Info: Read More
  • 中药标准品生产商,产品定制服务
  • Kanzonol C

    Kanzonol C

    Kanzonol C
    产品编号 CFN93192
    CAS编号 151135-82-9
    分子式 = 分子量 C25H28O4 = 392.49
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The roots of Glycyrrhiza uralensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Kanzonol C CFN93192 151135-82-9 1mg QQ客服:1457312923
    Kanzonol C CFN93192 151135-82-9 5mg QQ客服:1457312923
    Kanzonol C CFN93192 151135-82-9 10mg QQ客服:1457312923
    Kanzonol C CFN93192 151135-82-9 20mg QQ客服:1457312923
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Kyushu University (Japan)
  • University of Hertfordshire (United Kingdom)
  • University of Helsinki (Finland)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Universidade Federal de Santa Catarina (Brazil)
  • Utah State University (USA)
  • University of Toulouse (France)
  • The Australian National University (Australia)
  • Weizmann Institute of Science (Israel)
  • Anna University (India)
  • Ateneo de Manila University (Philippines)
  • Medizinische Universit?t Wien (Austria)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Foods.2022, 11(12):1708.
  • Food Res Int.2022, 157:111207.
  • Food Res Int.2020, 133:109130.
  • JAOCS2021, 98(7):779-794.
  • J Ethnopharmacol.2019, 241:112025
  • Pharm Biol.2017, 55(1):360-366
  • Life Sci.2021, 286:120019.
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Food Chem.2019, 274:345-350
  • J Korean Med Obes Res.2023, 23:10-7
  • Phytother Res.2022, 35844057.
  • Mol Cells.2018, 41(8):771-780
  • Life (Basel).2022, 12(12):2107.
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • Int J Mol Sci.2022, 23(11):6104.
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Appl. Sci. 2021, 11(22),10569
  • Molecules2022, 27(9):2827.
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Onco Targets Ther.2017, 10:3467-3474
  • FASEB J.2019, 33(8):9685-9694
  • Nutrients2020, 12(3):811.
  • Plant Biotechnology Reports 2021, 15:117-124.
  • ...
  • 生物活性
    Description: Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secretion from brain tumor-derived glioblastoma cells.
    Targets: NO | NF-kB | Tyrosinase | Antifection | MMP | PTP1B
    In vitro:
    Bioorg Med Chem. 2017 Jul 15;25(14):3706-3713.
    Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.[Pubmed: 28522265]
    Licorice shows a variety of pharmacological activities. This work aims to discover bioactive natural products from one botanical source of licorice, Glycyrrhiza inflata. A total of 67 free phenolics were isolated to form a compound library.
    METHODS AND RESULTS:
    Based on the bioactivities of licorice, these compounds were screened using cell- or enzyme-based bioassay methods. A total of 11 compounds exhibited potent cytotoxic activities against three human cancer cell lines (HepG2, SW480 and MCF7), while showed little toxicity on human normal cell lines LO2 and HEK293T. A number of chalcones showed remarkable anti-inflammatory activities. Among them, 2 (licochalcone B, IC50 8.78μM), 10 (licoagrochalcone C, IC50 9.35μM) and 13 (licochalcone E, IC50 9.09μM) exhibited the most potent inhibitory activities on LPS-induced NO production, whereas 1, 8, 10, 12 and 13 (IC50 13.9, 7.27, 2.44, 6.67 and 3.83μM) showed potent inhibitory activities on NF-κB transcription.
    CONCLUSIONS:
    Nine prenylated phenolics were found to be PTP1B inhibitors. Particularly, licoagrochalcone A (4), Kanzonol C (7), 2'-hydroxyisolupalbigenin (35), gancaonin Q (45), glisoflavanone (50) and glabrol (53) showed IC50 values of 0.31-0.97μM. Compounds 24 (semilicoisoflavone B, IC50 0.25μM), 26 (allolicoisoflavone B, IC50 0.80μM) and 64 (glabridin, IC50 0.10μM) showed noticeable tyrosinase inhibitory activities. Most of the above bioactive compounds were reported for the first time.
    J Ethnopharmacol. 2008 Mar 28;116(3):483-9.
    Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae).[Pubmed: 18280679 ]
    The aim of this study was to evaluate the antimicrobial activity of the crude extract of the twigs of Dorstenia barteri (DBT) as well as that of four of the five flavonoids isolated from this extract.
    METHODS AND RESULTS:
    Gram-positive bacteria (six species), Gram-negative bacteria (12 species) and fungi (four species) were used. The agar disc diffusion test was used to determine the sensitivity of the tested samples while the well micro-dilution was used to determine the minimal inhibition concentrations (MIC) and the minimal microbicidal concentration (MMC) of the active samples. The results of the disc diffusion assay showed that DBT, isobavachalcone (1), and Kanzonol C (4) prevented the growth of all the 22 tested microbial species. Other compounds showed selective activity. The inhibitory activity of the most active compounds namely compounds 1 and 4 was noted on 86.4% of the tested microorganisms and that of 4-hydroxylonchocarpin (3) was observed on 72.7%. This lowest MIC value of 19.06microg/ml was observed with the crude extract on seven microorganisms namely Citrobacter freundii, Enterobacter aerogens, Proteus mirabilis, Proteus vulgaris, Bacillus megaterium, Bacillus stearothermophilus and Candida albicans. For the tested compounds, the lowest MIC value of 0.3microg/ml (on six of the 22 organisms tested) was obtained only with compound 1, which appeared as the most active compound. This lowest MIC value (0.3microg/ml) is about 4-fold lower than that of the RA, indicating the powerful and very interesting antimicrobial potential of isobavachalcone (1). The antimicrobial activities of DBT, as well as that of compounds 1, 3, 4, amentoflavone (5) are being reported for the first time.
    CONCLUSIONS:
    The overall results provide promising baseline information for the potential use of the crude extracts from DBT as well as some of the isolated compounds in the treatment of bacterial and fungal infections.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5478 mL 12.7392 mL 25.4784 mL 50.9567 mL 63.6959 mL
    5 mM 0.5096 mL 2.5478 mL 5.0957 mL 10.1913 mL 12.7392 mL
    10 mM 0.2548 mL 1.2739 mL 2.5478 mL 5.0957 mL 6.3696 mL
    50 mM 0.051 mL 0.2548 mL 0.5096 mL 1.0191 mL 1.2739 mL
    100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.5096 mL 0.637 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    AAL Toxin TD2; AAL Toxin TD2 CFN00008 176590-36-6 C27H49NO10 = 547.69 5mg QQ客服:1413575084
    Andropanoside; Andropanoside CFN97671 82209-72-1 C26H40O9 = 496.60 5mg QQ客服:2056216494
    日本续断皂甙E1; Japondipsaponin E1 CFN95354 175586-66-0 C59H96O26 = 1221.4 5mg QQ客服:1413575084
    AT9283; AT9283 CFN60390 896466-04-9 C19H23N7O2 = 381.43 5mg QQ客服:2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产