| In vitro: |
| Natural Product Research & Development, 2014, 26(6):851-833. | | Phenolic Constituents from Rhizome of Wikstroemia indica and Their Anti-tumor Activity.[Reference: WebLink] |
METHODS AND RESULTS:
Seventeen phenolic constituents were isolated from the rhizome of Wikstroemia indica using a combination of various chromatographic methods. Their structures were elucidated and identified as wikstromol( 1),matairesinol( 2),syringaresinol( 3),pinoresinol( 4),isolariciresinol( 5),Ciwujiatone( 6),isorhamnetin-3-O-robinobioside( 7),wikstaiwanone A( 8),wikstaiwanone B( 9),kaempferol( 10),rutin( 11),daphnoretin( 12),triumbelletin( 13),alnusdiol( 14),aloe-emodin-8-O-β-D-glucoside( 15),chlorogenic acid( 16) and p-hydroxybenzoic acid( 17) by physicochemical properties and spectral data including NMR and MS. Compounds 3-9 and 13-16 were isolated from this plant for the first time.
CONCLUSIONS:
The anti-tumor tests showed compounds 1-4,6-9 exhibited different activities against colon cancer cell lines SW480 and SW620,in which compound 6 showed most significant activities against the two cell lines. |
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