| Description: |
Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced gastric ulcers in rats and guinea pigs. |
| Targets: |
NO | PGE | COX | Antifection |
| In vitro: |
| Pharm Biol. 2017 Dec;55(1):1195-1201. | | Anti-inflammatory coumarins from Paramignya trimera.[Pubmed: 28245363 ] |
METHODS AND RESULTS:
Seven coumarins were isolated and identified as: ostruthin (1), ninhvanin (2), 8-geranyl-7-hydroxycoumarin (3), 6-(6',7'-dihydroxy-3',7'-dimethylocta-2'-enyl)-7-hydroxycoumarin (4), 6-(7-hydroperoxy-3,7-dimethylocta-2,5-dienyl)-7-hydroxycoumarin (5), 6-(2-hydroxyethyl)-2,2-dimethyl-2H-1-benzopyran (6), and Luvangetin (7). Compounds 1-4 and 7 inhibited NO and PGE2 production in LPS-stimulated BV2 cells, with IC50 values ranging from 9.8 to 46.8 and from 9.4 to 52.8 μM, respectively. Ostruthin (1) and ninhvanin (2) were shown to suppress LPS-induced iNOS and COX-2 protein expression.
CONCLUSIONS:
The present study provides a scientific rationale for the use of P. trimera in the prevention and treatment of neuroinflammatory diseases. Ostruthin and ninhvanin might have potential therapeutic effects and should be considered for further development as new anti-neuroinflammatory agents. |
|
| In vivo: |
| Indian J Exp Biol. 1997 Oct;35(10):1080-3. | | Antiulcer activity of naturally occurring pyrano-coumarin and isocoumarins and their effect on prostanoid synthesis using human colonic mucosa.[Pubmed: 9475044] |
METHODS AND RESULTS:
Oral administration of bergenin and norbergenin, two isocoumarins, isolated from the leaves and roots of Flueggea microcarpa and Luvangetin, a pyranocoumarin isolated from the seeds of Aegle marmelos Correa, showed significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rats and cold restraint stress-induced gastric ulcers in rats and guinea pigs. The study on prostaglandins release by human colonic mucosal incubates, indicated a concentration-dependent (1-10 micrograms/ml) stimulatory effect of bergenin and norbergenin, while Luvangetin (1-10 micrograms/ml) did not produce any effect.
CONCLUSIONS:
The results suggest that gastroprotective effects of bergenin and norbergenin could be due to increased prostaglandin production while, some other mucosal defensive factors may be involved for Luvangetin. |
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![10-甲氧基-8,8-二甲基-2H,8H-苯并[1,2-b:5,4-b']二吡喃-2-酮](https://www.chemfaces.com/structural/Luvangetin-CFN89243.jpg)
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