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  • Calyxin B

    Calyxin B

    Calyxin B
    产品编号 CFN99693
    CAS编号 164991-53-1
    分子式 = 分子量 C35H34O8 = 582.7
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The herbs of Alpinia galanga
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Calyxin B CFN99693 164991-53-1 1mg QQ客服:1413575084
    Calyxin B CFN99693 164991-53-1 5mg QQ客服:1413575084
    Calyxin B CFN99693 164991-53-1 10mg QQ客服:1413575084
    Calyxin B CFN99693 164991-53-1 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biol Pharm Bull.2021, 44(12):1891-1893.
  • Sci Rep.2017, 7(1):3249
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  • Pharmaceutics.2020, 12(9):845.
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  • Front Microbiol.2020, 11:583594.
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  • Front Cell Dev Biol.2021, 9:588093.
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  • Appl. Sci. 2021, 11(10),4666.
  • Life Sci.2022, 298:120488.
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  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • J Biochem Mol Toxicol.2020, 34(7):e22489.
  • Phytomedicine.2019, 61:152813
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Nat Plants.2016, 3:16205
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  • Agronomy2020, 10(10),1489
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  • ...
  • 生物活性
    Description: Calyxin B exhibits potent activity against human HT-1080 fibrosarcoma cells with an ED50 value of 0.69 microM. A methylated product of calyxin A and an epimeric mixture of Calyxin B, showed greatly reduced activity suggesting that phenolic hydroxyl groups are involved in the inhibitory activity.
    Targets: NO
    In vitro:
    Biol Pharm Bull. 1998 Apr;21(4):371-4.
    Inhibitory effect of diarylheptanoids on nitric oxide production in activated murine macrophages.[Pubmed: 9586575]

    METHODS AND RESULTS:
    Thirteen novel diarylheptanoids bearing a chalcone or a flavanone moiety (1-13), a new curcumin derivative, 1,2-dihydrobis(de-O-methyl)curcumin (14), and two known flavonoids (15 and 16) isolated from the seeds of Alpinia blepharocalyx K. Schum. were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccaride (LPS)-activated murine macrophages J774.1 in vitro. All the tested compounds inhibited NO production in a concentration-dependent manner (IC50=36-568 microM). Among the compounds examined, blepharoCalyxin B (13) was the most potent inhibitor of NO production (IC50=36 microM).
    CONCLUSIONS:
    Analysis of the structure activity relationship among these novel diarylheptanoids led to the conclusion that the position of attachment of a chalcone or a flavanone to a diarylheptanoid does not affect their inhibitory potency although their presence in association causes a substantial enhancement of the inhibitory activity. Moreover, a conjugated double bond in a chalcone moiety potentiated the inhibitory activity. On the other hand, hexamethoxydeoxycalyxin A (17) and pentamethoxyCalyxin B (18), a methylated product of calyxin A (1) and an epimeric mixture of Calyxin B, showed greatly reduced activity suggesting that phenolic hydroxyl groups are involved in the inhibitory activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7161 mL 8.5807 mL 17.1615 mL 34.323 mL 42.9037 mL
    5 mM 0.3432 mL 1.7161 mL 3.4323 mL 6.8646 mL 8.5807 mL
    10 mM 0.1716 mL 0.8581 mL 1.7161 mL 3.4323 mL 4.2904 mL
    50 mM 0.0343 mL 0.1716 mL 0.3432 mL 0.6865 mL 0.8581 mL
    100 mM 0.0172 mL 0.0858 mL 0.1716 mL 0.3432 mL 0.429 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Calyxin H; Calyxin H CFN98024 202596-22-3 C35H34O7 = 566.7 5mg QQ客服:1413575084
    剑叶龙血素A; Cochinchinenin A CFN90769 221696-69-1 C17H18O4 = 286.3 20mg QQ客服:2159513211
    剑叶龙血素C; Cochinchinenin C CFN98503 956103-79-0 C33H34O7 = 542.62 5mg QQ客服:215959384
    Sarcandrone A; Sarcandrone A CFN99299 1190225-47-8 C33H30O8 = 554.6 5mg QQ客服:3257982914
    Sarcandrone B; Sarcandrone B CFN99300 1190225-48-9 C33H30O8 = 554.6 5mg QQ客服:1148253675
    Calyxin B; Calyxin B CFN99693 164991-53-1 C35H34O8 = 582.7 5mg QQ客服:1148253675
    Galanganone A; Galanganone A CFN89196 1922129-42-7 C32H36O6 = 516.63 5mg QQ客服:2932563308
    Galanganone B; Galanganone B CFN89197 1922129-43-8 C34H40O6 = 544.68 5mg QQ客服:3257982914
    Galanganone C; Galanganone C CFN89198 1922129-46-1 C32H36O5 = 500.63 5mg QQ客服:2932563308

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