日本前胡醇

Decursinol

	产品编号	CFN90496
	CAS编号	23458-02-8
	分子式 = 分子量	C₁₄H₁₄O₄ = 246.26
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The roots of Angelica gigas.
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产品名称	产品编号	CAS编号	包装	QQ客服
日本前胡醇	CFN90496	23458-02-8	10mg	QQ客服：3257982914
日本前胡醇	CFN90496	23458-02-8	20mg	QQ客服：3257982914
日本前胡醇	CFN90496	23458-02-8	50mg	QQ客服：3257982914
日本前胡醇	CFN90496	23458-02-8	100mg	QQ客服：3257982914

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Description:

Decursinol may be a beneficial antimetastatic agent, targeting MMPs and its upstream signaling molecules; it inhibits the proliferation and invasion of CT-26 colon carcinoma cells, might via downregulated ERK and JNK phosphorylation. Aspirin-decursinol has neuroprotective effects, may be closely related to the attenuation of ischemia-induced gliosis and maintenance of antioxidants.

Targets:

NADPH-oxidase | P450 (e.g. CYP17) | ERK | JNK | MMP(e.g.TIMP)

In vitro:

Planta Med. 2013 Nov;79(16):1536-44.

In vitro metabolism of pyranocoumarin isomers decursin and decursinol angelate by liver microsomes from man and rodents.[Pubmed: 24026903]

The aim of this study is to investigate and compare the metabolic rate and profiles of pyranocoumarin isomers decursin and decursinol angelate using liver microsomes from humans and rodents, and to characterize the major metabolites of decursin and decursinol angelate in human liver microsomal incubations using LC-MS/MS.
METHODS AND RESULTS:
First, we conducted liver microsomal incubations of decursin and decursinol angelate in the presence or absence of NADPH. We found that in the absence of NADPH, decursin was efficiently hydrolyzed to decursinol by hepatic esterase(s), but decursinol angelate was not. In contrast, formation of decursinol from decursinol angelate was mediated mainly by cytochrome P450(s). Second, we measured the metabolic rate of decursin and decursinol angelate in liver S9 fractions from mice and humans. We found that human liver S9 fractions metabolized both decursin and decursinol angelate more slowly than those of the mouse. Third, we characterized the major metabolites of decursin and decursinol angelate from human liver microsomes incubations using HPLC-UV and LC-MS/MS methods and assessed the in vivo metabolites in mouse plasma from a one-dose PK study. Decursin and decursinol angelate have different metabolite profiles.
CONCLUSIONS:
Nine metabolites of decursin and nine metabolites of decursinol angelate were identified in human liver microsome incubations besides decursinol using a hybrid triple quadruple linear ion trap LC-MS/MS system, and many of them were later verified to be also present in plasma samples from rodent PK studies.

In vivo:

PLoS One. 2015 Feb 19;10(2):e0114992.

Single oral dose pharmacokinetics of decursin and decursinol angelate in healthy adult men and women.[Pubmed: 25695490]

The ethanol extract of Angelica gigas Nakai (AGN) root has promising anti-cancer and other bioactivities in rodent models. It is currently believed that the pyranocoumarin isomers decursin (D) and decursinol angelate (DA) contribute to these activities. We and others have documented that D and DA were rapidly converted to decursinol (DOH) in rodents. However, our in vitro metabolism studies suggested that D and DA might be metabolized differently in humans.
METHODS AND RESULTS:
To test this hypothesis and address a key question for human translatability of animal model studies of D and DA or AGN extract, we conducted a single oral dose human pharmacokinetic study of D and DA delivered through an AGN-based dietary supplement Cogni.Q (purchased from Quality of Life Labs, Purchase, NY) in twenty healthy subjects, i.e., 10 men and 10 women, each consuming 119 mg D and 77 mg DA from 4 vegicaps. Analyses of plasma samples using UHPLC-MS/MS showed mean time to peak concentration (Tmax) of 2.1, 2.4 and 3.3 h and mean peak concentration (Cmax) of 5.3, 48.1 and 2,480 nmol/L for D, DA and DOH, respectively. The terminal elimination half-life (t1/2) for D and DA was similar (17.4 and 19.3 h) and each was much longer than that of DOH (7.4 h). The mean area under the curve (AUC0-48h) for D, DA and DOH was estimated as 37, 335 and 27,579 h∙nmol/L, respectively. Gender-wise, men absorbed the parent compounds faster and took shorter time to reach DOH peak concentration. The human data supported an extensive conversion of D and DA to DOH, even though they metabolized DA slightly slower than rodents.
CONCLUSIONS:
Therefore, the data generated in rodent models concerning anti-cancer efficacy, safety, tissue distribution and pharmacodynamic biomarkers will likely be relevant for human translation.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
乙酰基二氢美味草素A; Acetyldihydromicromelin A	CFN97520	94285-22-0	C₁₇H₁₆O₇ = 332.3	5mg	QQ客服：2159513211
小芸木素; Micromelin	CFN99629	15085-71-9	C₁₅H₁₂O₆ = 288.3	5mg	QQ客服：1413575084
Hydramicromelin B; Hydramicromelin B	CFN89277	369391-55-9	C₁₅H₁₄O₇ = 306.27	5mg	QQ客服：1457312923
Hydramicromelin D; Hydramicromelin D	CFN89265	1623437-86-4	C₁₅H₁₄O₇ = 306.27	5mg	QQ客服：2159513211
花椒树皮素甲; Xanthyletin	CFN96429	553-19-5	C₁₄H₁₂O₃ = 228.24	5mg	QQ客服：1413575084
黄木亭; Xanthoxyletin	CFN96284	84-99-1	C₁₅H₁₄O₄ = 258.3	5mg	QQ客服：2159513211
10-甲氧基-8,8-二甲基-2H,8H-苯并[1,2-b:5,4-b']二吡喃-2-酮; Luvangetin	CFN89243	483-92-1	C₁₅H₁₄O₄ = 258.27	5mg	QQ客服：1457312923
去甲基鲁望桔内酯; Demethylluvangetin	CFN89286	64652-10-4	C₁₄H₁₂O₄ = 244.24	5mg	QQ客服：1413575084
3'-Hydroxyxanthyletin; 3'-Hydroxyxanthyletin	CFN91704	165900-08-3	C₁₄H₁₂O₄ = 244.2	5mg	QQ客服：1457312923
3',4'-二氢-3'-羟基-花椒内酯; 3',4'-dihydro-3'-hydroxy-Xanthyletin	CFN92775	5993-18-0	C₁₄H₁₄O₄ = 246.3	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0607 mL	20.3037 mL	40.6075 mL	81.215 mL	101.5187 mL
5 mM	0.8121 mL	4.0607 mL	8.1215 mL	16.243 mL	20.3037 mL
10 mM	0.4061 mL	2.0304 mL	4.0607 mL	8.1215 mL	10.1519 mL
50 mM	0.0812 mL	0.4061 mL	0.8121 mL	1.6243 mL	2.0304 mL
100 mM	0.0406 mL	0.203 mL	0.4061 mL	0.8121 mL	1.0152 mL

日本前胡醇

Decursinol

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