| In vitro: |
| Arch. Pharm. Res.,2014 Apr;37(4):467-72. | | A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects.[Pubmed: 24014307 ] |
METHODS AND RESULTS:
A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8'R)-acuminatolide (6), and (+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol (9-O-Feruloyl-5,5'-dimethoxylariciresinol,7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chemical reaction, and the absolute configuration of 1 was determined by Mosher's esterification. The effect of compounds 1-7 on tumor necrosis factor (TNF)-α, interleukin(IL)-6, and their inhibitory activity of histamine release were examined using human mast cells. Among the lignans tested, compounds 1, 3, 4, 6, and 7 inhibited release of histamine from mast cells. Especially, compounds 1 and 4 suppressed the gene expressions of pro-inflammatory cytokines, TNF-α, and IL-6 in human mast cells.
CONCLUSIONS:
Our findings suggest that the lignan constituents in L. obtusiloba may contribute to its anti-allergic inflammatory effects. |
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