头花千金藤二酮B

Cepharadione B

	产品编号	CFN94151
	CAS编号	55610-02-1
	分子式 = 分子量	C₁₉H₁₅NO₄ = 321.33
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The roots of Stephania cepharantha Hayata
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
头花千金藤二酮B	CFN94151	55610-02-1	1mg	QQ客服：1413575084
头花千金藤二酮B	CFN94151	55610-02-1	5mg	QQ客服：1413575084
头花千金藤二酮B	CFN94151	55610-02-1	10mg	QQ客服：1413575084
头花千金藤二酮B	CFN94151	55610-02-1	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Seoul National University (Korea)

Complutense University of Madrid (Spain)

Aarhus University (Denmark)

Colorado State University (USA)

University of Auckland (New Zealand)

FORTH-IMBB (Greece)

Massachusetts General Hospital (USA)

Max-Planck-Insitut (Germany)

Kyoto University (Japan)

Sant Gadge Baba Amravati University (India)

Utrecht University (Netherlands)

Medical University of South Carolina (USA)

Washington State University (USA)

China Medical University (Taiwan)

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Description:

Cepharadione B exhibits strong tyrosinase inhibitory activity with an IC50 value of 170 microM. It also exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.

Targets:

Tyrosinase

In vitro:

Chem. Pharm. Bull. (Tokyo)., 2009 ,57(11):1227-30.

The constituents and their bioactivities of Houttuynia cordata.[Pubmed: 19881272]

METHODS AND RESULTS:
Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type 1 (HSV-1) assay, norcepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of some isolated compounds were also evaluated.
CONCLUSIONS:
Among these compounds, quercitrin (25) and quercetin-3-O-beta-D-galactopyranoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 microM, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 microM.

Arch. Pharm.Res., 2001, 24(6):518-21.

Cytotoxic alkaloids from Houttuynia cordata.[Pubmed: 11794526]

METHODS AND RESULTS:
Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata.
CONCLUSIONS:
Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
1,2,3,10-Tetramethoxy-9-(2-hydroxy-4,5-dimethoxybenzyloxy)oxoaporphine; 1,2,3,10-Tetramethoxy-9-(2-hydroxy-4,5-dimethoxybenzyloxy)oxoaporphine	CFN89548	872729-33-4	C₂₉H₂₇NO₉ = 533.52	5mg	QQ客服：3257982914
去甲头花千金藤二酮B; Norcepharadione B	CFN98975	57576-41-7	C₁₈H₁₃NO₄ = 307.3	5mg	QQ客服：1413575084
Aristoliukine B; Aristoliukine B	CFN91874	217310-32-2	C₁₇H₁₁NO₅ = 309.27	5mg	QQ客服：1413575084
头花千金藤二酮B; Cepharadione B	CFN94151	55610-02-1	C₁₉H₁₅NO₄ = 321.33	5mg	QQ客服：2159513211
头花千金藤二酮A; Cepharadione A	CFN96041	55610-01-0	C₁₈H₁₁NO₄ = 305.3	5mg	QQ客服：3257982914
番荔枝碱; (-)-Anonaine	CFN91018	1862-41-5	C₁₇H₁₅NO₂ = 265.31	5mg	QQ客服：1457312923
莲碱; Roemerine	CFN91019	548-08-3	C₁₈H₁₇NO₂ = 279.33	5mg	QQ客服：2159513211
瓜馥木碱甲; Fissistigine A	CFN91767	70420-58-5	C₁₈H₁₇NO₄ = 311.33	5mg	QQ客服：2056216494
Laetanine; Laetanine	CFN93031	72361-67-2	C₁₈H₁₉NO₄ = 313.35	10mg	QQ客服：2159513211
去甲异波尔定; Laurolitsine	CFN90492	5890-18-6	C₁₈H₁₉NO₄ = 313.34	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1121 mL	15.5603 mL	31.1207 mL	62.2413 mL	77.8016 mL
5 mM	0.6224 mL	3.1121 mL	6.2241 mL	12.4483 mL	15.5603 mL
10 mM	0.3112 mL	1.556 mL	3.1121 mL	6.2241 mL	7.7802 mL
50 mM	0.0622 mL	0.3112 mL	0.6224 mL	1.2448 mL	1.556 mL
100 mM	0.0311 mL	0.1556 mL	0.3112 mL	0.6224 mL	0.778 mL