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  • 甜没药萜醇氧化物A

    Bisabolol oxide A

    甜没药萜醇氧化物A
    产品编号 CFN91107
    CAS编号 22567-36-8
    分子式 = 分子量 C15H26O2 = 238.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Matricaria chamomilla
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甜没药萜醇氧化物A CFN91107 22567-36-8 1mg QQ客服:1413575084
    甜没药萜醇氧化物A CFN91107 22567-36-8 5mg QQ客服:1413575084
    甜没药萜醇氧化物A CFN91107 22567-36-8 10mg QQ客服:1413575084
    甜没药萜醇氧化物A CFN91107 22567-36-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • Eur J Pharmacol.2023, 960:176121.
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  • ...
  • 生物活性
    Description: Bisabololoxide A induces apoptosis in rat thymocytes.
    In vitro:
    Arch Toxicol. 2010 Jan;84(1):45-52.
    Bisabololoxide A, one of the main constituents in German chamomile extract, induces apoptosis in rat thymocytes.[Pubmed: 19834689 ]
    German chamomile (Matricaria recutita L.), one of the popular ingredients in herbal teas, has been traditionally used for medicinal purposes. Bisabolol oxide A (BSBO) is one of the main constituents in this herb. BSBO is supposed to be principle in some bioactivities of German chamomile such as anti-inflammatory, gastrointestinal, and antipruritic actions. Although the use of German chamomile has spread, the information related to toxicity of BSBO is very limited.
    METHODS AND RESULTS:
    In present study, the cytotoxic effect of micromolar BSBO was cytometrically examined on rat thymocytes by using appropriate fluorescent dyes. When the cells were incubated with BSBO for 24 h, BSBO at concentrations of 30 microM or more significantly increased populations of dead cells, shrunken cells, and cells with phosphatidylserine exposed on membrane surface. Both cell shrinkage and externalization of membrane phosphatidylserine are general features in an early stage of apoptosis. In addition, BSBO significantly increased population of cells containing hypodiploid DNA, and the increase was completely attenuated by Z-VAD-FMK, a pan-inhibitor for caspases, indicating an involvement of caspase activation.
    CONCLUSIONS:
    Thus, it is likely that the type of cell death induced by BSBO is apoptosis. The significant changes in cellular parameters of rat thymocytes by BSBO were not observed when the concentration was 10 microM or less. Furthermore, the short incubation (3 h) of cells even with 30-100 microM BSBO did not significantly affect the cells. Therefore, it may be suggested that BSBO is practically safe when German chamomile is conventionally used.
    Phytomedicine. 2011 Mar 15;18(5):362-5.
    Cytotoxic action of bisabololoxide A of German chamomile on human leukemia K562 cells in combination with 5-fluorouracil[Pubmed: 20863677 ]
    German chamomile (Matricaria recutita L.) is a popular ingredient in herbal teas. In previous study, micromolar bisabololoxide A, one of main constituents in German chamomile, exerted cytotoxic action on rat thymocyte, a normal non-proliferative cell. This result prompted us to study the effect of bisabololoxide A on proliferative cancer cells and to seek the possibility of its use with 5-fluorouracil, an anticancer agent.
    METHODS AND RESULTS:
    In this study, the effect of micromolar bisabolol oxide A on human leukemia K562 cells was cytometrically examined. Although the incubation of K562 cells with 10 μM bisabolol oxide A for 72h did not significantly increase the percentage populations of dead cells and shrunken cells, the inhibitory action on the growth was obviously observed. It was not the case for the concentrations of less than 5 μM. The threshold concentration of bisabolol oxide A to exert the cytotoxic action on K562 cells was ascertained to be 5-10 μM. Bisabolol oxide A at 5-10 μM did not exert cytotoxic action on normal non-proliferative cells (rat thymocytes) in our previous study. Since the antiproliferative action of micromolar bisabolol oxide A on cancerous cells was expected to be beneficial to cancer treatment, the modification of antiproliferative action of 5-fluorouracil (3-30 μM) by bisabolol oxide A was studied. The combination of 5-fluorouracil and bisabolol oxide further inhibited the growth of K562 cells although the additive inhibition of growth by bisabolol oxide A became smaller as the concentration of 5-fluorouracil increased.
    CONCLUSIONS:
    Therefore, it is suggested that the simultaneous application of German chamomile containing bisabolol oxide A may reduce the dose of 5-fluorouracil.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1952 mL 20.9758 mL 41.9516 mL 83.9032 mL 104.879 mL
    5 mM 0.839 mL 4.1952 mL 8.3903 mL 16.7806 mL 20.9758 mL
    10 mM 0.4195 mL 2.0976 mL 4.1952 mL 8.3903 mL 10.4879 mL
    50 mM 0.0839 mL 0.4195 mL 0.839 mL 1.6781 mL 2.0976 mL
    100 mM 0.042 mL 0.2098 mL 0.4195 mL 0.839 mL 1.0488 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (2S,3S,4R,2'R)-2-(2'-羟基二十四碳酰氨基)十八烷-1,3,4-三醇; 2-(2'-Hydroxytetracosanoylamino)-octadecane-1,3,4-triol CFN99649 154801-30-6 C42H85NO5 = 684.1 5mg QQ客服:2056216494
    泽泻醇P; Alisol P CFN95662 1005191-19-4 C30H48O7 = 520.7 5mg QQ客服:2056216494
    2,4-二羟基-6-甲基甲酸乙酯; Ethyl orsellinate CFN97773 2524-37-0 C10H12O4 = 196.20 20mg QQ客服:215959384
    6-O-对甲氧基肉桂酰梓醇; 6-O-p-Methoxycinnamoylcatalpol CFN99335 121710-02-9 C25H30O12 = 522.5 5mg QQ客服:2056216494

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