剑叶龙血素C

Cochinchinenin C

	产品编号	CFN98503
	CAS编号	956103-79-0
	分子式 = 分子量	C₃₃H₃₄O₇ = 542.62
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Chalcones
	植物来源	From Daemonorops draco Bl.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
剑叶龙血素C	CFN98503	956103-79-0	1mg	QQ客服：1413575084
剑叶龙血素C	CFN98503	956103-79-0	5mg	QQ客服：1413575084
剑叶龙血素C	CFN98503	956103-79-0	10mg	QQ客服：1413575084
剑叶龙血素C	CFN98503	956103-79-0	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

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National Cancer Institute (USA)

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Monash University Malaysia (Malaysia)

The University of Newcastle (Australia)

Universidade de Franca (Brazil)

Osmania University (India)

University of Oslo (Norway)

Utrecht University (Netherlands)

Sri Ramachandra University (India)

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Description:

There is a synergistic interaction between loureirin A and Cochinchinenin C, and the fluorescence quenching of HSA by loureirin A (or Cochinchinenin C) is a combined quenching procedure (dynamic and static quenching).

In vitro:

Eur J Med Chem. 2015 Mar 26;93:492-500.

Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin.[Pubmed: 25734332]

METHODS AND RESULTS:
The interactions of loureirin A (LA) and Cochinchinenin C (CC) with human serum albumin (HSA) under simulated physiological conditions (pH = 7.4) have been studied with fluorescence, UV-vis absorption spectroscopic method and molecular docking technique. The results indicated that there was a synergistic interaction between LA and Cochinchinenin C, and the fluorescence quenching of HSA by LA (or Cochinchinenin C) was a combined quenching procedure (dynamic and static quenching). At low compound concentrations, the quenching constants KSV of Cochinchinenin C was larger than that of LA, which meant the Cochinchinenin C efficacy may be better than that of LA. The negative △H and △S values suggested hydrogen bonds and van der Waals forces played the major role in the binding of LA (or Cochinchinenin C) to HSA.
CONCLUSIONS:
The efficiency of energy transfer and distance between the compounds and HSA was calculated. Moreover, the results of synchronous and three-dimensional fluorescence demonstrated that the HSA microenvironment was changed in the presence of LA (or Cochinchinenin C). Finally, the binding of LA (or Cochinchinenin C) to HSA was modeled by molecular docking, which is in good accordance with the experimental studies.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Calyxin H; Calyxin H	CFN98024	202596-22-3	C₃₅H₃₄O₇ = 566.7	5mg	QQ客服：1457312923
剑叶龙血素A; Cochinchinenin A	CFN90769	221696-69-1	C₁₇H₁₈O₄ = 286.3	20mg	QQ客服：3257982914
剑叶龙血素C; Cochinchinenin C	CFN98503	956103-79-0	C₃₃H₃₄O₇ = 542.62	5mg	QQ客服：3257982914
Sarcandrone A; Sarcandrone A	CFN99299	1190225-47-8	C₃₃H₃₀O₈ = 554.6	5mg	QQ客服：1457312923
Sarcandrone B; Sarcandrone B	CFN99300	1190225-48-9	C₃₃H₃₀O₈ = 554.6	5mg	QQ客服：2056216494
Calyxin B; Calyxin B	CFN99693	164991-53-1	C₃₅H₃₄O₈ = 582.7	5mg	QQ客服：1413575084
Galanganone A; Galanganone A	CFN89196	1922129-42-7	C₃₂H₃₆O₆ = 516.63	5mg	QQ客服：1413575084
Galanganone B; Galanganone B	CFN89197	1922129-43-8	C₃₄H₄₀O₆ = 544.68	5mg	QQ客服：3257982914
Galanganone C; Galanganone C	CFN89198	1922129-46-1	C₃₂H₃₆O₅ = 500.63	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8429 mL	9.2146 mL	18.4291 mL	36.8582 mL	46.0728 mL
5 mM	0.3686 mL	1.8429 mL	3.6858 mL	7.3716 mL	9.2146 mL
10 mM	0.1843 mL	0.9215 mL	1.8429 mL	3.6858 mL	4.6073 mL
50 mM	0.0369 mL	0.1843 mL	0.3686 mL	0.7372 mL	0.9215 mL
100 mM	0.0184 mL	0.0921 mL	0.1843 mL	0.3686 mL	0.4607 mL