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  • 日本前胡醇


    产品编号 CFN90496
    CAS编号 23458-02-8
    分子式 = 分子量 C14H14O4 = 246.26
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica gigas.
    产品名称 产品编号 CAS编号 包装 QQ客服
    日本前胡醇 CFN90496 23458-02-8 10mg QQ客服:3257982914
    日本前胡醇 CFN90496 23458-02-8 20mg QQ客服:3257982914
    日本前胡醇 CFN90496 23458-02-8 50mg QQ客服:3257982914
    日本前胡醇 CFN90496 23458-02-8 100mg QQ客服:3257982914
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    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

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  • ...
  • 生物活性
    Description: Decursinol may be a beneficial antimetastatic agent, targeting MMPs and its upstream signaling molecules; it inhibits the proliferation and invasion of CT-26 colon carcinoma cells, might via downregulated ERK and JNK phosphorylation. Aspirin-decursinol has neuroprotective effects, may be closely related to the attenuation of ischemia-induced gliosis and maintenance of antioxidants.
    Targets: NADPH-oxidase | P450 (e.g. CYP17) | ERK | JNK | MMP(e.g.TIMP)
    In vitro:
    Planta Med. 2013 Nov;79(16):1536-44.
    In vitro metabolism of pyranocoumarin isomers decursin and decursinol angelate by liver microsomes from man and rodents.[Pubmed: 24026903]
    The aim of this study is to investigate and compare the metabolic rate and profiles of pyranocoumarin isomers decursin and decursinol angelate using liver microsomes from humans and rodents, and to characterize the major metabolites of decursin and decursinol angelate in human liver microsomal incubations using LC-MS/MS.
    First, we conducted liver microsomal incubations of decursin and decursinol angelate in the presence or absence of NADPH. We found that in the absence of NADPH, decursin was efficiently hydrolyzed to decursinol by hepatic esterase(s), but decursinol angelate was not. In contrast, formation of decursinol from decursinol angelate was mediated mainly by cytochrome P450(s). Second, we measured the metabolic rate of decursin and decursinol angelate in liver S9 fractions from mice and humans. We found that human liver S9 fractions metabolized both decursin and decursinol angelate more slowly than those of the mouse. Third, we characterized the major metabolites of decursin and decursinol angelate from human liver microsomes incubations using HPLC-UV and LC-MS/MS methods and assessed the in vivo metabolites in mouse plasma from a one-dose PK study. Decursin and decursinol angelate have different metabolite profiles.
    Nine metabolites of decursin and nine metabolites of decursinol angelate were identified in human liver microsome incubations besides decursinol using a hybrid triple quadruple linear ion trap LC-MS/MS system, and many of them were later verified to be also present in plasma samples from rodent PK studies.
    In vivo:
    PLoS One. 2015 Feb 19;10(2):e0114992.
    Single oral dose pharmacokinetics of decursin and decursinol angelate in healthy adult men and women.[Pubmed: 25695490]
    The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans.
    To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (Tmax) of 2.1, 2.4 and 3.3 h and mean peak concentration (Cmax) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t1/2) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC0-48h) for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents.
    Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0607 mL 20.3037 mL 40.6075 mL 81.215 mL 101.5187 mL
    5 mM 0.8121 mL 4.0607 mL 8.1215 mL 16.243 mL 20.3037 mL
    10 mM 0.4061 mL 2.0304 mL 4.0607 mL 8.1215 mL 10.1519 mL
    50 mM 0.0812 mL 0.4061 mL 0.8121 mL 1.6243 mL 2.0304 mL
    100 mM 0.0406 mL 0.203 mL 0.4061 mL 0.8121 mL 1.0152 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    紫花前胡素D; Decursitin D CFN95002 245446-61-1 C19H20O6 = 344.4 5mg QQ客服:3257982914
    乙酰基二氢美味草素A; Acetyldihydromicromelin A CFN97520 94285-22-0 C17H16O7 = 332.3 5mg QQ客服:2159513211
    小芸木素; Micromelin CFN99629 15085-71-9 C15H12O6 = 288.3 5mg QQ客服:215959384
    Hydramicromelin B; Hydramicromelin B CFN89277 369391-55-9 C15H14O7 = 306.27 5mg QQ客服:2056216494
    Hydramicromelin D; Hydramicromelin D CFN89265 1623437-86-4 C15H14O7 = 306.27 5mg QQ客服:2056216494
    花椒树皮素甲; Xanthyletin CFN96429 553-19-5 C14H12O3 = 228.24 5mg QQ客服:215959384
    黄木亭; Xanthoxyletin CFN96284 84-99-1 C15H14O4 = 258.3 5mg QQ客服:2056216494
    10-甲氧基-8,8-二甲基-2H,8H-苯并[1,2-b:5,4-b']二吡喃-2-酮; Luvangetin CFN89243 483-92-1 C15H14O4 = 258.27 5mg QQ客服:2056216494
    去甲基鲁望桔内酯; Demethylluvangetin CFN89286 64652-10-4 C14H12O4 = 244.24 5mg QQ客服:2159513211
    3'-Hydroxyxanthyletin; 3'-Hydroxyxanthyletin CFN91704 165900-08-3 C14H12O4 = 244.2 5mg QQ客服:1413575084





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