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  • 3',5,5',7-四羟基黄烷酮

    3',5,5',7-Tetrahydroxyflavanone

    3',5,5',7-四羟基黄烷酮
    产品编号 CFN99673
    CAS编号 160436-10-2
    分子式 = 分子量 C15H12O6 = 288.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Ilex centrochinensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3',5,5',7-四羟基黄烷酮 CFN99673 160436-10-2 1mg QQ客服:1413575084
    3',5,5',7-四羟基黄烷酮 CFN99673 160436-10-2 5mg QQ客服:1413575084
    3',5,5',7-四羟基黄烷酮 CFN99673 160436-10-2 10mg QQ客服:1413575084
    3',5,5',7-四羟基黄烷酮 CFN99673 160436-10-2 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Wollongong (Australia)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Charles Sturt University (Denmark)
  • University of Cincinnati (USA)
  • University of Malaya (Malaysia)
  • Almansora University (Egypt)
  • Universitas islam negeri Jakarta (Indonesia)
  • Universite Libre de Bruxelles (Belgium)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of Stirling (United Kingdom)
  • University of Illinois (USA)
  • Universidade Católica Portuguesa (Portugal)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Max-Planck-Insitut (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci Rep.2020, 10:4495(2020)
  • Molecules.2019, 24(6):E1155
  • Braz J Biol.2023, 82:e266573.
  • PLoS One.2018, 13(3):e0193386
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • Vietnam Journal of Food Control.2022, 5(2): 115-128.
  • J Pharm Biomed Anal.2022, 207:114398.
  • J Nat Prod.2023, 86(2):264-275.
  • Chem Biol Interact.2020, 328:109200.
  • Enzyme Microb Technol.2022, 153:109941.
  • Vietnam J. Chemistry2022, 60(2):211-222
  • South African J of Botany2020, 135:50-57
  • Biomed Pharmacother.2022, 145:112474.
  • Br J Pharmacol.2020, 10.1111
  • Appl. Sci.2020, 10(23), 8729
  • Int J Mol Sci.2019, 20(14):E3538
  • Int J Mol Sci.2022, 23(21):13406.
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Am J Chin Med.2016, 44(8):1719-1735
  • Biochem Biophys Res Commun.2021, 534:802-807.
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • J Pharmaceutical Research Int.2021, 33(41A):275-284.
  • Arch Toxicol.2017, 91(10):3225-3245
  • ...
  • 生物活性
    Description: 5,7,3',5'-Tetrahydroxyflavanone has anti-inflammatory properties, it can inhibit nitric oxide (NO) production with IC50 values of 18.5 uM, the inhibitory effect is accompanied by dose-dependent decreases in LPS-induced nitric oxide synthase (iNOS) in RAW 264.7 cells. It may have antiviral activity against HIV-1, it has inhibitory effects on HIV-1 reverse transcriptase (RT)-associated RNase H function.
    Targets: HIV | NO | NOS
    In vitro:
    Pathog Dis. 2013 Aug;68(3):116-24.
    Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities.[Pubmed: 23821410 ]
    Among HIV-1 reverse transcriptase (RT)-associated functions, DNA polymerase and Ribonuclease H (RNase H) are both essential for HIV replication and excellent targets for drug development. While all RT inhibitors approved for therapy target the DNA polymerase activity, there is the pressing need for new RT inhibitors possibly targeting the RNase H function. In the last 20 years, many natural substances have shown antiviral activity against HIV-1, but only a few against the RNase H function.
    METHODS AND RESULTS:
    In this study, we have tested the ethanolic extracts obtained by the Hypericum hircinum L. (Hypericaceae) growing in Sardinia (Italy) on the HIV-1 RT-associated RNase H function and found that they have inhibitory effects. Active extracts were fractionated up to obtain the main components that have been isolated, tested, and identified to be betulinic acid, shikimic acid, chlorogenic acid, quercetin, 5,7,3',5'-tetrahydroxyflavanone(3',5,5',7-Tetrahydroxyflavanone), and 5,7,3',5'-tetrahydroxyflavanone 7-O-glucoside. Betulinic acid and 5,7,3',5'-tetrahydroxyflavanone 7-O-glucoside were active on both RT-associated activities, and betulinic acid was also active on HIV-1 mutant RTs resistant to efavirenz.
    CONCLUSIONS:
    Overall, our results suggest that some of these compounds inhibit the HIV-1 RT binding to an allosteric site previously described for other natural compounds and are potential leads for further drug development of a single molecules having dual inhibitory activity.
    Nat Prod Commun. 2015 Mar;10(3):383-5.
    Anti-inflammatory compounds from Ampelopsis cantoniensis.[Pubmed: 25924510]
    Many natural products have been shown to have an inhibitory effect on nitric oxide (NO), and are used as chemotherapy agents for inflammation disease. The current study was designed to evaluate the anti-inflammatory activity of chemical components from the leaves of Ampelopsis cantoniensis.
    METHODS AND RESULTS:
    Sixteen compounds (1-16) were isolated and identified. Phloretin (5) and 5,7,3',5'-tetrahydroxyflavanone (3',5,5',7-Tetrahydroxyflavanone,16) inhibited nitric oxide (NO) production with IC50 values of 5.2, and 18.5 μM, respectively. The inhibitory effect of compounds 5 and 16 were accompanied by dose-dependent decreases in LPS-induced nitric oxide synthase (iNOS) in RAW 264.7 cells, respectively. This study investigated the significant anti-inflammatory properties of isolated compounds from the leaves of A. cantoniensis for the first time.
    CONCLUSIONS:
    The findings demonstrate that A. cantoniensis could be used beneficially in the treatment of inflammation disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4686 mL 17.343 mL 34.6861 mL 69.3722 mL 86.7152 mL
    5 mM 0.6937 mL 3.4686 mL 6.9372 mL 13.8744 mL 17.343 mL
    10 mM 0.3469 mL 1.7343 mL 3.4686 mL 6.9372 mL 8.6715 mL
    50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.3874 mL 1.7343 mL
    100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6937 mL 0.8672 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7,2',6'-四羟基黄烷酮; 2',5,6',7-Tetrahydroxyflavanone CFN97285 80604-16-6 C15H12O6 = 288.3 5mg QQ客服:1413575084
    2',5,6',7-四乙酰氧基黄烷酮; 2',5,6',7-Tetraacetoxyflavanone CFN97286 80604-17-7 C23H20O10 = 456.4 5mg QQ客服:2159513211
    草大戟素; Steppogenin CFN98949 56486-94-3 C15H12O6 = 288.3 5mg QQ客服:2056216494
    3',5,5',7-四羟基黄烷酮; 3',5,5',7-Tetrahydroxyflavanone CFN99673 160436-10-2 C15H12O6 = 288.3 5mg QQ客服:1413575084
    艾纳香素; Blumeatin CFN99278 118024-26-3 C16H14O6 = 302.3 5mg QQ客服:215959384
    刺槐双氢黄酮; Robtin CFN98672 4382-34-7 C15H12O6 = 288.3 5mg QQ客服:2056216494
    车前子苷; Plantagoside CFN91894 78708-33-5 C21H22O12 = 466.39 5mg QQ客服:3257982914
    3',4',5',5,7-五甲氧基二氢黄酮; 3',4',5',5,7-Pentamethoxyflavanone CFN95414 479672-30-5 C20H22O7 = 374.4 20mg QQ客服:3257982914
    5,7,3'-三羟基-6,4',5'-三甲氧基黄烷酮; 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavanone CFN98393 310888-07-4 C18H18O8 = 362.3 5mg QQ客服:2159513211
    5,6,7,3',4',5'-六甲氧基二氢黄酮; 5,6,7,3',4',5'-Hexamethoxyflavanone CFN95376 74064-17-8 C21H24O8 = 404.4 10mg QQ客服:3257982914

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