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  • 圆叶肿柄菊素A

    Tagitinin A

    圆叶肿柄菊素A
    产品编号 CFN97012
    CAS编号 59979-61-2
    分子式 = 分子量 C19H28O7 = 368.4
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Tithonia diversifolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    圆叶肿柄菊素A CFN97012 59979-61-2 1mg QQ客服:1413575084
    圆叶肿柄菊素A CFN97012 59979-61-2 5mg QQ客服:1413575084
    圆叶肿柄菊素A CFN97012 59979-61-2 10mg QQ客服:1413575084
    圆叶肿柄菊素A CFN97012 59979-61-2 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Vienna (Austria)
  • Imperial College London (United Kingdom)
  • Griffith University (Australia)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Nanjing University of Chinese Medicine (China)
  • Monash University Malaysia (Malaysia)
  • University of Lodz (Poland)
  • Universidade de Franca (Brazil)
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  • University of Auckland (New Zealand)
  • Max Rubner-Institut (MRI) (Germany)
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  • Universidade Católica Portuguesa (Portugal)
  • The Australian National University (Australia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Res Int.2017, 96:40-45
  • J Health Sci Med Res.2023, 31584.
  • Food Chem. 2020, 320:126530
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Foods.2021, 10(11):2754.
  • Antibiotics.2022, 11(4), 510.
  • Research Square2021, 10.21203.
  • J Cell Mol Med . 2023, jcmm.17954.
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Chin Med.2022, 17(1):66.
  • Molecules.2021, 26(2):313.
  • Chemistry of Plant Materials.2016, 33-46
  • Res Rep Urol.2022, 14:313-326.
  • Microorganisms.2021, 9(12):2514.
  • Separation Science Plus2022, sscp.202200048.
  • Int J Cosmet Sci.2019, 41(1):12-20
  • J Ethnopharmacol.2020, 260:112988.
  • Biomed Pharmacother.2022, 145:112474.
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • J Funct Foods2019, 54:449-456
  • J Sep Sci.2020, 43(22):4148-4161.
  • Natural Product Communications2020, doi: 10.1177.
  • J Biosci.2020, 45:46.
  • ...
  • 生物活性
    Description: Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the growth of STS and weeds. Tagitinin A is also a PPARα/γ dual agonist , it exerts anti-diabetic effect through PPARγ pathway.
    Targets: PPAR | Antifection
    In vitro:
    PLoS One. 2015 Nov 23;10(11):e0143530.
    Extracts from Field Margin Weeds Provide Economically Viable and Environmentally Benign Pest Control Compared to Synthetic Pesticides.[Pubmed: 26599609 ]
    Plants with pesticidal properties have been investigated for decades as alternatives to synthetics, but most progress has been shown in the laboratory. Consequently, research on pesticidal plants is failing to address gaps in our knowledge that constrain their uptake. Some of these gaps are their evaluation of their efficacy under field conditions, their economic viability and impact on beneficial organisms.
    METHODS AND RESULTS:
    Extracts made from four abundant weed species found in northern Tanzania, Tithonia diversifolia, Tephrosia vogelii, Vernonia amygdalina and Lippia javanica offered effective control of key pest species on common bean plants (Phaseolus vulgaris) that was comparable to the pyrethroid synthetic, Karate. The plant pesticide treatments had significantly lower effects on natural enemies (lady beetles and spiders). Plant pesticide treatments were more cost effective to use than the synthetic pesticide where the marginal rate of return for the synthetic was no different from the untreated control, around 4USD/ha, compared to a rate of return of around 5.50USD/ha for plant pesticide treatments. Chemical analysis confirmed the presence of known insecticidal compounds in water extracts of T. vogelii (the rotenoid deguelin) and T. diversifolia (the sesquiterpene lactone Tagitinin A). Sesquiterpene lactones and the saponin vernonioside C were also identified in organic extracts of V. amygdalina but only the saponin was recorded in water extracts which are similar to those used in the field trial.
    CONCLUSIONS:
    Pesticidal plants were better able to facilitate ecosystem services whilst effectively managing pests. The labour costs of collecting and processing abundant plants near farm land were less than the cost of purchasing synthetic pesticides.
    J Nat Prod. 2015 May 22;78(5):1083-92.
    Phytotoxins from Tithonia diversifolia.[Pubmed: 25879678 ]
    Tithonia diversifolia (Mexican sunflower) is a dominant plant of the Asteraceae family, which suggests it produces allelochemicals that interfere with the development of surrounding plants. The study described herein was conducted to identify the compounds that have phytotoxic activity in T. diversifolia extracts.
    METHODS AND RESULTS:
    Ethyl acetate extracts of the leaves, stems, and roots showed significant inhibition of wheat coleoptile growth, and the leaf extract had similar inhibitory effects to a commercial herbicide. Fourteen compounds, 12 of which were sesquiterpene lactones, have been isolated. Two sesquiterpene lactones are reported for the first time and were isolated as an inseparable mixture of 8β-O-(2-methylbutyroyl)tirotundin (4) and 8β-O-(isovaleroyl)tirotundin (5). Their structures were determined by spectroscopic analysis, including NMR techniques and mass spectrometry. The sesquiterpene lactones 1β-methoxydiversifolin (6), Tagitinin A (7), and tagitinin C (8) were the major products identified.
    CONCLUSIONS:
    These compounds were active on etiolated wheat coleoptiles, seed germination, and the growth of STS and weeds. The phytotoxic activity shown by these sesquiterpene lactones indicates that they are the compounds responsible for the activity exhibited by the initial extracts.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7144 mL 13.5722 mL 27.1444 mL 54.2888 mL 67.861 mL
    5 mM 0.5429 mL 2.7144 mL 5.4289 mL 10.8578 mL 13.5722 mL
    10 mM 0.2714 mL 1.3572 mL 2.7144 mL 5.4289 mL 6.7861 mL
    50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0858 mL 1.3572 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-O-甲基圆叶肿柄菊素F; 3-O-Methyltagitinin F CFN99204 110382-37-1 C20H26O6 = 362.4 5mg QQ客服:2056216494
    圆叶肿柄菊素D; Tirotundin CFN98943 56377-67-4 C19H28O6 = 352.4 5mg QQ客服:215959384
    3-O-甲基圆叶肿柄菊素D; 3-O-Methyltirotundin CFN99038 1021945-29-8 C20H30O6 = 366.5 5mg QQ客服:1413575084
    圆叶肿柄菊素A; Tagitinin A CFN97012 59979-61-2 C19H28O7 = 368.4 5mg QQ客服:1457312923
    1-乙酰基圆叶肿柄菊素A; 1-Acetyltagitinin A CFN97030 60547-63-9 C21H30O8 = 410.5 5mg QQ客服:1413575084
    8alpha-羟基硬毛钩藤内酯 ; 8alpha-Hydroxyhirsutinolide CFN96809 1394156-45-6 C15H20O6 = 296.31 5mg QQ客服:2056216494
    8alpha-(2-甲基丙烯酰氧基)硬毛钩藤内酯 ; 8alpha-(2-Methylacryloyloxy)hirsutinolide CFN96807 188293-70-1 C19H24O7 = 364.39 5mg QQ客服:1457312923
    8alpha-(2-甲基丙烯酰氧基)硬毛钩藤内酯 13-O-乙酸酯; 8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate CFN96805 67667-71-4 C21H26O8 = 406.43 5mg QQ客服:2056216494
    8alpha-(2-甲基丙烯酰氧基)-1alpha-甲氧基硬毛钩藤内酯-13-O-乙酸酯; 8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate CFN96804 883872-71-7 C22H28O8 = 420.45 5mg QQ客服:2159513211
    8alpha-巴豆酰氧基硬毛钩藤内酯 13-O-乙酸酯 ; 8alpha-Tigloyloxyhirsutinolide 13-O-acetate CFN96806 83182-58-5 C22H28O8 = 420.45 5mg QQ客服:2056216494

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