7-(4-羟苯基)-1-苯基-4-庚烯-3-酮

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one

	产品编号	CFN95140
	CAS编号	100667-52-5
	分子式 = 分子量	C₁₉H₂₀O₂ = 280.4
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Phenols
	植物来源	The rhizomes of Curcuma longa L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
7-(4-羟苯基)-1-苯基-4-庚烯-3-酮	CFN95140	100667-52-5	1mg	QQ客服：215959384
7-(4-羟苯基)-1-苯基-4-庚烯-3-酮	CFN95140	100667-52-5	5mg	QQ客服：215959384
7-(4-羟苯基)-1-苯基-4-庚烯-3-酮	CFN95140	100667-52-5	10mg	QQ客服：215959384
7-(4-羟苯基)-1-苯基-4-庚烯-3-酮	CFN95140	100667-52-5	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Wollongong (Australia)

National Chung Hsing University (Taiwan)

Yale University (USA)

University of Illinois at Chicago (USA)

Kyoto University (Japan)

Institute of Pathophysiology Medical University of Vienna (Austria)

Shanghai University of TCM (China)

Biotech R&D Institute (USA)

Georgia Institute of Technology (USA)

Nicolaus Copernicus Uniwersity (Poland)

Kyushu University (Japan)

Universidade Federal de Santa Catarina (Brazil)

Universidade de Franca (Brazil)

Universiti Kebangsaan Malaysia (Malaysia)

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Description:

7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's disease (AD).

Targets:

Amyloid-β | PI3K | mTOR

In vitro:

Biol Pharm Bull. 2016 Dec 1;39(12):1961-1967.

7-(4-Hydroxyphenyl)-1-phenyl-4E-hepten-3-one, a Diarylheptanoid from Alpinia officinarum, Protects Neurons against Amyloid-β Induced Toxicity.[Pubmed: 27615431 ]

Amyloid-β (Aβ) is one of the major causative agents of Alzheimer's disease (AD), the most common neurodegenerative disorder characterized by progressive cognitive impairment. While effective drugs for AD are currently limited, identifying anti-Aβ compounds from natural products has been shown as a promising strategy which may lead to breakthroughs for new drug candidate discovery. We have previously reported that 7-(4-hydroxyphenyl)-1-phenyl-4E-hepten-3-one (7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one ,AO-1), a diarylheptanoid extracted from the plant Alpinia officinarum, has strong effects on neuronal differentiation and neurite outgrowth in vitro and in vivo.
METHODS AND RESULTS:
The present study further uncovers that AO-1 exerts neuroprotective effects against the neurotoxicity caused by Aβ. Under the damage of Aβ oligomers, the major pathological forms of Aβ, dendrites of neurons become atrophic and simplified, but such impairments were substantially alleviated by AO-1 treatment. Moreover, AO-1 reduced apoptotic levels and oxidative stress triggered by Aβ. Further analysis showed that the anti-caspase and dendrite protective effects of AO-1 were dependent on activation of phosphatidylinositol 3-kinase (PI3K)-mammalian target of rapamycin (mTOR) pathways.
CONCLUSIONS:
These findings collectively identify AO-1 as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of AD.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Daphnenone; Daphnenone	CFN92257	936006-13-2	C₁₇H₁₆O₂ = 252.3	5mg	QQ客服：215959384
3-羟基-1,5-二苯基-1-戊酮; 3-Hydroxy-1,5-diphenyl-1-pentanone	CFN92628	60669-64-9	C₁₇H₁₈O₂ = 254.3	5mg	QQ客服：2056216494
瑞香酮; Daphneolone	CFN92258	54835-64-2	C₁₇H₁₈O₃ = 270.3	5mg	QQ客服：215959384
1,7-二苯基-4-庚烯-3-酮; 1,7-Diphenyl-4-hepten-3-one	CFN92685	79559-59-4	C₁₉H₂₀O = 264.4	5mg	QQ客服：2159513211
7-(4-羟苯基)-1-苯基-4-庚烯-3-酮; 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one	CFN95140	100667-52-5	C₁₉H₂₀O₂ = 280.4	5mg	QQ客服：1413575084
7-(4-羟基-3-甲氧基苯基)-1-苯基-4-庚烯-3-酮; 7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB)	CFN95139	79559-60-7	C₂₀H₂₂O₃ = 310.4	20mg	QQ客服：1413575084
桤木酮; Alnustone	CFN90620	33457-62-4	C₁₉H₁₈O = 262.35	20mg	QQ客服：215959384
1,7-二苯基-5-羟基-4,6-庚烯-3-酮; 1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one	CFN95171	87095-77-0	C₁₉H₁₈O₂ = 278.4	10mg	QQ客服：215959384
(R)-5-羟基-1,7-二苯基-3-庚酮; (R)-5-Hydroxy-1,7-diphenyl-3-heptanone	CFN92684	100761-20-4	C₁₉H₂₂O₂ = 282.4	5mg	QQ客服：2159513211
5-羟基-1-(4-羟基苯基)-7-苯基-3-庚酮; 5-Hydroxy-1-(4-hydroxyphenyl)-7-phenyl-3-heptanone (AO 2210)	CFN95137	105955-04-2	C₁₉H₂₂O₃ = 298.4	20mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5663 mL	17.8317 mL	35.6633 mL	71.3267 mL	89.1583 mL
5 mM	0.7133 mL	3.5663 mL	7.1327 mL	14.2653 mL	17.8317 mL
10 mM	0.3566 mL	1.7832 mL	3.5663 mL	7.1327 mL	8.9158 mL
50 mM	0.0713 mL	0.3566 mL	0.7133 mL	1.4265 mL	1.7832 mL
100 mM	0.0357 mL	0.1783 mL	0.3566 mL	0.7133 mL	0.8916 mL