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  • 斑蝥素

    Cantharidin

    斑蝥素
    产品编号 CFN99790
    CAS编号 56-25-7
    分子式 = 分子量 C10H12O4 = 196.20
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Monoterpenoids
    植物来源 The polypides of Mylabris phalerata Pallas
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    斑蝥素 CFN99790 56-25-7 10mg QQ客服:3257982914
    斑蝥素 CFN99790 56-25-7 20mg QQ客服:3257982914
    斑蝥素 CFN99790 56-25-7 50mg QQ客服:3257982914
    斑蝥素 CFN99790 56-25-7 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • MTT Agrifood Research Finland (Finland)
  • Yale University (USA)
  • University of Wollongong (Australia)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Nanjing University of Chinese Medicine (China)
  • Sapienza University of Rome (Italy)
  • Kazusa DNA Research Institute (Japan)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Mysore (India)
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  • National Chung Hsing University (Taiwan)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • University Medical Center Mainz (Germany)
  • National Research Council of Canada (Canada)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Science and Human Wellness2022, 11(4):965-974
  • Eur J Pharm Sci.2016, 94:33-45
  • J of Essential Oil Research2019, 1677272
  • Plant Physiol Biochem.2021, 160:166-174.
  • PLoS One.2017, 12(3):e0173585
  • Cells.2021, 10(11):2919.
  • Heliyon2020, 6(6):e04337.
  • Phytomedicine.2019, 59:152785
  • Sci Rep.2018, 8(1)
  • Front Cell Infect Microbiol.2018, 8:292
  • Virulence.2018, 9(1):588-603
  • Curr Issues Mol Biol.2022, 44(5):2300-2308.
  • Int J Mol Sci.2019, 20(16):E4015
  • BMC Plant Biol.2018, 18(1):122
  • Int J Oncol.2016, 49(4):1497-504
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • J Nat Med.2017, 71(2):380-388
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Int J Mol Sci.2022, 23(11):6104.
  • Arch Toxicol.2017, 91(10):3225-3245
  • ACS Chem Biol.2019, 14(5):873-881
  • Korean J of Crop Science2019, 452-458
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • ...
  • 生物活性
    Description: Cantharidin, a natural toxicant of blister beetles, is a strong inhibitor of protein phosphatases types 1 (PP1) and 2A (PP2A), and is a novel and potent multidrug resistance (MDR) reversal agent. Cantharidin has anti-tumor activity, it causes oxidative stress that provokes DNA damage and p53-dependent apoptosis, it impairs cell migration and invasion by suppressing MMP-2 and -9 through PI3K/NF-κB signaling pathways.
    Targets: p53 | MMP(e.g.TIMP) | ERK | PI3K | FAK | MMP(e.g.TIMP) | COX | NF-kB | p65 | Rho | ROCK | p38MAPK | JNK | PKC | P-gp
    In vitro:
    Anticancer Res. 2015 Feb;35(2):795-804.
    Cantharidin induces DNA damage and inhibits DNA repair-associated protein expressions in TSGH8301 human bladder cancer cell.[Pubmed: 25667459]
    Cantharidin is an active component of mylabris, which has been used as a traditional Chinese medicine. Cantharidin has been shown to have antitumor activity against several types of human cancers in vitro and in animal models in vivo.
    METHODS AND RESULTS:
    We investigated whether cantharidin induces DNA damage and affects DNA damage repair-associated protein levels in TSGH8301 human bladder cancer cells. Using flow cytometry to measure viable cells, cantharidin was found to reduce the number of viable cells in a dose-dependent manner. Comet assay, 4',6-diamidino-2-phenylindole (DAPI) staining and DNA gel electrophoresis were used to measure DNA damage and condensation; the results indicated that cantharidin induced DNA damage (comet tail), DNA condensation (white DAPI staining) and DNA damage (DNA smear). Results from western blotting showed that cantharidin inhibited the expression of DNA-dependent serine/threonine protein kinase, poly-ADP ribose polymerase, phosphate-ataxia-telangiectasia and RAD3-related, O-6-methylguanine-DNA methyltransferase, breast cancer susceptibility protein 1, mediator of DNA damage checkpoint protein 1, phospho-histone H2A.X, but increased that of phosphorylated p53 following 6 and 24 h treatment. Confocal laser microscopy was used to examine the protein translocation; cantharidin suppressed the levels of p-H2A.X and MDC1 but increased the levels of p-p53 in TSGH8301 cells.
    CONCLUSIONS:
    In conclusion, we found that cantharidin-induced cell death may occur through the induction of DNA damage and suppression of DNA repair-associated protein expression in TSGH8301 cells.
    Cancer Lett. 2008 Dec 8;272(1):102-9.
    Cantharidin reverses multidrug resistance of human hepatoma HepG2/ADM cells via down-regulation of P-glycoprotein expression.[Pubmed: 18703276 ]
    Multidrug resistance (MDR) is a serious obstacle encountered in cancer treatment.
    METHODS AND RESULTS:
    In this study, we established an in vitro multiple drug resistant HepG2 cell line (HepG2/ADM), and characterized its MDR. This model was used to screen potential candidate chemosensitisers from over 200 purified naturally occurring compounds extracted from plants and animals. Cantharidin was found to have a significant reversal on MDR in our model. Further, our results showed that Cantharidin could significantly inhibit P-gp (P-glycoprotein) expression, mRNA transcription, as well as MDR1 promoter activity.
    CONCLUSIONS:
    These results suggest that Cantharidin is a novel and potent MDR reversal agent and may be a potential adjunctive agent for tumor chemotherapy.
    FEBS Lett. 1993 Sep 20;330(3):283-6.
    Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A.[Pubmed: 8397101]
    Cantharidin, a natural toxicant of blister beetles, is a strong inhibitor of protein phosphatases types 1 (PP1) and 2A (PP2A).
    METHODS AND RESULTS:
    Like okadaic acid, cantharidin inhibits the activity of the purified catalytic subunit of PP2A (IC50 = 0.16 microM) at a lower concentration than that of PP1 (IC50 = 1.7 microM) and only inhibits the activity of protein phosphatase type 2B (PP2B) at high concentrations. Dose-inhibition studies conducted with whole cell homogenates indicate that cantharidin also inhibits the native forms of these enzymes.
    CONCLUSIONS:
    Thus, cantharidin, which is economical and readily available, may be useful as an additional probe for studying the functions of serine/threonine protein phosphatases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.0968 mL 25.4842 mL 50.9684 mL 101.9368 mL 127.421 mL
    5 mM 1.0194 mL 5.0968 mL 10.1937 mL 20.3874 mL 25.4842 mL
    10 mM 0.5097 mL 2.5484 mL 5.0968 mL 10.1937 mL 12.7421 mL
    50 mM 0.1019 mL 0.5097 mL 1.0194 mL 2.0387 mL 2.5484 mL
    100 mM 0.051 mL 0.2548 mL 0.5097 mL 1.0194 mL 1.2742 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    斑蝥素; Cantharidin CFN99790 56-25-7 C10H12O4 = 196.20 20mg QQ客服:3257982914
    去甲斑蝥素; Norcantharidin CFN99791 5442-12-6 C8H8O4 = 168.15 20mg QQ客服:3257982914
    (1S)-3-(2-羟基乙基)-2-环戊烯-1,2-二甲醇; Cerberidol CFN99375 126594-64-7 C9H16O3 = 172.2 5mg QQ客服:3257982914
    白头翁素; Anemonine CFN90524 508-44-1 C10H8O4 = 192.17 5mg QQ客服:1148253675
    2,2,5,5-四甲基环己烷-1,4-二酮; 2,2,5,5-Tetramethylcyclohexane-1,4-dione CFN97430 86838-54-2 C10H16O2 = 168.2 5mg QQ客服:215959384

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