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  • 中药标准品生产商,产品定制服务
  • 金柑苷

    Fortunellin

    金柑苷
    产品编号 CFN70305
    CAS编号 20633-93-6
    分子式 = 分子量 C28H32O14 = 592.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Fortunella japonica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    金柑苷 CFN70305 20633-93-6 1mg QQ客服:2056216494
    金柑苷 CFN70305 20633-93-6 5mg QQ客服:2056216494
    金柑苷 CFN70305 20633-93-6 10mg QQ客服:2056216494
    金柑苷 CFN70305 20633-93-6 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Toronto (Canada)
  • University Medical Center Mainz (Germany)
  • University of Vigo (Spain)
  • Chulalongkorn University (Thailand)
  • Universit?t Basel (Switzerland)
  • Regional Crop Research Institute (Korea)
  • University of Canterbury (New Zealand)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Mysore (India)
  • University of Amsterdam (Netherlands)
  • Korea Institute of Oriental Medicine (Korea)
  • Agricultural Research Organization (ARO) (Israel)
  • Auburn University (USA)
  • Michigan State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2016, 192:370-381
  • Molecules.2018, 23(10):E2638
  • Molecules 2021, 26(4),1092.
  • Front Plant Sci.2022, 13:982771.
  • Neurotoxicology.2022, 91:218-227.
  • Molecules.2016, 21(6)
  • J Exp Bot.2016, 67(12):3777-88
  • J of L. Chroma.&Related Tech2017, 252-258
  • J Ethnopharmacol.2019, 241:112025
  • Int J Cosmet Sci.2019, 41(1):12-20
  • Phytomedicine.2022, 100:154036.
  • Front. Plant Sci.2022, 13:757852.
  • Separations2021, 8(6),80.
  • Journal of Apiculture2019, 34(2):131-136
  • Kor. J. Herbol.2022, 37(5): 89-96.
  • New Zealand J. Forestry Sci.2014, 44:17
  • Chem Biol Interact.2016, 258:59-68
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Molecules.2019, 24(10):E1930
  • Inflammation2015, 38(1):445-55
  • Cell Rep.2020, 32(11):108158.
  • Regul Toxicol Pharmacol.2023, 142:105433.
  • LWT2021, 138:110397.
  • ...
  • 生物活性
    Description: Fortunellin is a potential anti-inflammation agent in inflammatory diseases, it targets miR-374a, which is a negative regulator of phosphatase and tensin homolog (PTEN). Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.
    Targets: miR-374a | PTEN | NF-κB | AMPK | Nrf2 | HO-1 | SOD | IKK | IκB
    In vitro:
    Biochemical and Biophysical Research Communications, 15 Jun 2017, 490(2):552-559.
    Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation.[Reference: WebLink]
    Inflammation and oxidative stress contribute to the progression of diabetic cardiomyopathy (DCM). The study was first designed to calculate the role of an anti-inflammatory and anti-oxidant Fortunellin (For) in high fructose-induced cardiac injury in diabetic mice.
    METHODS AND RESULTS:
    Fortunellin was found to be none of toxicity to mice and cells using various assays. High fructose was used to induce mice with diabetes. The heart histopathological changes and cardiac function were measured. Fortunellin significantly attenuated the score of histopathological alterations and alleviated heart function, accompanied with reduced inflammation and oxidative stress. The pro-inflammatory cytokines and the expression of p-IκB kinase α (IKKα), p-IκBα, and p-nuclear factor-κB (NF-κB) were dramatically reduced by Fortunellin, while superoxide dismutase (SOD), catalase (CAT), heme oxygenase-1 (HO-1) and p-AMP-activated protein kinase (AMPK) were significantly enhanced. Moreover, in H9C2 cells with nuclear factor erythroid 2-related factor 2 (Nrf2) knock-down abolished the prevention of Fortunellin against cardiac injury, proved by elevated inflammatory response and oxidative stress. Suppression of p-AMPK reduced the level of Nrf2 and HO-1 induced by Fortunellin, eliminating the protective role of Fortunellin.
    CONCLUSIONS:
    For the first time, our study suggested that Fortunellin protected against fructose-induced inflammation and oxidative stress by enhancing AMPK/Nrf2 pathway in diabetic mice and cardiomyocytes with fructose treatment.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6875 mL 8.4374 mL 16.8748 mL 33.7496 mL 42.187 mL
    5 mM 0.3375 mL 1.6875 mL 3.375 mL 6.7499 mL 8.4374 mL
    10 mM 0.1687 mL 0.8437 mL 1.6875 mL 3.375 mL 4.2187 mL
    50 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.675 mL 0.8437 mL
    100 mM 0.0169 mL 0.0844 mL 0.1687 mL 0.3375 mL 0.4219 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    23-羟基杧果酮酸; 23-Hydroxymangiferonic acid CFN97779 232266-08-9 C30H46O4 = 470.69 5mg QQ客服:3257982914
    柽柳黄素; Tamarixetin CFN97027 603-61-2 C16H12O7 = 316.3 5mg QQ客服:3257982914
    麦冬皂苷C; Ophiopogonin C CFN98556 911819-08-4 C46H72O17 = 897.06 5mg QQ客服:215959384
    RO4929097; RO4929097 CFN60213 847925-91-1 C22H20F5N3O3 = 469.4 5mg QQ客服:3257982914

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