Calyxin B

	产品编号	CFN99693
	CAS编号	164991-53-1
	分子式 = 分子量	C₃₅H₃₄O₈ = 582.7
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Chalcones
	植物来源	The herbs of Alpinia galanga
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Calyxin B	CFN99693	164991-53-1	1mg	QQ客服：215959384
Calyxin B	CFN99693	164991-53-1	5mg	QQ客服：215959384
Calyxin B	CFN99693	164991-53-1	10mg	QQ客服：215959384
Calyxin B	CFN99693	164991-53-1	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Toronto (Canada)

University of Zurich (Switzerland)

University of Maryland School of Medicine (USA)

University of Melbourne (Australia)

Auburn University (USA)

Center for protein Engineering (CIP) (Belgium)

Max Rubner-Institut (MRI) (Germany)

Nanjing University of Chinese Medicine (China)

University of Illinois at Chicago (USA)

Universidad de Buenos Aires (Argentina)

Worcester Polytechnic Institute (USA)

Korea Food Research Institute(KFRI) (Korea)

Kyung Hee University (Korea)

University of Wisconsin-Madison (USA)

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Description:

Calyxin B exhibits potent activity against human HT-1080 fibrosarcoma cells with an ED50 value of 0.69 microM. A methylated product of calyxin A and an epimeric mixture of Calyxin B, showed greatly reduced activity suggesting that phenolic hydroxyl groups are involved in the inhibitory activity.

Targets:

In vitro:

Biol Pharm Bull. 1998 Apr;21(4):371-4.

Inhibitory effect of diarylheptanoids on nitric oxide production in activated murine macrophages.[Pubmed: 9586575]

METHODS AND RESULTS:
Thirteen novel diarylheptanoids bearing a chalcone or a flavanone moiety (1-13), a new curcumin derivative, 1,2-dihydrobis(de-O-methyl)curcumin (14), and two known flavonoids (15 and 16) isolated from the seeds of Alpinia blepharocalyx K. Schum. were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccaride (LPS)-activated murine macrophages J774.1 in vitro. All the tested compounds inhibited NO production in a concentration-dependent manner (IC50=36-568 microM). Among the compounds examined, blepharoCalyxin B (13) was the most potent inhibitor of NO production (IC50=36 microM).
CONCLUSIONS:
Analysis of the structure activity relationship among these novel diarylheptanoids led to the conclusion that the position of attachment of a chalcone or a flavanone to a diarylheptanoid does not affect their inhibitory potency although their presence in association causes a substantial enhancement of the inhibitory activity. Moreover, a conjugated double bond in a chalcone moiety potentiated the inhibitory activity. On the other hand, hexamethoxydeoxycalyxin A (17) and pentamethoxyCalyxin B (18), a methylated product of calyxin A (1) and an epimeric mixture of Calyxin B, showed greatly reduced activity suggesting that phenolic hydroxyl groups are involved in the inhibitory activity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Calyxin H; Calyxin H	CFN98024	202596-22-3	C₃₅H₃₄O₇ = 566.7	5mg	QQ客服：3257982914
剑叶龙血素A; Cochinchinenin A	CFN90769	221696-69-1	C₁₇H₁₈O₄ = 286.3	20mg	QQ客服：215959384
剑叶龙血素C; Cochinchinenin C	CFN98503	956103-79-0	C₃₃H₃₄O₇ = 542.62	5mg	QQ客服：2056216494
Sarcandrone A; Sarcandrone A	CFN99299	1190225-47-8	C₃₃H₃₀O₈ = 554.6	5mg	QQ客服：3257982914
Sarcandrone B; Sarcandrone B	CFN99300	1190225-48-9	C₃₃H₃₀O₈ = 554.6	5mg	QQ客服：2159513211
Calyxin B; Calyxin B	CFN99693	164991-53-1	C₃₅H₃₄O₈ = 582.7	5mg	QQ客服：2159513211
Galanganone A; Galanganone A	CFN89196	1922129-42-7	C₃₂H₃₆O₆ = 516.63	5mg	QQ客服：1457312923
Galanganone B; Galanganone B	CFN89197	1922129-43-8	C₃₄H₄₀O₆ = 544.68	5mg	QQ客服：2159513211
Galanganone C; Galanganone C	CFN89198	1922129-46-1	C₃₂H₃₆O₅ = 500.63	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7161 mL	8.5807 mL	17.1615 mL	34.323 mL	42.9037 mL
5 mM	0.3432 mL	1.7161 mL	3.4323 mL	6.8646 mL	8.5807 mL
10 mM	0.1716 mL	0.8581 mL	1.7161 mL	3.4323 mL	4.2904 mL
50 mM	0.0343 mL	0.1716 mL	0.3432 mL	0.6865 mL	0.8581 mL
100 mM	0.0172 mL	0.0858 mL	0.1716 mL	0.3432 mL	0.429 mL