| In vitro: |
| Phytotherapy Research. 2006 July;20(7):610–613. | | Isolation of flavonoids, a biscoumarin and an amide from the flower buds of Daphne genkwa and the evaluation of their anti-complement activity[Reference: WebLink] | As part of an ongoing study aimed at identifying the anti-complement active compound from the flower buds of Daphne genkwa, ten flavonoids, one biscoumarin and one amide were isolated.
METHODS AND RESULTS:
Their structures were identified from spectroscopic and physicochemical data as genkwanin 5-O-β-d-primveroside (1), apigenin 7-O-β-d-glucuronide (2), genkwanin 5-O-β-d-glucopyranoside (3), Apigenin 5-O-beta-D-glucopyranoside (4), genkwanin (5), apigenin (6), luteolin 7-methyl ether (7), luteolin (8), daphnoretin (9), velutin (10), 7-methoxyacacetin (11) and aurantiamide acetate (12). Among them, compounds 9, 10 and 12 were isolated from this plant for the first time. The anti-complement activity of these compounds was tested against the classical pathway of the complement system.
CONCLUSIONS:
Among the compounds, daphnoretin (9) exhibited significant anti-complement activity with an IC50 value of 11.4 µm, whereas the other compounds were not active in the assay. |
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