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  • Beta-生育三烯酚

    • Beta-生育三烯酚

    Beta-Tocotrienol

    Beta-生育三烯酚
    		产品编号 CFN92822
    CAS编号 490-23-3
    分子式 = 分子量 C28H42O2 = 410.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The stem barks of Garcinia virgata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Beta-生育三烯酚 CFN92822 490-23-3 1mg QQ客服：1457312923
    Beta-生育三烯酚 CFN92822 490-23-3 5mg QQ客服：1457312923
    Beta-生育三烯酚 CFN92822 490-23-3 10mg QQ客服：1457312923
    Beta-生育三烯酚 CFN92822 490-23-3 20mg QQ客服：1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Hertfordshire (United Kingdom)
  • Anna University (India)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Mendel University in Brno (Czech Republic)
  • Weizmann Institute of Science (Israel)
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  • Universiti Sains Malaysia (Malaysia)
  • Chungnam National University (Korea)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Am J Chin Med.2016, 44(8):1719-1735
  • Research J. Pharm. and Tech.2020, 13(7):3059-3064.
  • Molecules.2023, 28(8):3474.
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Industrial Crops and Products2023, 199:116746.
  • Antioxidants (Basel).2022, 11(8):1471.
  • Srinakharinwirot University2023, 2669.
  • Proc Biol Sci.2024, 291(2015):20232578.
  • Anal Bioanal Chem. 2016, 408(15)
  • PLoS One.2018, 13(4):e0195642
  • Cell Death Discov.2023, 9(1):350.
  • Neurotoxicology.2022, 91:218-227.
  • Postharvest Biol Tec2019, 149:18-26
  • Antioxidants.2022, 11(4), 67.
  • JEJU National University2022, 10478.
  • Process Biochemistry2019, 87:213-220
  • J Sep Sci.2023, 46(16):e2300160.
  • Nat Commun.2019, 10(1):2745
  • Eur J Pharmacol.2018, 832:96-103
  • Molecules.2016, 21(6)
  • VNU Journal of Science2023, 39(2):24-33.
  • Sci Rep.2018, 8:15059
  • ...
    • 生物活性
    Description: Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations.
    Targets: Caspase
    In vitro:
    Biomed Pharmacother. 2014 Oct;68(8):1105-15.
    Antiproliferation and induction of caspase-8-dependent mitochondria-mediated apoptosis by β-tocotrienol in human lung and brain cancer cell lines.[Pubmed: 25456851]
    The pure vitamin isomer, Beta-Tocotrienol has the least abundance among the other vitamin E isomers that are present in numerous plants. Hence, it is very scarcely studied for its bioactivity.
    METHODS AND RESULTS:
    In this study, the antiproliferative effects and primary apoptotic mechanisms of Beta-Tocotrienol on human lung adenocarcinoma A549 and glioblastoma U87MG cells were investigated. It was evidenced that Beta-Tocotrienol had inhibited the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations. Cancer cells incubated with Beta-Tocotrienol were also found to exhibit hallmarks of apoptotic morphologies including membrane blebbing, chromatin condensation and formation of apoptotic bodies. The apoptotic properties of Beta-Tocotrienol in both A549 and U87MG cells were the results of its capability to induce significant (P<0.05) double-strand DNA breaks (DSBs) without involving single-strand DNA breaks (SSBs). Beta-Tocotrienol is said to induce activation of caspase-8 in both A549 and U87MG cells guided by no activation when caspase-8 inhibitor, z-IETD-fmk was added. Besides, disruption on the mitochondrial membrane permeability of the cells in a concentration- and time-dependent manner had occurred.
    CONCLUSIONS:
    The induction of apoptosis by Beta-Tocotrienol in A549 and U87MG cells was confirmed to involve both the death-receptor mediated and mitochondria-dependent apoptotic pathways. These findings could potentiate the palm oil derived Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4355 mL 12.1773 mL 24.3546 mL 48.7092 mL 60.8865 mL
    5 mM 0.4871 mL 2.4355 mL 4.8709 mL 9.7418 mL 12.1773 mL
    10 mM 0.2435 mL 1.2177 mL 2.4355 mL 4.8709 mL 6.0887 mL
    50 mM 0.0487 mL 0.2435 mL 0.4871 mL 0.9742 mL 1.2177 mL
    100 mM 0.0244 mL 0.1218 mL 0.2435 mL 0.4871 mL 0.6089 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去羟基-Delta-生育酚，2,8-二甲基-2-(4,8,12-三甲基十三烷基)-2H-1-苯并吡喃-6-醇; Dehydro-Delta-tocopherol CFN97674 802909-72-4 C27H44O2 = 400.65 5mg QQ客服：215959384
    (+)-Delta-生育酚; (+)-Delta-Tocopherol CFN91145 119-13-1 C27H46O2 = 402.7 5mg QQ客服：3257982914
    Confluentin; Confluentin CFN98991 585534-03-8 C22H30O2 = 326.5 5mg QQ客服：1457312923
    Daurichromenic acid; Daurichromenic acid CFN97302 82003-90-5 C23H30O4 = 370.5 5mg QQ客服：2056216494
    Beta-生育三烯酚; Beta-Tocotrienol CFN92822 490-23-3 C28H42O2 = 410.6 5mg QQ客服：1413575084
    5,8-二甲基母育酚/维生素E; Beta-Tocopherol CFN96393 148-03-8 C28H48O2 = 416.7 5mg QQ客服：3257982914
    (+)-gamma-生育酚; (+)-gamma-Tocopherol CFN91685 54-28-4 C28H48O2 = 416.7 5mg QQ客服：1413575084
    Gamma-生育三烯酚; Gamma-Tocotrienol CFN92817 14101-61-2 C28H42O2 = 410.6 5mg QQ客服：3257982914
    Alpha-生育三烯酚; Alpha-Tocotrienol CFN92821 1721-51-3 C29H44O2 = 424.7 5mg QQ客服：2159513211
    天然维生素E; DL-alpha-Tocopherol CFN90041 59-02-9 C29H50O2 = 430.7 20mg QQ客服：215959384

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