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  • 木香烃内酯

    Costunolide

    木香烃内酯
    产品编号 CFN98928
    CAS编号 553-21-9
    分子式 = 分子量 C15H20O2 = 232.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Inula helenium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    木香烃内酯 CFN98928 553-21-9 10mg QQ客服:2056216494
    木香烃内酯 CFN98928 553-21-9 20mg QQ客服:2056216494
    木香烃内酯 CFN98928 553-21-9 50mg QQ客服:2056216494
    木香烃内酯 CFN98928 553-21-9 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Parma (Italy)
  • Univerzita Karlova v Praze (Czech Republic)
  • University of Beira Interior (Portugal)
  • Universidade do Porto (Portugal)
  • Wageningen University (Netherlands)
  • Universit?t Basel (Switzerland)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Max-Planck-Insitut (Germany)
  • Agricultural Research Organization (ARO) (Israel)
  • Periyar University (India)
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  • National Cancer Institute (USA)
  • FORTH-IMBB (Greece)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2017, 22(6)
  • Life (Basel).2022, 12(10):1630.
  • LWT2021, 147:111620.
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Biosci Rep.2018, 38(4)
  • J Formos Med Assoc.2020, S0929-6646(20)30425-3
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • J Cell Mol Med . 2023, jcmm.17954.
  • The Journal of Supercritical Fluids2021, 176:105305.
  • Int J Mol Sci.2018, 19(9):E2601
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • Molecules.2019, 25(1):E103
  • Institute of Food Science & Technology2021, 18 December.
  • Molecules.2021, 26(16):4722.
  • RSC Adv.2018, 32621-32636
  • BMC Complement Altern Med.2016, 16:213
  • Evid Based Complement Alternat Med.2021, 2021:5585692.
  • Korean J of Food Science&Technology 2017, 49(2):146-150
  • Foods.2020, 9(10):1348.
  • Pak J Pharm Sci.2018, 31:311-315
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • LWT2020, 124:109163
  • Psychopharmacology (Berl).2020, 10.1007
  • ...
  • 生物活性
    Description: Costunolide has antipyretic, anti-inflammatory, anti-oxidant, anti-carcinogenic and anti-fungal activities, it possesses normo-glycemic and hypolipidemic activity. Costunolide inhibits RANKL-induced osteoclast differentiation by suppressing RANKL-mediated c-Fos transcriptional activity; it inhibits IL-1beta gene expression by blocking the activation of MAPKs and DNA binding of AP-1; it also induces the ROS-mediated mitochondrial permeability transition and resultant cytochrome c release,
    Targets: NF-kB | p65 | ROS | AP-1 | IL Receptor | p38MAPK | JNK | LDL | Chk | c-Fos | AP-1
    In vitro:
    Phytother Res. 2014 Oct;28(10):1499-505.
    In vitro and in silico evaluation of NF-κB targeted costunolide action on estrogen receptor-negative breast cancer cells--a comparison with normal breast cells.[Pubmed: 24733523]
    Costunolide, a sesquiterpene lactone is a plant-derived secondary metabolite found to be present in most of the pharmacologically active herbs, being the cause for their medicinal values. The present study aims to evaluate the cytotoxic effect of costunolide isolated from Costus speciosus rhizome extract on MDA-MB-231 cells and explore its targeted action in comparison with its action on the normal breast cells (MCF 10A).
    METHODS AND RESULTS:
    The effect of costunolide on cell viability of the cells was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide viability assay. The targeted action of the compound was analyzed comparing the effectiveness of the compound to alter the protein expression levels of NF-κB subunits in the normal and the cancer cells using western blotting analysis. In silico studies were performed to predict the targeted interaction of costunolide with the NF-κB subunit proteins. Costunolide inhibited the cell viability of MDA-MB-231 cells in a dose-dependent manner leaving no significant change in the viability of the normal breast cells. The over expressed NF-κB subunits - p65, 52 and 100 in the cancer cells were found to be downregulated when treated with costunolide at an effective dose of 20 and 40 μM costunolide. In silico results provided stable interactions between costunolide and the target proteins, supporting the in vitro results in addition.
    CONCLUSIONS:
    Thus, costunolide derived from C. speciosus plant source elevates a fresh conviction for its use in breast cancer therapy for its cytotoxic efficacy and non-toxic nature.
    Biochem Biophys Res Commun. 2004 Jan 2;313(1):171-7.
    Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells.[Pubmed: 14672714]
    Costunolide, a sesquiterpene lactone isolated from the root of Saussurea lappa Clarke, is known to have a variety of biological activities, including anti-carcinogenic and anti-fungal activities.
    METHODS AND RESULTS:
    Here, we demonstrated the inhibitory effect of costunolide on the protein and mRNA expression of interleukin-1beta (IL-1beta) in LPS-stimulated RAW 264.7 cells. We also showed that costunolide suppressed the transcriptional activity of the IL-1beta promoter. Moreover, costunolide inhibited the activity of AP-1 transcription factor, and the phosphorylation of MAPKs, including SAPK/JNK and p38 MAP kinase. The inhibitory effect of costunolide on AP-1 activity was also confirmed by an electrophoretic mobility shift assay. Additionally, specific inhibitors of SAPK/JNK and p38 MAP kinase, SP600125 and SB203580, also suppressed LPS-induced increase in IL-1beta gene expression and AP-1 DNA binding.
    CONCLUSIONS:
    Taken together, these results demonstrate that costunolide inhibits IL-1beta gene expression by blocking the activation of MAPKs and DNA binding of AP-1 in LPS-stimulated RAW 264.7 cells.
    2019 Jun 14;20(12):2926.
    Costunolide-A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential[Pubmed: 31208018]
    Sesquiterpene lactones constitute a major class of bioactive natural products. One of the naturally occurring sesquiterpene lactones is costunolide, which has been extensively investigated for a wide range of biological activities. Multiple lines of preclinical studies have reported that the compound possesses antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Many of these bioactivities are supported by mechanistic details, such as the modulation of various intracellular signaling pathways involved in precipitating tissue inflammation, tumor growth and progression, bone loss, and neurodegeneration. The key molecular targets of costunolide include, but are not limited to, intracellular kinases, such as mitogen-activated protein kinases, Akt kinase, telomerase, cyclins and cyclin-dependent kinases, and redox-regulated transcription factors, such as nuclear factor-kappaB, signal transducer and activator of transcription, activator protein-1. The compound also diminished the production and/expression of proinflammatory mediators, such as cyclooxygenase-2, inducible nitric oxide synthase, nitric oxide, prostaglandins, and cytokines. This review provides an overview of the therapeutic potential of costunolide in the management of various diseases and their underlying mechanisms. Keywords: anti-allergic; anti-inflammatory; anticancer; antidiabetic properties; antimicrobial; antioxidants; bone regenerating; costunolide; hair growth promoting; neuroprotective.
    In vivo:
    J Ethnopharmacol. 2009 Jul 30;124(3):369-76.
    Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae).[Pubmed: 19524658 ]
    Magnolia ovata (A.St.-Hil.) Spreng (formerly Talauma ovata), known as "pinha-do-brejo" or "baguaçu", is a large tree widely distributed in Brazil. Its trunk bark has been used in folk medicine against fever. However, no data have been published to support the antipyretic ethnopharmacological use. This study investigated the antipyretic and anti-inflammatory effects of the ethanolic extract (EEMO), dichloromethane fraction (DCM), and the isolated compound costunolide.
    METHODS AND RESULTS:
    The antipyretic and anti-inflammatory activities were evaluated in experimental models of fever and inflammation in mice. The oral administration of EEMO, DCM and costunolide inhibited carrageenan (Cg)-induced paw oedema (ID(50) 72.35 (38.64-135.46) mg/kg, 5.8 (2.41-14.04) mg/kg and 0.18 (0.12-0.27) mg/kg, respectively) and was effective in abolishing lipopolysaccharide (LPS)-induced fever (30 mg/kg, 4.5 mg/kg and 0.15 mg/kg, respectively). EEMO was also effective in reducing cell migration in the pleurisy model. Intraplantar injection of costunolide also reduced the paw oedema, myeloperoxidase and N-acetyl-glucosaminidase activity induced by Cg in mice.
    CONCLUSIONS:
    Collectively, these results show, for the first time, that extracts obtained from Magnolia ovata possess antipyretic and anti-inflammatory properties, and costunolide appears to be the compound responsible for these effects.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.3048 mL 21.5239 mL 43.0478 mL 86.0956 mL 107.6195 mL
    5 mM 0.861 mL 4.3048 mL 8.6096 mL 17.2191 mL 21.5239 mL
    10 mM 0.4305 mL 2.1524 mL 4.3048 mL 8.6096 mL 10.7619 mL
    50 mM 0.0861 mL 0.4305 mL 0.861 mL 1.7219 mL 2.1524 mL
    100 mM 0.043 mL 0.2152 mL 0.4305 mL 0.861 mL 1.0762 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2alpha-羟基泽兰内酯; 2-Hydroxyeupatolide CFN90346 72229-33-5 C15H20O4 = 264.32 5mg QQ客服:3257982914
    表美国鹅掌楸内酯; Epitulipinolide CFN98252 24164-13-4 C17H22O4 = 290.4 5mg QQ客服:1457312923
    小白菊内酯; Parthenolide CFN98034 20554-84-1 C15H20O3 = 248.3 20mg QQ客服:2056216494
    鹅掌揪内酯; Lipiferolide CFN98642 41059-80-7 C17H22O5 = 306.4 5mg QQ客服:2056216494
    环氧表美国鹅掌楸内酯; Epitulipinolide diepoxide CFN98630 39815-40-2 C17H22O6 = 322.4 5mg QQ客服:3257982914
    Heliangin; Heliangin CFN96222 13323-48-3 C20H26O6 = 362.4 5mg QQ客服:3257982914
    8beta-(4-Hydroxytigloyloxy)ovatifolin; 8beta-(4-Hydroxytigloyloxy)ovatifolin CFN96820 554449-27-3 C22H28O7 = 404.45 5mg QQ客服:2159513211
    Demethylsonchifolin; Demethylsonchifolin CFN97591 956384-55-7 C20H24O6 = 360.41 5mg QQ客服:2056216494
    Uvedalin; Uvedalin CFN97776 24694-79-9 C23H28O9 = 448.47 5mg QQ客服:1413575084
    沼菊素氯海德林; Enhydrin chlorohydrin CFN97746 38230-99-8 C23H29ClO10 = 500.93 5mg QQ客服:1413575084

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