| Description: |
Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tube formation, migration, and adhesion on human umbilical vein endothelial cells.It is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. Delta-tocotrienol displays significant radioprotective effects, it protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. |
| In vivo: |
| Haematologica. 2010 Dec;95(12):1996-2004. | | Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling.[Pubmed: 20823133 ] | Delta-Tocotrienol displayed significant radioprotective effects.
METHODS AND RESULTS:
A single injection of Delta-Tocotrienol protected 100% of CD2F1 mice from total body irradiation-induced death as measured by 30-day post-irradiation survival. Delta-Tocotrienol increased cell survival, and regeneration of hematopoietic microfoci and lineage(-)/Sca-1(+)/ckit(+) stem and progenitor cells in irradiated mouse bone marrow, and protected human CD34(+) cells from radiation-induced damage. Delta-Tocotrienol activated extracellular signal-related kinase 1/2 phosphorylation and significantly inhibited formation of DNA-damage marker γ-H2AX foci. In addition, Delta-Tocotrienol up-regulated mammalian target of rapamycin and phosphorylation of its downstream effector 4EBP-1. These alterations were associated with activation of mRNA translation regulator eIF4E and ribosomal protein S6, which is responsible for cell survival and growth. Inhibition of extracellular signal-related kinase 1/2 expression by short interfering RNA abrogated Delta-Tocotrienol -induced mammalian target of rapamycin phosphorylation and clonogenicity, and increased γ-H2AX foci formation in irradiated CD34(+) cells.
CONCLUSIONS:
Our data indicate that Delta-Tocotrienol protects mouse bone marrow and human CD34(+) cells from radiation-induced damage through extracellular signal-related kinase activation-associated mammalian target of rapamycin survival pathways. | | Int J Cancer. 2012 Dec 1;131(11):2668-77. | | Effect of delta-tocotrienol and grape seed polyphenol on lipid profile in c57bl/6j mice with a western-like diet-induced non-alcoholic steatohepatitis[Reference: WebLink] | Non-alcoholic steatohepatitis (NASH), the second phase in liver disease, occurs when adults consume high calorie, high fat diets. Fat accumulated in the liver causes inflammation and irreversible hardening. Grape seed polyphenol (GSP) and Delta-Tocotrienol (d-T3) may have benefits in reducing NASH.
METHODS AND RESULTS:
We observed the effects of dietary GSP & d-T3 (separated and combined: GSP - 2%; d-T3 - 0.05%) in C57BL/6J mice fed a high calorie high fat diet for 20 weeks. Hepatic cholesterol, triglycerides, and vitamin E; serum cholesterol, triglycerides, vitamin E, and free fatty acids were assayed. Hepatic total cholesterol was lowest in GSP diet and GSP(2%)+dT3(0.05%) diet groups. Hepatic triglycerides were lowest in the GSP(2%)+dT3(0.05%) diet group. Hepatic vitamin E levels were lowest in the GSP(2%)+dT3(0.05%) diet group. Serum cholesterol was lowest in GSP diet and GSP(2%)+dT3(0.05%) diet groups. Serum vitamin E was lowest in the GSP diet group. Serum triglycerides and FFA's were similar among the groups. |
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