	56.7537 mL	70.9421 mL
5 mM	0.5675 mL	2.8377 mL	5.6754 mL	11.3507 mL	14.1884 mL
10 mM	0.2838 mL	1.4188 mL	2.8377 mL	5.6754 mL	7.0942 mL
50 mM	0.0568 mL	0.2838 mL	0.5675 mL	1.1351 mL	1.4188 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	0.5675 mL	0.7094 mL