剑叶龙血素C
Cochinchinenin C
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 剑叶龙血素C |
CFN98503 |
956103-79-0 |
1mg |
QQ客服：2159513211 |
| 剑叶龙血素C |
CFN98503 |
956103-79-0 |
5mg |
QQ客服：2159513211 |
| 剑叶龙血素C |
CFN98503 |
956103-79-0 |
10mg |
QQ客服：2159513211 |
| 剑叶龙血素C |
CFN98503 |
956103-79-0 |
20mg |
QQ客服：2159513211 |
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Food Research2021, 5(1):65-71
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TCI CO.2019, US20190151281A1
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Planta Med.2018, 84(6-07):465-474
| Description: |
There is a synergistic interaction between loureirin A and Cochinchinenin C, and the fluorescence quenching of HSA by loureirin A (or Cochinchinenin C) is a combined quenching procedure (dynamic and static quenching). |
| In vitro: |
| Eur J Med Chem. 2015 Mar 26;93:492-500. | | Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.[Pubmed: 25734332] |
METHODS AND RESULTS:
The interactions of loureirin A (LA) and Cochinchinenin C (CC) with human serum albumin (HSA) under simulated physiological conditions (pH = 7.4) have been studied with fluorescence, UV-vis absorption spectroscopic method and molecular docking technique. The results indicated that there was a synergistic interaction between LA and Cochinchinenin C, and the fluorescence quenching of HSA by LA (or Cochinchinenin C) was a combined quenching procedure (dynamic and static quenching). At low compound concentrations, the quenching constants KSV of Cochinchinenin C was larger than that of LA, which meant the Cochinchinenin C efficacy may be better than that of LA. The negative △H and △S values suggested hydrogen bonds and van der Waals forces played the major role in the binding of LA (or Cochinchinenin C) to HSA.
CONCLUSIONS:
The efficiency of energy transfer and distance between the compounds and HSA was calculated. Moreover, the results of synchronous and three-dimensional fluorescence demonstrated that the HSA microenvironment was changed in the presence of LA (or Cochinchinenin C). Finally, the binding of LA (or Cochinchinenin C) to HSA was modeled by molecular docking, which is in good accordance with the experimental studies. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.8429 mL |
9.2146 mL |
18.4291 mL |
36.8582 mL |
46.0728 mL |
| 5 mM |
0.3686 mL |
1.8429 mL |
3.6858 mL |
7.3716 mL |
9.2146 mL |
| 10 mM |
0.1843 mL |
0.9215 mL |
1.8429 mL |
3.6858 mL |
4.6073 mL |
| 50 mM |
0.0369 mL |
0.1843 mL |
0.3686 mL |
0.7372 mL |
0.9215 mL |
| 100 mM |
0.0184 mL |
0.0921 mL |
0.1843 mL |
0.3686 mL |
0.4607 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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