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  • 日本蟾蜍毒苷元

    Gamabufotalin

    日本蟾蜍毒苷元
    产品编号 CFN90212
    CAS编号 465-11-2
    分子式 = 分子量 C24H34O5 = 402.52
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The glandular body of Bufo bufo gargarizans Cantor.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    日本蟾蜍毒苷元 CFN90212 465-11-2 10mg QQ客服:1457312923
    日本蟾蜍毒苷元 CFN90212 465-11-2 20mg QQ客服:1457312923
    日本蟾蜍毒苷元 CFN90212 465-11-2 50mg QQ客服:1457312923
    日本蟾蜍毒苷元 CFN90212 465-11-2 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Celltrion Chemical Research Institute (Korea)
  • Wageningen University (Netherlands)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Amsterdam (Netherlands)
  • Hamdard University (India)
  • Universitas Airlangga (Indonesia)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • University of Indonesia (Indonesia)
  • Kamphaengphet Rajabhat University (Thailand)
  • Pennsylvania State University (USA)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Agricultural Research Organization (ARO) (Israel)
  • CSIRO - Agriculture Flagship (Australia)
  • Gyeongsang National University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. Food Composition and Anal.2022, V 109:104482.
  • J Food Biochem.2020, 44(6):e13198.
  • Sci Rep.2018, 8(1):12970
  • Applied Biological Chemistry2022, 65(77).
  • ACS Omega.2022, 7(44):40009-40020.
  • Sci Rep.2018, 8(1)
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Antiviral Res.2013, 98(3):386-93
  • Evid Based Complement Alternat Med.2021, 8855980.
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Front Cell Dev Biol.2021, 9:764263.
  • Nutrients.2017, 10(1)
  • Neurotox Res.2022, 40(6):1937-1947.
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • Analytical sci. & Tech2020, 33(5):224-231
  • Food Sci Nutr.2023, 00:1-10.
  • Journal of Analytical Chemistry2017, 854-861
  • Plant Foods Hum Nutr.2020, 10.1007
  • Food Funct.2022, 13(13):6923-6933.
  • Environ Toxicol.2020, doi: 10.1002
  • Molecules.2020, 25(3):734
  • Chem Biol Interact.2020, 328:109200.
  • 2023, 24(6):5769.Int J Mol Sci.
  • ...
  • 生物活性
    Description: Gamabufotalin has been used for treatment of COX-2-mediated diseases and cancer therapy, it triggers c-Myc degradation via induction of WWP2 in multiple myeloma(MM) cells. Gamabufotalin strongly inhibit cancer cell growth and inflammatory response, it inhibits angiogenesis by inhibiting the activation of VEGFR-2 signaling pathways and could be a potential candidate in angiogenesis-related disease therapy.
    Targets: COX | p65 | NF-kB | IkB | VEGFR | c-Myc | JNK | IKK
    In vitro:
    Oncotarget. 2016 Jan 19;7(3):3533-47.
    Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway.[Pubmed: 26657289 ]
    Gamabufotalin (CS-6), a main active compound isolated from Chinese medicine Chansu, has been shown to strongly inhibit cancer cell growth and inflammatory response. However, its effects on angiogenesis have not been known yet.
    METHODS AND RESULTS:
    Here, we sought to determine the biological effects of CS-6 on signaling mechanisms during angiogenesis. Our present results fully demonstrate that CS-6 could significantly inhibit VEGF triggered HUVECs proliferation, migration, invasion and tubulogenesis in vitro and blocked vascularization in Matrigel plugs impregnated in C57/BL6 mice as well as reduced vessel density in human lung tumor xenograft implanted in nude mice. Computer simulations revealed that CS-6 interacted with the ATP-binding sites of VEGFR-2 using molecular docking. Furthermore, western blot analysis indicated that CS-6 inhibited VEGF-induced phosphorylation of VEGFR-2 kinase and suppressed the activity of VEGFR-2-mediated signaling cascades.
    CONCLUSIONS:
    Therefore, our studies demonstrated that CS-6 inhibited angiogenesis by inhibiting the activation of VEGFR-2 signaling pathways and CS-6 could be a potential candidate in angiogenesis-related disease therapy.
    Oncotarget. 2016 Mar 29;7(13):15725-37.
    Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells.[Pubmed: 26894970 ]
    Deciding appropriate therapy for multiple myeloma (MM) is challenging because of the occurrence of multiple chromosomal changes and the fatal nature of the disease.
    METHODS AND RESULTS:
    In the current study, gamabufotalin (GBT) was isolated from toad venom, and its tumor-specific cytotoxicity was investigated in human MM cells. We found GBT inhibited cell growth and induced apoptosis with the IC50 values <50 nM. Mechanistic studies using functional approaches identified GBT as an inhibitor of c-Myc. Further analysis showed that GBT especially evoked the ubiquitination and degradation of c-Myc protein, thereby globally repressing the expression of c-Myc target genes. GBT treatment inhibited ERK and AKT signals, while stimulating the activation of JNK cascade. An E3 ubiquitin-protein ligase, WWP2, was upregulated following JNK activation and played an important role in c-Myc ubiquitination and degradation through direct protein-protein interaction. The antitumor effect of GBT was validated in a xenograft mouse model and the suppression of MM-induced osteolysis was verified in a SCID-hu model in vivo.
    CONCLUSIONS:
    Taken together, our study identified the potential of GBT as a promising therapeutic agent in the treatment of MM.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4843 mL 12.4217 mL 24.8435 mL 49.687 mL 62.1087 mL
    5 mM 0.4969 mL 2.4843 mL 4.9687 mL 9.9374 mL 12.4217 mL
    10 mM 0.2484 mL 1.2422 mL 2.4843 mL 4.9687 mL 6.2109 mL
    50 mM 0.0497 mL 0.2484 mL 0.4969 mL 0.9937 mL 1.2422 mL
    100 mM 0.0248 mL 0.1242 mL 0.2484 mL 0.4969 mL 0.6211 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去乙酰华蟾毒它灵; Desacetylcinobufotalin CFN93073 4099-30-3 C24H32O6 = 416.51 5mg QQ客服:3257982914
    华蟾素; Cinobufotalin CFN90137 1108-68-5 C26H34O7 = 458.54 20mg QQ客服:2159513211
    华蟾毒精醇; Cinobufaginol CFN91051 6691-83-4 C26H34O7 = 458.55 5mg QQ客服:1457312923
    19-氧代华蟾毒它灵; 19-Oxocinobufotalin CFN91016 24512-60-5 C26H32O8 = 472.53 5mg QQ客服:3257982914
    沙蟾毒精 3-辛二酸半酯; Arenobufagin 3-hemisuberate CFN90957 30219-16-0 C32H44O9 = 572.69 5mg QQ客服:3257982914
    原海葱甙A; Proscillaridin A CFN70368 466-06-8 C30H42O8 = 530.7 5mg QQ客服:3257982914
    19-羟基蟾毒灵; 19-Hydroxybufalin CFN91020 39844-86-5 C24H34O5 = 402.52 5mg QQ客服:1413575084
    远华蟾蜍精; Telocinobufagin CFN90213 472-26-4 C24H34O5 = 402.52 20mg QQ客服:215959384
    嚏根草醇; Hellebrigenol CFN91021 508-79-2 C24H34O6 = 418.52 5mg QQ客服:2056216494
    日本蟾蜍毒苷元; Gamabufotalin CFN90212 465-11-2 C24H34O5 = 402.52 20mg QQ客服:215959384

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