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  • (-)-二氢槲皮素

    (-)-Dihydroquercetin

    (-)-二氢槲皮素
    产品编号 CFN92413
    CAS编号 111003-33-9
    分子式 = 分子量 C15H12O7 = 304.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Xanthoceras sorbifolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (-)-二氢槲皮素 CFN92413 111003-33-9 1mg QQ客服:1413575084
    (-)-二氢槲皮素 CFN92413 111003-33-9 5mg QQ客服:1413575084
    (-)-二氢槲皮素 CFN92413 111003-33-9 10mg QQ客服:1413575084
    (-)-二氢槲皮素 CFN92413 111003-33-9 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Gyeongsang National University (Korea)
  • University of Zurich (Switzerland)
  • Chiang Mai University (Thailand)
  • University of Limpopo (South Africa)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Universite de Lille1 (France)
  • University of Canterbury (New Zealand)
  • University of Toronto (Canada)
  • University of Brasilia (Brazil)
  • Biotech R&D Institute (USA)
  • National Research Council of Canada (Canada)
  • Sri Ramachandra University (India)
  • University of Virginia (USA)
  • University of Bonn (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Life Sci.2021, 286:120019.
  • Phytomedicine.2022, 110:154597.
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
  • J Chromatogr Sci.2015, 53(5):824-9
  • Int. J. Mol. Sci.2023, 24(20),15294.
  • Nat Prod Communications2018, 10.1177
  • Nutrients.2020, 12(5):1242.
  • Antioxidants (Basel).2021, 10(1):112.
  • University of Stuttgart2021, 11682.
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Nutrients.2023, 15(6):1417.
  • BMC Complement Altern Med.2014, 14:352
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • Molecules.2022, 27(19):6681.
  • Invest New Drugs.2017, 35(2):166-179
  • Nat Prod Commun.2018, 10.1177
  • University of Guelph2021, 12.
  • Drug Dev Res.2020, doi: 10.1002
  • Neurochem Res.2021, s11064-021-03449-0
  • Foods. 2022, 11(23):3905.
  • Research Square2022, rs.3.rs-1948239
  • In Vivo.2022, 36(3):1136-1143.
  • ...
  • 生物活性
    Description: Dihydroquercetin-rich extract (Lavitol) derived from the Dahurian larch tree, used as a food additive and as a dietary supplement ingredient.(+)-Dihydroquercetin has antioxidant activity, exhibits neuroprotective actions against the oxidative injuries induced in cortical cell cultures.
    In vitro:
    Brain Res., 2003, 965(1-2):130-6.
    Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3-methyl ether, isolated from Opuntia ficus-indica var. saboten.[Pubmed: 12591129]
    The flavonoids quercetin, (+)-dihydroquercetin, and quercetin 3-methyl ether were isolated from the ethyl acetate fractions of the fruits and stems of Opuntia ficus-indica var. saboten.
    METHODS AND RESULTS:
    In the present study, we evaluated their protective effects against oxidative neuronal injuries induced in primary cultured rat cortical cells and their antioxidant activities by using three different cell-free bioassays. Quercetin was found to inhibit H(2)O(2)- or xanthine (X)/xanthine oxidase (XO)-induced oxidative neuronal cell injury, with an estimated IC(50) of 4-5 micro g/ml. However, it was no more protective at concentrations of 30 micro g/ml and above. (+)-Dihydroquercetin concentration-dependently inhibited oxidative neuronal injuries, but it was less potent than quercetin. On the other hand, quercetin 3-methyl ether potently and dramatically inhibited H(2)O(2)- and X/XO-induced neuronal injuries, with IC(50) values of 0.6 and 0.7 micro g/ml, respectively. All three principles markedly inhibited lipid peroxidation and scavenged 1,1-diphenyl-2-picrylhydrazyl free radicals. In addition, quercetin and quercetin 3-methyl ether were shown to inhibit XO activity in vitro, with respective IC(50) values of 10.67 and 42.01 micro g/ml.
    CONCLUSIONS:
    These results indicate that quercetin, (+)-dihydroquercetin, and quercetin 3-methyl ether are the active antioxidant principles in the fruits and stems of Opuntia ficus-indica var. saboten exhibiting neuroprotective actions against the oxidative injuries induced in cortical cell cultures. Furthermore, quercetin 3-methyl ether appears to be the most potent neuroprotectant of the three flavonoids isolated from this plant.
    In vivo:
    Int. J.Toxicol., 2015, 34(2): 243-310.
    Toxicological and Genotoxicity Assessment of a Dihydroquercetin-Rich Dahurian Larch Tree (Larix gmelinii Rupr) Extract (Lavitol).[Pubmed: 25850419 ]
    Safety assessment is reported of an orally ingested dihydroquercetin-rich extract (Lavitol) derived from the Dahurian larch tree, used as a food additive and as a dietary supplement ingredient.
    METHODS AND RESULTS:
    Dihydroquercetin, a potent antioxidant, is also known as taxifolin. The results of genotoxicity and toxicological tests (Comet assay, micronucleus test in human lymphocytes, chromosomal aberration test, subacute 7-day oral toxicity study, subchronic 90-day toxicology study with histopathologies, and, prenatal and postnatal developmental toxicity studies) on the extract provide further support for the safety of its consumption as a food supplement and food additive.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2862 mL 16.4312 mL 32.8623 mL 65.7246 mL 82.1558 mL
    5 mM 0.6572 mL 3.2862 mL 6.5725 mL 13.1449 mL 16.4312 mL
    10 mM 0.3286 mL 1.6431 mL 3.2862 mL 6.5725 mL 8.2156 mL
    50 mM 0.0657 mL 0.3286 mL 0.6572 mL 1.3145 mL 1.6431 mL
    100 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.6572 mL 0.8216 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    花旗松素; Taxifolin CFN98734 480-18-2 C15H12O7 = 304.3 20mg QQ客服:1457312923
    李属素; Padmatin CFN97280 80453-44-7 C16H14O7 = 318.3 5mg QQ客服:2056216494
    雪松素 ; Deodarin CFN96563 33788-39-5 C16H14O7 = 318.29 5mg QQ客服:2159513211
    2',3,5,6',7-四羟基二氢黄烷酮; 2',3,5,6',7-Pentahydroxyflavanone CFN97277 80366-15-0 C15H12O7 = 304.3 5mg QQ客服:3257982914
    二氢桑色素; Dihydromorin CFN99854 18422-83-8 C15H12O7 = 304.3 5mg QQ客服:1457312923
    二氢柽柳黄素; Dihydrotamarixetin CFN97194 70411-27-7 C16H14O7 = 318.3 5mg QQ客服:215959384
    艾纳香素B; Blumeatin B CFN97274 79995-67-8 C17H16O7 = 332.3 5mg QQ客服:2159513211
    刺槐亭; Dihydrorobinetin CFN98671 4382-33-6 C15H12O7 = 304.3 5mg QQ客服:1457312923
    蛇葡萄素; 二氢杨梅素; Ampelopsin CFN98326 27200-12-0 C15H12O8 = 320.3 20mg QQ客服:215959384
    Sepinol; Sepinol CFN97204 72061-63-3 C16H14O7 = 318.3 5mg QQ客服:2159513211

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