| Description: |
Blumeatin has antioxidant properties, free radical scavenging activity,and has xanthine oxidase (XO) inhibitory activity. Blumeatin can protect liver against injury induced by CCl4 and TAA, it can inhibit the increase of serum alanine aminotransferase (AAT) and liver triglyceride and increased serum triglyceride, beta-lipoprotein, and liver glycogen content in CCl4-intoxicated rats, and can shorten the pentobarbital sleeping time in CCl4-intoxicated mice. Blumeatin can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells, also can enhance the accumulation of lipid droplets and induced upregulation of the expression of the adipocyte-specific genes aP2 and GLUT4. |
| In vitro: |
| Food Chem., 2004, 88(2):243-52. | | Free radical-scavenging activity of organic extracts and of pure flavonoids of Blumea balsamifera DC leaves.[Reference: WebLink] | Phytochemical investigation on the leaves of Blumea balsamifera DC resulted in the isolation of 11 flavonoids. Their chemical structures were elucidated by means of elemental analyses and different spectroscopic methods, such as UV, IR, NMR and MS.
METHODS AND RESULTS:
The free radical scavenging activity of organic extracts of B. balsamifera DC leaves and that of pure flavonoids isolated from the leaves was evaluated using 1,1-diphenyl-2-picrylhydrazyl radical. A dose response curve was plotted for determining SC50 values (the concentrations required to inhibit radical formation by 50%). The antioxidant activities of crude extracts decreased in the order: methanol extract > chloroform extract > pet-ether extract. The antioxidant activities of all compounds tested decreased in the order: quercetin > rhamnetin > luteolin > luteolin-7-methylether > L-ascorbic acid > Blumeatin > butylated hydroxyanisole > 5,7,3',5'-tetrahydroxyflavanone > tamarixetin > butylated hydroxytoluene > alpha-tocopherol > dihydroquercetin-4'-methylether > dihydroquercetin-7,4'-dimethylether.
CONCLUSIONS:
This result indicates that flavonoid contents of different solvent extracts of B. balsamifera DC leaves were responsible for their antioxidant properties. | | J Nat Prod. 2012 Apr 27;75(4):699-706. | | Isoprenylated flavonoid and adipogenesis-promoting constituents of Dodonaea viscosa.[Pubmed: 22512738 ] | Ten new isoprenylated flavonol derivatives, dodoviscins A-J (1-10), and seven known compounds (11-17) were isolated from the aerial parts of Dodonaea viscosa.
METHODS AND RESULTS:
Compounds 1, 2, 4, 5, 7-9, 5,7,4'-trihydroxy-3',5'-bis(3-methyl-2-buten-1-yl)-3-methoxyflavone (11), 5,7,4'-trihydroxy-3',5'-bis(3-methyl-2-buten-1-yl)-3,6-dimethoxyflavone (12), 5,7,4'-trihydroxy-3'-(4-hydroxy-3-methylbutyl)-5'-(3-methyl-2-buten-1-yl)-3,6-dimethyoxyflavone (13), sakuranetin (14), and Blumeatin (15) promoted adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells. Compounds 1, 13, and 15 also enhanced the accumulation of lipid droplets and induced upregulation of the expression of the adipocyte-specific genes aP2 and GLUT4. |
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| In vivo: |
| Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):376-8. | | Protective action of blumeatin against experimental liver injuries.[Pubmed: 8249641] | Blumeatin (Blu, 5,3',5'-trihydroxy-7-methoxy-dihydro-flavone) was first isolated from Blumea balsamifera DC by Department of Chemistry, Sunyatsen University of China.
METHODS AND RESULTS:
Blu ip inhibited the increase of serum alanine aminotransferase (AAT) and liver triglyceride and increased serum triglyceride, beta-lipoprotein, and liver glycogen content in CCl4-intoxicated rats. Histological lesions of liver were less severe than those of hepatic injury control. Blu ip 0.65 and 3.25 mg.kg-1 inhibited the increase of serum AAT and hepatic TG in thioacetamide (TAA)-intoxicated mice. Blu ip shortened the pentobarbital sleeping time in CCl4-intoxicated mice.
CONCLUSIONS:
It suggested that Blu could protect liver against injury induced by CCl4 and TAA. |
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