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  • 伪异沙蟾毒精

    Bufarenogin

    伪异沙蟾毒精
    产品编号 CFN90151
    CAS编号 17008-65-0
    分子式 = 分子量 C24H32O6 = 416.51
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The glandular body of Bufo bufo gargarizans Cantor
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    伪异沙蟾毒精 CFN90151 17008-65-0 1mg QQ客服:2159513211
    伪异沙蟾毒精 CFN90151 17008-65-0 5mg QQ客服:2159513211
    伪异沙蟾毒精 CFN90151 17008-65-0 10mg QQ客服:2159513211
    伪异沙蟾毒精 CFN90151 17008-65-0 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Amity University (India)
  • The Institute of Cancer Research (United Kingdom)
  • Universite Libre de Bruxelles (Belgium)
  • Cornell University (USA)
  • Aveiro University (Portugal)
  • Korea Institute of Oriental Medicine (Korea)
  • Sanford Burnham Medical Research Institute (USA)
  • Copenhagen University (Denmark)
  • Weizmann Institute of Science (Israel)
  • Chinese University of Hong Kong (China)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Utrecht University (Netherlands)
  • Ain Shams University (Egypt)
  • Universidad Industrial de Santander (Colombia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Adaptive Medicine 2020, 12(1): 4-10
  • Tissue Cell.2022, 75:101728.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • iScience.2023, 26(9):107602.
  • BMC Microbiol.2019, 19(1):78
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Molecules.2020, 25(15):3353.
  • Int J Mol Sci.2021, 22(16):8641.
  • J. Food Composition and Anal.2022, V 109:104482.
  • J Am Soc Mass Spectrom.2021, 32(5):1205-1214.
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Onco Targets Ther.2017, 10:3467-3474
  • J Appl Microbiol.2022, 132(2):949-963.
  • Nutr Res Pract.2020, 14(3):203-217.
  • Pharmacological Reports2020, 1-9
  • Molecules.2018, 23(10):E2638
  • Life (Basel).2021, 11(12):1399.
  • Int Immunopharmacol.2023, 123:110572.
  • Biosci Rep.2020, 40(8):BSR20201219.
  • Oxid Med Cell Longev.2022, 2022:9139338.
  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • JOTCSA.2023, 10(4); 893-902.
  • ...
  • 生物活性
    Description: ψ-Bufarenogin has inhibitory activity on human kidney Na(+)/K(+)-ATPase, it has cytotoxicity against HepG2 and MCF-7 human cancer cells.ψ-Bufarenogin exhibits potent therapeutic effect in xenografted human hepatoma without notable side effects,at least partially,via inhibiting receptor tyrosine kinases-regulated signaling.
    Targets: MEK | ERK | PI3K | Akt | Raf | EGFR | Sodium Channel | ATPase | Potassium Channel
    In vitro:
    Toxicon. 2016 Feb;110:27-34.
    Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na(+)/K(+)-ATPase activity.[Pubmed: 26615828 ]
    Parotoid gland secretions of toad species are a vast reservoir of bioactive molecules with a wide range of biological properties.
    METHODS AND RESULTS:
    Herein, for the first time, it is described the isolation by preparative reversed-phase HPLC and the structure elucidation by NMR spectroscopy and/or mass spectrometry of nine major bufadienolides from parotoid gland secretions of the Cuban endemic toad Peltophryne fustiger: ψ-Bufarenogin, gamabufotalin, Bufarenogin, arenobufagin, 3-(N-suberoylargininyl) marinobufagin, bufotalinin, telocinobufagin, marinobufagin and bufalin. In addition, the secretion was analyzed by UPLC-MS/MS which also allowed the identification of azelayl arginine. The effect of arenobufagin, bufalin and ψ-Bufarenogin on Na(+)/K(+)-ATPase activity in a human kidney preparation was evaluated. These bufadienolides fully inhibited the Na(+)/K(+)-ATPase in a concentration-dependent manner, although arenobufagin (IC50 = 28.3 nM) and bufalin (IC50 = 28.7 nM) were 100 times more potent than ψ-Bufarenogin (IC50 = 3020 nM).
    CONCLUSIONS:
    These results provided evidence about the importance of the hydroxylation at position C-14 in the bufadienolide skeleton for the inhibitory activity on the Na(+)/K(+)-ATPase.
    Biocatalysis, 2011, 29(2-3):96-101.
    Biotransformation of arenobufagin and cinobufotalin by Alternaria alternata.[Reference: WebLink]
    The biotransformation of arenobufagin (1) and cinobufotalin (2), isolated from the natural medicine Chan Su, by Alternaria alternata AS 3.4578 was carried out.
    METHODS AND RESULTS:
    Incubation of 1 and 2 afforded six metabolites: 3-oxo-arenobufagin (1a), ψ-Bufarenogin (1b), 3-oxo-ψ-Bufarenogin (1c), 3-oxo-Δ4-derivative of cinobufotalin (2a), 3-oxo-cinobufotalin (2b) and 12β-hydroxycinobufotalin (2c). Among them, metabolites 1a, 1c and 2c are new compounds and their structures were characterized on the basis of their spectroscopic data (NMR, MS and IR).
    CONCLUSIONS:
    Compounds 1, 2, 1b, 2a and 2b were evaluated for their cytotoxicity against HepG2 and MCF-7 human cancer cells, and all of them showed significant inhibitory activities.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4009 mL 12.0045 mL 24.009 mL 48.0181 mL 60.0226 mL
    5 mM 0.4802 mL 2.4009 mL 4.8018 mL 9.6036 mL 12.0045 mL
    10 mM 0.2401 mL 1.2005 mL 2.4009 mL 4.8018 mL 6.0023 mL
    50 mM 0.048 mL 0.2401 mL 0.4802 mL 0.9604 mL 1.2005 mL
    100 mM 0.024 mL 0.12 mL 0.2401 mL 0.4802 mL 0.6002 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    沙蟾毒精 3-辛二酸半酯; Arenobufagin 3-hemisuberate CFN90957 30219-16-0 C32H44O9 = 572.69 5mg QQ客服:1413575084
    原海葱甙A; Proscillaridin A CFN70368 466-06-8 C30H42O8 = 530.7 5mg QQ客服:2056216494
    19-羟基蟾毒灵; 19-Hydroxybufalin CFN91020 39844-86-5 C24H34O5 = 402.52 5mg QQ客服:1457312923
    远华蟾蜍精; Telocinobufagin CFN90213 472-26-4 C24H34O5 = 402.52 20mg QQ客服:1413575084
    嚏根草醇; Hellebrigenol CFN91021 508-79-2 C24H34O6 = 418.52 5mg QQ客服:1457312923
    日本蟾蜍毒苷元; Gamabufotalin CFN90212 465-11-2 C24H34O5 = 402.52 20mg QQ客服:1413575084
    沙蟾毒精; Arenobufagin CFN98578 464-74-4 C24H32O6 = 416.51 20mg QQ客服:1413575084
    伪异沙蟾毒精; Bufarenogin CFN90151 17008-65-0 C24H32O6 = 416.51 5mg QQ客服:3257982914
    伪异沙蟾毒精; Pseudobufarenogin CFN91017 17008-69-4 C24H32O6 = 416.51 10mg QQ客服:1457312923
    蟾毒它灵, 蟾蜍他灵; Bufotaline CFN98545 471-95-4 C26H36O6 = 444.56 20mg QQ客服:2159513211

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