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  • 白头翁素

    Anemonine

    白头翁素
    产品编号 CFN90524
    CAS编号 508-44-1
    分子式 = 分子量 C10H8O4 = 192.17
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Monoterpenoids
    植物来源 The herbs of Pulsatilla chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    白头翁素 CFN90524 508-44-1 1mg QQ客服:2056216494
    白头翁素 CFN90524 508-44-1 5mg QQ客服:2056216494
    白头翁素 CFN90524 508-44-1 10mg QQ客服:2056216494
    白头翁素 CFN90524 508-44-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Otago (New Zealand)
  • Copenhagen University (Denmark)
  • Korea Food Research Institute(KFRI) (Korea)
  • Medizinische Universit?t Wien (Austria)
  • St. Jude Children Research Hospital (USA)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Periyar University (India)
  • Yale University (USA)
  • Pennsylvania State University (USA)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Heidelberg University (Germany)
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  • Charles University in Prague (Czech Republic)
  • Chulalongkorn University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean J. Medicinal Crop Sci.2021, 29(1):45-50.
  • Agronomy2020, 10(10),1489
  • Nutr Cancer.2023, 75(1):376-387.
  • J Ginseng Res.2022, 46(1):104-114.
  • Int J Biol Macromol.2019, 126:653-661
  • J.Pharm. & Biome. Anal.2023, 2: 100018.
  • Saf Health Work.2019, 10(2):196-204
  • Biomedicines.2021, 9(8):954.
  • Biomed Pharmacother.2019, 116:108987
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Sci Rep. 2018, 462(8)
  • Nutr Cancer.2022, 1-13.
  • Mutlu Yanic S, Ates EG. JOTCSA.2023, 10(4);893-902.
  • J Asian Nat Prod Res.2019, 5:1-17
  • Oncotarget.2017, 9(3):4161-4172
  • Front Pharmacol.2020, 11:566490.
  • Rev. Chim.2020, 71(3),558-564
  • BMC Plant Biol.2022, 22(1):128.
  • International Food Research Journal2018, 25(6):2560-2571
  • Nutr Res Pract.2023, 17(4):670-681.
  • Mol Pharmacol.2021, 99(2):163-174.
  • Plant Cell Physiol.2018, 59(1):128-141
  • LWT2020, 110397
  • ...
  • 生物活性
    Description: Anemonin, a naturally occurring selective iNOS inhibitor, it has potential anti-inflammatory effect; it is also a potent protective molecule for osteoarthritis, it delays osteoarthritis progression by suppressing ECM loss and chondrocyte hypertrophy partially by suppressing IL-1β/NF-κB pathway activation. Anemonin can alleviate nerve injury after cerebral ischemia and reperfusion (i/r) in rats by improving antioxidant activities and inhibiting apoptosis pathway. Anemonin inhibits melanin synthesis by inhibiting the transcription of the genes encoding MITF, TYR, TRP1, and TRP2.
    Targets: NOS | IL Receptor | NF-kB | MMP(e.g.TIMP) | MITF | TYR | TRP
    In vitro:
    J Dermatol Sci. 2008 Feb;49(2):115-23.
    Anemonin is a natural bioactive compound that can regulate tyrosinase-related proteins and mRNA in human melanocytes.[Pubmed: 17766092 ]
    Melanin is the pigment responsible for skin color. Melanin synthesis occurs with the participation of the tyrosinase (TYR) family of proteins including TYR, tyrosinase-related protein 1 (TRP1), and tyrosinase-related protein 2(TRP2/DCT). The effect of a newly isolated natural compound that inhibits hyperpigmentation on the regulation of the TYR family of proteins was examined.
    METHODS AND RESULTS:
    The natural compound, anemonin, was isolated from Clematis crassifolia Benth and was used to inhibit cellular TYR activity; it was found to have a low cytotoxicity (cell viability > 80%) in human melanocytes. In human melanocytes, anemonin showed both time- and dose-dependent inhibition (IC(50) 43.5 microM) of TYR. Western blot analysis and immunocytochemical staining revealed that expression of TYR, TRP1, and TRP2 was decreased in anemonin-treated melanocytes. Additionally, reverse transcription and quantitative real-time polymerase chain reaction analyses revealed that expression of mRNAs for MITF, TYR, TYRP1, and TYRP2 was also suppressed by anemonin.
    CONCLUSIONS:
    The natural compound, anemonin, an active compound of C. crassifolia, inhibits pigmentation synthesis in human melanocytes. Anemonin inhibits melanin synthesis by inhibiting the transcription of the genes encoding MITF, TYR, TRP1, and TRP2. This natural compound may be a candidate for cosmetic use.
    J Ethnopharmacol. 2008 Mar 28;116(3):518-27.
    Anemonin, from Clematis crassifolia, potent and selective inducible nitric oxide synthase inhibitor[Pubmed: 18281171 ]
    The aim of this study was to examine the anti-inflammatory effects of aerial part of Clematis crassifolia Benth. (Ranunculaceae) based on an iNOS inhibition in lipopolysaccharide (LPS) activated macrophages.
    METHODS AND RESULTS:
    Bioassay-guided fractionation and purification led to the isolation of ibotanolide B (1), calceolarioside B (2), trans-caffeic acid (3), anemonin (Anemonine,4) and 3',4',5,7-tetrahydroxy-6-C-glucopyranosylflavone (5). Their structures were elucidated on the basis of spectroscopic analysis. All these compounds inhibited NO production, detected as nitrite, in activated macrophages except 5. Among them, anemonin (Anemonine,4) was the most potent. Analyses of reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting revealed that it decreased the expression of iNOS mRNA and protein in activated RAW 264.7 cells. In isolated rat thoracic aortic rings, anemonin(Anemonine) prevented the vascular hyporeactivity to phenylephrine induced by LPS whereas it did not affect acetylcholine-induced endothelial NO-dependent relaxation, an index of endothelial NOS (eNOS) activity.
    CONCLUSIONS:
    These results indicated that the potential anti-inflammatory effect of anemonin(Anemonine), the naturally occurring selective iNOS inhibitor, may provide a rationale for the medical use of Clematis crassifolia.
    In vivo:
    J Mol Neurosci. 2014 Jun;53(2):271-9.
    Anemonin alleviates nerve injury after cerebral ischemia and reperfusion (i/r) in rats by improving antioxidant activities and inhibiting apoptosis pathway.[Pubmed: 24443273 ]
    In the present study, we aimed at evaluating the potential neuroprotective effect and the underlying mechanism of anemonin against cerebral ischemia and reperfusion (I/R) injury.
    METHODS AND RESULTS:
    Anemonin was administered to rats by the intraperitoneally (i.p.) route once daily for 7 days before middle cerebral artery occlusion (MCAO). Focal cerebral ischemia was induced by 90 min of MCAO followed by 24 h of reperfusion. After that, animals were sacrificed by decapitation, brain was removed, and various biochemical estimations, neurological status, and assessment of cerebral infarct size were carried out. MCAO followed by 24 h of reperfusion caused a significant increase in infarct size, neurological deficit score, malondialdehyde (MDA) content, reactive oxygen species (ROS) level, and DNA fragmentation, as well as a decrease in the activities of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), and Na(+), K(+)-ATPase in the brain. Furthermore, elevated Bax expression, increased caspase-3 cleavage, and decreased Bcl-2 expression were observed in nontreated rats in response to focal cerebral I/R injury. However, pretreatment with anemonin significantly reversed these levels of biochemical parameters, reduced cerebral infarct size, and improved the neurologic score in cerebral ischemic animals. Additionally, a wide distribution of anemonin in plasma and brain tissues and the brain-to-plasma partition coefficient (Ri) ratio of 0.7 at 90 min indicated that this compound could penetrate the blood-brain barrier (BBB).
    CONCLUSIONS:
    These results showed that pretreatment with anemonin provided a significant protection against cerebral I/R injury in rats by, at least in part, its antioxidant action and consequent inhibition of apoptosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.2037 mL 26.0186 mL 52.0373 mL 104.0745 mL 130.0931 mL
    5 mM 1.0407 mL 5.2037 mL 10.4075 mL 20.8149 mL 26.0186 mL
    10 mM 0.5204 mL 2.6019 mL 5.2037 mL 10.4075 mL 13.0093 mL
    50 mM 0.1041 mL 0.5204 mL 1.0407 mL 2.0815 mL 2.6019 mL
    100 mM 0.052 mL 0.2602 mL 0.5204 mL 1.0407 mL 1.3009 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    斑蝥素; Cantharidin CFN99790 56-25-7 C10H12O4 = 196.20 20mg QQ客服:2159513211
    去甲斑蝥素; Norcantharidin CFN99791 5442-12-6 C8H8O4 = 168.15 20mg QQ客服:215959384
    (1S)-3-(2-羟基乙基)-2-环戊烯-1,2-二甲醇; Cerberidol CFN99375 126594-64-7 C9H16O3 = 172.2 5mg QQ客服:2159513211
    白头翁素; Anemonine CFN90524 508-44-1 C10H8O4 = 192.17 5mg QQ客服:1457312923
    2,2,5,5-四甲基环己烷-1,4-二酮; 2,2,5,5-Tetramethylcyclohexane-1,4-dione CFN97430 86838-54-2 C10H16O2 = 168.2 5mg QQ客服:1413575084

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