番荔枝碱

(-)-Anonaine

	产品编号	CFN91018
	CAS编号	1862-41-5
	分子式 = 分子量	C₁₇H₁₅NO₂ = 265.31
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The leaves of Nelumbo nucifera
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
番荔枝碱	CFN91018	1862-41-5	1mg	QQ客服：2159513211
番荔枝碱	CFN91018	1862-41-5	5mg	QQ客服：2159513211
番荔枝碱	CFN91018	1862-41-5	10mg	QQ客服：2159513211
番荔枝碱	CFN91018	1862-41-5	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Parma (Italy)

University of Leipzig (Germany)

Centralised Purchases Unit (CPU), B.I.T.S (India)

Monash University Malaysia (Malaysia)

University of Madras (India)

Universidade da Beira Interior (Germany)

Max Rubner-Institut (MRI) (Germany)

Sapienza University of Rome (Italy)

Sanford Burnham Prebys Medical Discovery Institute (USA)

Charles Sturt University (Denmark)

Universidad Industrial de Santander (Colombia)

Weizmann Institute of Science (Israel)

Universiti Malaysia Pahang (Malaysia)

University of Sao Paulo (Brazil)

More...

Description:

(-)-Anonaine has some anticancer activity, it induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells, it induces DNA damage and inhibits growth and migration of human lung carcinoma h1299 cells. (-)-Anonaine may be considered a potent compound for chemotherapy against cervical cancer or a health food supplement for cancer chemoprevention. (-)-Anonaine has vasorelaxant effect.

Targets:

In vitro:

Planta Med. 2004 Jul;70(7):603-9.

Vascular activity of (-)-anonaine, (-)-roemerine and (-)-pukateine, three natural 6a(R)-1,2-methylenedioxyaporphines with different affinities for alpha1-adrenoceptor subtypes.[Pubmed: 15254852 ]

We have studied the mechanism of action of three 6a( R)-1,2-methylenedioxyaporphines as vasorelaxant compounds.
METHODS AND RESULTS:
The alkaloids assayed showed different affinities for the three human cloned alpha (1)-adrenoceptor (AR) subtypes stably expressed in rat-1 fibroblasts, showing lower affinity for alpha(1B)-AR with regard to the alpha(1A)- or alpha(1D)-subtypes. These three natural compounds are more potent inhibitors of [ (3)H]-prazosin binding than of [ (3)H]-diltiazem binding to rat cerebral cortical membranes. As all these alkaloids inhibited noradrenaline (NA)-induced [ (3)H]-inositol phosphate formation in cerebral cortex and rat tail artery, they may be safely viewed as alpha (1)-AR antagonists, as is demonstrated by the vasorelaxant responses observed in isolated rat tail artery and/or aorta precontracted with NA. The alkaloids also inhibited the contractile response evoked by KCl (80 mM) but with a lower potency than that shown against NA-induced contraction. We have also examined their ability to inhibit the different forms of cyclic nucleotide phosphodiesterases (PDE) isolated from bovine aortic smooth muscle and endothelial cells, with negative results.
CONCLUSIONS:
We conclude that N-methylation favours the interaction of (R)-aporphines with all alpha (1)-AR subtypes, and that the topography of the binding site recognizing the basic or protonated nitrogen atom is similar in all three alpha (1)-AR subtypes. The presence of a hydroxy group at C-11 has different effects on the affinity for each alpha (1)-AR subtype but decreases the affinity for Ca (2+) channels. These results confirm and extend the view that subtle changes in the hydroxylation patterns on the aromatic ring of the aporphine structure affect the interactions of these compounds with the three alpha (1)-AR subtypes in different ways, suggesting that the binding site recognizing the aporphine skeleton is different in each of the three subtypes..

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Aristoliukine B; Aristoliukine B	CFN91874	217310-32-2	C₁₇H₁₁NO₅ = 309.27	5mg	QQ客服：2159513211
头花千金藤二酮B; Cepharadione B	CFN94151	55610-02-1	C₁₉H₁₅NO₄ = 321.33	5mg	QQ客服：1413575084
头花千金藤二酮A; Cepharadione A	CFN96041	55610-01-0	C₁₈H₁₁NO₄ = 305.3	5mg	QQ客服：1457312923
番荔枝碱; (-)-Anonaine	CFN91018	1862-41-5	C₁₇H₁₅NO₂ = 265.31	5mg	QQ客服：215959384
莲碱; Roemerine	CFN91019	548-08-3	C₁₈H₁₇NO₂ = 279.33	5mg	QQ客服：1457312923
瓜馥木碱甲; Fissistigine A	CFN91767	70420-58-5	C₁₈H₁₇NO₄ = 311.33	5mg	QQ客服：1457312923
Laetanine; Laetanine	CFN93031	72361-67-2	C₁₈H₁₉NO₄ = 313.35	10mg	QQ客服：1413575084
去甲异波尔定; Laurolitsine	CFN90492	5890-18-6	C₁₈H₁₉NO₄ = 313.34	5mg	QQ客服：2056216494
去甲异波尔定; Norisoboldine	CFN99528	23599-69-1	C₁₈H₁₉NO₄ = 313.35	20mg	QQ客服：3257982914
去甲海罂粟碱盐酸盐; Norglaucine hydrochloride	CFN96271	39945-41-0	C₂₀H₂₄ClNO₄ = 377.9	5mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.7692 mL	18.8459 mL	37.6918 mL	75.3835 mL	94.2294 mL
5 mM	0.7538 mL	3.7692 mL	7.5384 mL	15.0767 mL	18.8459 mL
10 mM	0.3769 mL	1.8846 mL	3.7692 mL	7.5384 mL	9.4229 mL
50 mM	0.0754 mL	0.3769 mL	0.7538 mL	1.5077 mL	1.8846 mL
100 mM	0.0377 mL	0.1885 mL	0.3769 mL	0.7538 mL	0.9423 mL

番荔枝碱

(-)-Anonaine

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