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  • 猫眼草酚D; 5,3',4'-三羟基-3,6,7-三甲氧基黄酮

    Chrysosplenol D

    猫眼草酚D; 5,3',4'-三羟基-3,6,7-三甲氧基黄酮
    产品编号 CFN99622
    CAS编号 14965-20-9
    分子式 = 分子量 C18H16O8 = 360.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Artemisia annua L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    猫眼草酚D; 5,3',4'-三羟基-3,6,7-三甲氧基黄酮 CFN99622 14965-20-9 1mg QQ客服:2159513211
    猫眼草酚D; 5,3',4'-三羟基-3,6,7-三甲氧基黄酮 CFN99622 14965-20-9 5mg QQ客服:2159513211
    猫眼草酚D; 5,3',4'-三羟基-3,6,7-三甲氧基黄酮 CFN99622 14965-20-9 10mg QQ客服:2159513211
    猫眼草酚D; 5,3',4'-三羟基-3,6,7-三甲氧基黄酮 CFN99622 14965-20-9 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Gdański (Poland)
  • University of Auckland (New Zealand)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Regional Crop Research Institute (Korea)
  • Mahidol University (Thailand)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Medical University of Gdansk (Poland)
  • Amity University (India)
  • University of British Columbia (Canada)
  • University of Amsterdam (Netherlands)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Griffith University (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Natural Product Communications2020, doi: 10.1177.
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • BMB Rep.2018, 51(5):249-254
  • Molecules.2022, 27(4):1412.
  • Pharmacognosy Journal.2020, 12(2), p232-235.
  • Eur J Pharm Sci.2016, 94:33-45
  • Int J Mol Sci.2021, 22(12):6466.
  • Phytomedicine.2022, 99:153997.
  • Int J Mol Sci.2021, 22(11):5503.
  • Toxins (Basel).2020, 12(4):210.
  • Nutrients.2022, 14(19):4170.
  • Cell Rep.2020, 32(11):108158.
  • Journal of Apicultural Research2021, 60(1)
  • QASCF2022, 14(4).
  • J Ethnopharmacol.2017, 206:73-77
  • Molecules.2022, 27(22):7997.
  • Molecules.2019, 24(21):E3834
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Acta Biochim Pol.2015, 62(2):253-8
  • J Biol Chem.2014, 289(3):1723-31
  • Arch Biochem Biophys.2018, 644:93-99
  • Inflammation.2020, 43(5):1716-1728.
  • US20170000760 A12016, 42740
  • ...
  • 生物活性
    Description: Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials. Chrysosplenol D has anti-inflammatory, antimalarial, antibacterial and antifungal activities; it also exerts its anti-proliferative effect on tsFT210 cells through inhibiting cell cycle and inducing apoptosis, it may as a new cell cycle inhibitor.
    Targets: NF-kB | JNK | IkB | IL Receptor | IKK | Antifection
    In vitro:
    Plant Cell Rep. 1992 Nov;11(12):637-40.
    Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures.[Pubmed: 24213368 ]
    Cell suspension cultures developed from Artemisia annua exhibited antimalarial activity against Plasmodium faldparum in vitro both in the n-hexane extract of the plant cell culture medium and in the chloroform extract of the cells.
    METHODS AND RESULTS:
    Trace amounts of the antimalarial sesquiterpene lactone artemisinin may account for the activity of the n-hexane fraction but only the methoxylated flavonoids artemetin, chrysoplenetin, chrysosplenol-D and cirsilineol can account for the activity of the chloroform extract. These purified flavonoids were found to have IC50 values at 2.4 - 6.5 × 10(-5)M against P. falciparum in vitro compared with an IC50 value of about 3 × 10(-8)M for purified artimisinin.
    CONCLUSIONS:
    At concentrations of 5 × 10(-6)M these flavonoids were not active against P. falciparum but did have a marked and selective potentiating effect on the antiplasmodial activity of artemisinin.
    Phytochemistry, 1989, 28(9):2323-7.
    Antimicrobial flavonoids from Psiadia trinervia and their methylated and acetylated derivatives.[Reference: WebLink]
    From a dichloromethane extract and a hydrolysed methanolic extract from the leaves of Psiadia trinervia, 13 3-methylated flavonols have been isolated.
    METHODS AND RESULTS:
    Their structures were established by the usual spectroscopic methods (UV, EIMS, 1H and 13C NMR). Ayanin, casticin, chrysosplenol-D and 5,7,4′-trihydroxy-3,8-dimethoxyfiavone were responsible for the antifungal activity found in the preliminary screening. Chrysosplenol D, isokaempferide, 5,7,4′- trihydroxy-3,3′-dimethoxyflavone and 5,7,4′-trihydroxy-3,8-dimethoxyflavone displayed antibacterial activity. Twenty-nine derivatives were prepared by permethylation and selective methylation of the free hydroxyl group at C-5.
    CONCLUSIONS:
    The antimicrobial activities of the isolates and derivatives were determined by bioautographic assays using C. cucumerinum and B. cereus as test organisms.
    Nat Prod Res . 2021 Dec;35(24):5909-5913.
    Anti-inflammatory effect of methoxyflavonoids from Chiliadenus montanus ( Jasonia Montana) growing in Egypt[Pubmed: 32746641]
    Abstract Chiliadenus montanus is a medicinal plant that grows in Sinai Peninsula in Egypt. Phytochemical investigation of C. montanus methanolic extract led to the isolation of five methoxy flavonoids; Chrysosplenol-D (1), 5,7,4'-trihydroxy- 3,3'-dimethoxy flavone (2), 5,7-dihydroxy -3,3',4'-trimethoxyflavone (3), Bonanzin (4), 3,5,6,7,4'-pentamethoxy flavone (5), a sesquiterpene, Cryptomeridiol (6) and stigmast-5,22-dien-3-O-β-D-glucopyranoside (7). The anti-inflammatory activity of compounds 2 and 5 was assessed in vitro on CaCo2 cells stimulated by lipopolysaccharide (LPS). Both compounds downregulated LPS-induced expression of inflammatory cytokines; tumor necrosis factor alpha (TNFα), interleukin 1β (IL1β), nuclear factor kappa B (NFκB), cyclooxygenase 1 (Cox1), cyclooxygenase 2 (Cox2), and 5-lipoxygenase (5Lox). In vivo, both compounds significantly decreased paw edema thickness in rats relative to carrageenan, showing better anti-inflammatory activity than celecoxib (36.98%) after 1 h (46.60% and 48.11%, respectively). An in silico study was performed, where both compounds were docked into the active site of the crystal structure of the human Cox2 enzyme. Keywords: Chiliadenus montanus; colorectal cancer; cytokines; docking; methoxyflavonoids.
    Int J Mol Sci . 2020 Jun 8;21(11):4090.
    Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells[Pubmed: 32521698]
    Abstract Triple negative human breast cancer (TNBC) is an aggressive cancer subtype with poor prognosis. Besides the better-known artemisinin, Artemisia annua L. contains numerous active compounds not well-studied yet. High-performance liquid chromatography coupled with diode-array and mass spectrometric detection (HPLC-DAD-MS) was used for the analysis of the most abundant compounds of an Artemisia annua extract exhibiting toxicity to MDA-MB-231 TNBC cells. Artemisinin, 6,7-dimethoxycoumarin, arteannuic acid were not toxic to any of the cancer cell lines tested. The flavonols chrysosplenol d and casticin selectively inhibited the viability of the TNBC cell lines, MDA-MB-231, CAL-51, CAL-148, as well as MCF7, A549, MIA PaCa-2, and PC-3. PC-3 prostate cancer cells exhibiting high basal protein kinase B (AKT) and no ERK1/2 activation were relatively resistant, whereas MDA-MB-231 cells with high basal ERK1/2 and low AKT activity were more sensitive to chrysosplenol d treatment. In vivo, chrysosplenol d and casticin inhibited MDA-MB-231 tumor growth on chick chorioallantoic membranes. Both compounds induced mitochondrial membrane potential loss and apoptosis. Chrysosplenol d activated ERK1/2, but not other kinases tested, increased cytosolic reactive oxygen species (ROS) and induced autophagy in MDA-MB-231 cells. Lysosomal aberrations and toxicity could be antagonized by ERK1/2 inhibition. The Artemisia annua flavonols chrysosplenol d and casticin merit exploration as potential anticancer therapeutics. Keywords: apoptosis; artemisia annua; casticin; cell cycle; chick chorioallantoic membrane assay; chrysosplenol d; methoxylated flavonoids; mitogen-activated protein kinase; triple negative breast cancer.
    Fitoterapia . 2018 Mar;125:191-198.
    Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima[Pubmed: 29108932]
    Abstract In previous studies the aerial parts of Achillea fragrantissima were found to have substantial antileishmanial and antitrypanosomal activity. A bioassay-guided fractionation of a dichloromethane extract yielded the isolation of the essential anti-trypanosomal compounds of the plant. Seven sesquiterpene lactones (including Achillolide-A), two flavonoids, chrysosplenol-D and chrysosplenetine, and four alkamides (including pellitorine) were identified. This is the first report for the isolation of the sesquiterpene lactones 3 and 4, chrysosplenetine and the group of alkamides from this plant. Bioevaluation against Trypanosoma brucei brucei TC221 (T.b brucei) using the Alamar-Blue assay revealed the novel alkamide 13 to have an IC50 value of 40.37μM. A compound library, derived from the alkamide pellitorine (10), was synthesized and bioevaluated in order to find even more active substances. The most active compounds 26 and 27 showed activities in submicromolar concentrations and selectivity indices of 20.1 and 45.6, respectively, towards macrophage cell line J774.1. Toxicity of 26 and 27 was assessed using the greater wax moth Galleria mellonella larvae as an in vivo model. No significant toxicity was observed for the concentration range of 1.25-20mM. Keywords: Achillea fragrantissima; Alkamides; Anti-trypanosomal; Flavonoids; Sesquiterpene lactones.
    In vivo:
    Toxicol Appl Pharmacol. 2015 Apr 17.
    Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo.[Pubmed: 25891417]
    The aim of our experiments was to investigate the anti-inflammatory properties of casticin and Chrysosplenol D, two flavonoids present in Artemisia annua L.
    METHODS AND RESULTS:
    Topical inflammation was induced in ICR mice using croton oil. Mice were then treated with casticin or Chrysosplenol D. Cutaneous histological changes and edema were assessed. ICR mice were intragastrically administrated with casticin or Chrysosplenol D followed by intraperitoneal injection of lipopolysaccharide (LPS). Mouse Raw264.7 macrophage cells were incubated with casticin or Chrysosplenol D. Intracellular phosphorylation was detected, and migration was assessed by trans-well assay. HT-29/NFκB-luc cells were incubated with casticin or Chrysosplenol D in the presence or absence of LPS, and NF-κB activation was quantified. In mice, administration of casticin (0.5, 1 and 1.5μmol/cm2) and Chrysosplenol D (1 and 1.5μmol/cm2) inhibited croton oil-induced ear edema (casticin: 29.39-64.95%; Chrysosplenol D: 37.76-65.89%, all P<0.05) in a manner similar to indomethacin (0.5, 1 and 1.5μmol/cm2; 55.63-84.58%). Casticin (0.07, 0.13 and 0.27mmol/kg) and Chrysosplenol D (0.07, 0.14 and 0.28mmol/kg) protected against LPS-induced systemic inflammatory response syndrome (SIRS) in mice (all P<0.05), in a manner similar to dexamethasone (0.03mmol/kg). Casticin and Chrysosplenol D suppressed LPS-induced release of IL-1 beta, IL-6 and MCP-1, inhibited cell migration, and reduced LPS-induced IκB and c-JUN phosphorylation in Raw264.7 cells. JNK inhibitor SP600125 blocked the inhibitory effect of Chrysosplenol D on cytokine release.
    CONCLUSIONS:
    The flavonoids casticin and Chrysosplenol D from A. annua L. inhibited inflammation in vitro and in vivo.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7755 mL 13.8773 mL 27.7546 mL 55.5093 mL 69.3866 mL
    5 mM 0.5551 mL 2.7755 mL 5.5509 mL 11.1019 mL 13.8773 mL
    10 mM 0.2775 mL 1.3877 mL 2.7755 mL 5.5509 mL 6.9387 mL
    50 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.1102 mL 1.3877 mL
    100 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.5551 mL 0.6939 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    棉花皮素 3-甲醚; Gossypetin 3-methylether CFN70462 86749-51-1 C16H12O8 = 332.3 5mg QQ客服:2159513211
    Eupatoletin; Eupatoletin CFN92698 29536-44-5 C17H14O8 = 346.3 5mg QQ客服:2159513211
    猫眼草酚D; 5,3',4'-三羟基-3,6,7-三甲氧基黄酮; Chrysosplenol D CFN99622 14965-20-9 C18H16O8 = 360.3 10mg QQ客服:3257982914
    3'',4'',5,7-四羟基 3,6,8-三甲氧基黄酮; 3'',4'',5,7-Tetrahydroxy 3,6,8-trimethoxyflavone CFN70422 61451-85-2 C18H16O9 = 376.3 5mg QQ客服:2159513211
    柽柳黄素; Tamarixetin CFN97027 603-61-2 C16H12O7 = 316.3 5mg QQ客服:2056216494
    槲皮素3,4'-二甲醚; 5,7,3'-三羟基-3,4'-二甲氧基黄酮; Quercetin 3,4'-dimethyl ether CFN98429 33429-83-3 C17H14O7 = 330.3 5mg QQ客服:1413575084
    商陆素; 3,5 ,3'-三羟基-7,4'-二甲氧基黄酮; Ombuin CFN98876 529-40-8 C17H14O7 = 330.3 5mg QQ客服:1457312923
    阿亚黄素,缎木素; Ayanin CFN96157 572-32-7 C18H16O7 = 344.3 10mg QQ客服:2159513211
    矢车菊黄素; Centaureidin CFN90433 17313-52-9 C18H16O8 = 360.31 5mg QQ客服:1457312923
    甲氧基万寿菊素; Axillarin CFN89530 5188-73-8 C17H14O8 = 346.28 5mg QQ客服:3257982914

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