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  • 蒙花苷

    Linarin

    蒙花苷
    产品编号 CFN98738
    CAS编号 480-36-4
    分子式 = 分子量 C28H32O14 = 592.6
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Uncaria sinensis (Oliv.) Havil.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蒙花苷 CFN98738 480-36-4 10mg QQ客服:1457312923
    蒙花苷 CFN98738 480-36-4 20mg QQ客服:1457312923
    蒙花苷 CFN98738 480-36-4 50mg QQ客服:1457312923
    蒙花苷 CFN98738 480-36-4 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Chinese University of Hong Kong (China)
  • Universiti Sains Malaysia (Malaysia)
  • Kazusa DNA Research Institute (Japan)
  • Florida International University (USA)
  • University of Bonn (Germany)
  • University of Cincinnati (USA)
  • Sapienza University of Rome (Italy)
  • University of Melbourne (Australia)
  • University of British Columbia (Canada)
  • University of South Australia (Australia)
  • Semmelweis Unicersity (Hungary)
  • University of Madras (India)
  • University of Wuerzburg (Germany)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmaceuticals (Basel).2021, 14(10):1046.
  • Sains Malaysiana2022, 51(4):1143-1154
  • Mol Cells.2015, 38(9):765-72
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • J of Apicultural Research2020, 10.1080
  • Cancers (Basel).2023, 15(1):37.
  • Nutr Res Pract.2023, 17(4):670-681.
  • J Food Sci Technol.2022, 59(1):212-219.
  • Molecules.2019, 24(24):E4536
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • Industrial Crops and Products2018, 353-362
  • Appl. Sci.2020, 10(16),5482.
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • J Biol Chem.2014, 289(3):1723-31
  • Arch Biochem Biophys.2020, 687:108384.
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • J Control Release.2021, 336:159-168.
  • Front Pharmacol.2019, 10:1355
  • Exp Parasitol.2018, 194:67-78
  • Sci Rep. 2017, 17332(7)
  • Agronomy2020, 10(10),1489
  • Environ Toxicol.2019, 34(4):513-520.
  • ...
  • 生物活性
    Description: Linarin possesses analgesic, antipyretic, anti-acetylcholinesterase, hepatoprotective ,anti-inflammatory and neuroprotective activities, it prevents Aβ(25-35)-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3β and up-regulates Bcl-2. Linarin can protect osteoblasts against hydrogen peroxide-induced osteoblastic dysfunction and may exert anti-resorptive actions, at least in part, via the reduction of RANKL and oxidative damage; it also can treat postmenopausal osteoporosis,it induces the osteogenic differentiation and mineralization of MC3T3-E1 osteoblastic cells by activating the BMP-2/RUNX2 pathway through PKA signalingin vitroand protected against OVX-induced bone lossin vivo.
    Targets: LTR | Caspase | TNF-α | STAT | AChR | IL Receptor | PI3K | Akt | PKA | Beta Amyloid | GSK-3 | NF-kB | Bcl-2/Bax
    In vitro:
    Eur J Pharmacol. 2014 Sep 5;738:66-73.
    Protective effect of linarin against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure.[Pubmed: 24877692]
    Linarin was isolated from Chrysanthemum indicum L. Fulminant hepatic failure is a serious clinical syndrome that results in massive inflammation and hepatocyte death. Apoptosis is an important cellular pathological process in d-galactosamine (GalN)/lipopolysaccharide (LPS)-induced liver injury, and regulation of liver apoptosis might be an effective therapeutic method for fulminant hepatic failure.
    METHODS AND RESULTS:
    This study examined the cytoprotective mechanisms of linarin against GalN/LPS-induced hepatic failure. Mice were given an oral administration of linarin (12.5, 25 and 50mg/kg) 1h before receiving GalN (800 mg/kg)/LPS (40 μg/kg). Linarin treatment reversed the lethality induced by GalN/LPS. After 6h of GalN/LPS injection, the serum levels of alanine aminotransferase, aspartate aminotransferase, tumor necrosis factor (TNF)-α, interleukin-6 and interferon-γ were significantly elevated. GalN/LPS increased toll-like receptor 4 and interleukin-1 receptor-associated kinase protein expression. These increases were attenuated by linarin. Linarin attenuated the increased expression of Fas-associated death domain and caspase-8 induced by GalN/LPS, reduced the cytosolic release of cytochrome c and caspase-3 cleavage induced by GalN/LPS, and reduced the pro-apoptotic Bim phosphorylation induced by GalN/LPS. However, linarin increased the level of anti-apoptotic Bcl-xL and phosphorylation of STAT3.
    CONCLUSIONS:
    Our results suggest that linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediated apoptotic pathways.
    Int J Mol Med. 2016 Apr;37(4):901-10.
    Linarin promotes osteogenic differentiation by activating the BMP-2/RUNX2 pathway via protein kinase A signaling.[Pubmed: 26935542 ]
    Linarin (LIN), a flavonoid which exerts both anti-inflammatory and antioxidative effects, has been found to promote osteogenic differentiation. However, the molecular mechanism of its effect on osteoblast differentiation was unclear.
    METHODS AND RESULTS:
    In the present study, LIN from Flos Chrysanthemi Indici (FCI) was isolated in order to investigate the underlying mechanisms of LIN on MC3T3-E1 cells (a mouse osteoblastic cell line) and the osteoprotective effect of LIN in mice which had undergone an ovariectomy (OVX). The results revealed that LIN enhanced osteoblast proliferation and differentiation in MC3T3-E1 cells dose‑dependently, with enhanced alkaline phosphatase (ALP) activity and mineralization of extracellular matrix. LIN upregulated osteogenesis-related gene expression, including that of ALP, runt‑related transcription factor 2 (RUNX2), osteocalcin (OCN), bone sialoprotein (BSP), and type I collagen (COL‑I). Pretreatment with noggin, a bone morphogenetic protein-2 (BMP-2) antagonist, meant that LIN-induced gene expression levels of COL-1, ALP, OCN, BSP and RUNX2 were significantly reduced, as shown by RT-qPCR. Western blot analysis showed that LIN dose‑dependently increased the protein levels of BMP-2 and RUNX2 and enhanced the phosphorylation of SMAD1/5. In addition, LIN dose‑dependently upregulated protein kinase A (PKA) expression. H-89 (a PKA inhibitor) partially blocked the LIN-induced protein increase in BMP-2, p-SMAD1/5 and RUNX2. We noted that LIN preserved the trabecular bone microarchitecture of ovariectomized mice in vivo. Moreover, pretreatment with LIN significantly lowered serum levels of ALP and OCN in ovariectomized mice.
    CONCLUSIONS:
    Our data indicated that LIN induced the osteogenic differentiation and mineralization of MC3T3-E1 osteoblastic cells by activating the BMP-2/RUNX2 pathway through PKA signaling in vitro and protected against OVX-induced bone loss in vivo. The results strongly suggest that LIN is a useful natural alternative for the management of postmenopausal osteoporosis.
    Cell Immunol. 2011;268(2):112-6.
    Linarin isolated from Buddleja officinalis prevents hydrogen peroxide-induced dysfunction in osteoblastic MC3T3-E1 cells.[Pubmed: 21420072]
    The flowers and leaves buds of Buddleja officinalis MAXIM (Buddlejaceae) are used to treat eye troubles, hernia, gonorrhea and liver troubles in Asia.
    METHODS AND RESULTS:
    To elucidate the protective effects of linarin isolated from B. officinalis on the response of osteoblast to oxidative stress, osteoblastic MC3T3-E1 cells were pre-incubated with linarin for 1h before treatment with 0.3mM H(2)O(2) for 48h, and markers of osteoblast function and oxidative damage were examined. Linarin significantly (P<0.05) increased cell survival, alkaline phosphatase (ALP) activity, collagen content, calcium deposition, and osteocalcin secretion and decreased the production of receptor activator of nuclear factor-kB ligand (RANKL), protein carbonyl (PCO), and malondialdehyde (MDA) of osteoblastic MC3T3-E1 cells in the presence of hydrogen peroxide.
    CONCLUSIONS:
    These results demonstrate that linarin can protect osteoblasts against hydrogen peroxide-induced osteoblastic dysfunction and may exert anti-resorptive actions, at least in part, via the reduction of RANKL and oxidative damage.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6875 mL 8.4374 mL 16.8748 mL 33.7496 mL 42.187 mL
    5 mM 0.3375 mL 1.6875 mL 3.375 mL 6.7499 mL 8.4374 mL
    10 mM 0.1687 mL 0.8437 mL 1.6875 mL 3.375 mL 4.2187 mL
    50 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.675 mL 0.8437 mL
    100 mM 0.0169 mL 0.0844 mL 0.1687 mL 0.3375 mL 0.4219 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2,6-Tropanediol; 2,6-Tropanediol CFN00156 65356-02-7 C8H15NO2 = 157.21 5mg QQ客服:2159513211
    Jatairidoid A; Jatairidoid A CFN95668 1393577-29-1 C19H28O8 = 384.4 5mg QQ客服:215959384
    (-)-β-盾叶鬼臼素-5-O-β-葡萄糖甙; (-)-beta-Peltatin-5-O-beta-D-glucopyranoside CFN92700 11024-59-2 C28H32O13 = 576.6 5mg QQ客服:1413575084
    Triptonodiol; Triptonodiol CFN96476 117456-87-8 C21H30O4 = 346.46 5mg QQ客服:2056216494

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