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  • 齐墩果酸3-乙酸酯

    • 齐墩果酸3-乙酸酯

    3-O-Acetyloleanolic acid

    齐墩果酸3-乙酸酯
    		产品编号 CFN98668
    CAS编号 4339-72-4
    分子式 = 分子量 C32H50O4 = 498.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Phytolacca americana
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    齐墩果酸3-乙酸酯 CFN98668 4339-72-4 1mg QQ客服：1413575084
    齐墩果酸3-乙酸酯 CFN98668 4339-72-4 5mg QQ客服：1413575084
    齐墩果酸3-乙酸酯 CFN98668 4339-72-4 10mg QQ客服：1413575084
    齐墩果酸3-乙酸酯 CFN98668 4339-72-4 20mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
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  • Institute of Chinese Materia Medica (China)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • bioRxiv - Molecular Biology2023, 535548.
  • Int Immunopharmacol.2020, 90:107268.
  • Saudi Pharmaceutical Journal2023, 31(12):101829
  • Biosci Rep.2020, 40(8):BSR20201219.
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Toxins (Basel).2021, 13(12):898.
  • American Association for Anatomy2020, doi: 10.1002.
  • Applied Biological Chemistry2021, 64(4)
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Front Pharmacol.2017, 8:205
  • Exp Neurobiol.2018, 27(3):200-209
  • J Am Soc Mass Spectrom.2021, 32(5):1205-1214.
  • bioRxiv2021, 458409.
  • Toxins (Basel).2019, 11(10):E575
  • Appl. Sci.2020, 10,1304
  • Korean J Dent Mater2020, 47(2):63-70.
  • Daru.2022, 30(2):273-288.
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • Enzyme Microb Technol.2019, 122:64-73
  • Int J Biol Macromol.2018, 112:1093-1103
  • Nat Prod Commun.2014, 9(5):679-82
  • Evid Based Complement Alternat Med.2021, 8855980.
  • Antioxidants (Basel).2021, 10(8):1300.
  • ...
    • 生物活性
    Description: 3-O-Acetyloleanolic acid exhibits anti-angiogenic effects, it inhibits proliferation, migration and tube formation of umbilical vein endothelial cells (HUVECs) in a dose-dependent manner; it can inhibit VEGF-A-induced lymphangiogenesis and lymph node metastasis in an oral squamous cell carcinoma animal model. 3-O-Acetyloleanolic acid has antihyperglycemic activity, it shows a significant decrease in the glucose level of STZ-induced diabetic rats.
    Targets: Caspase | VEGFR
    In vitro:
    Biotechnol Lett. 2013 Nov;35(11):1807-15.
    3-O-Acetyloleanolic acid exhibits anti-angiogenic effects and induces apoptosis in human umbilical vein endothelial cells.[Pubmed: 23801119]
    3-O-Acetyloleanolic acid, a pentacyclic triterpenoid isolated from cowpea seeds, inhibited proliferation, migration and tube formation of human umbilical vein endothelial cells (HUVECs) in a dose-dependent manner. HUVECs.
    METHODS AND RESULTS:
    The induced apoptosis was characterized by detection of cell surface annexin V and sub-G1 populations. The number of cells immunostained with annexin V-fluorescein isothiocyanate increased after treatment with 3-O-acetyloleanolic acid. The sub-G1 cell populations were also increased in treated HUVECs. 3-O-Acetyloleanolic acid induced activation of caspase 3, a critical mediator of apoptosis signaling. It also significantly inhibited angiogenesis in an in vivo Matrigel plug assay.
    CONCLUSIONS:
    3-O-Acetyloleanolic acid thus exhibits anti-angiogenic effects and induces apoptosis in HUVECs and the results suggest that it has a potential use for suppression of the tumor growth stimulated by angiogenesis.
    In vivo:
    J Nat Prod. 2006 Dec;69(12):1687-91.
    Antihyperglycemic activity and chemical constituents of Eysenhardtia platycarpa.[Pubmed: 17190443]
    The methanolic extracts from branches (BEP) and leaves (LEP) of Eysenhardtia platycarpa significantly decreased the blood glucose levels in normal and streptozotocin (STZ)-induced diabetic rats.
    METHODS AND RESULTS:
    One new flavone, (1"R)-5,4',1"-trihydroxy-6,7-(3",3"-dimethylchroman)flavone (1), together with the known compounds 5,7-dihydroxy-6-methyl-8-prenylflavanone (3), 5,7-dihydroxy-8-methyl-6-prenylflavanone (4), 5,7-dihydroxy-6-prenylflavanone (5), 5,7-dihydroxy-8-prenylflavanone (6), 3-O-acetyloleanolic acid (7), oleanolic acid, 3beta-acetoxy-11alpha,12alpha-epoxy-oleanan-28,13beta-olide, lupeol, betulinic acid, beta-sitosterol, beta-sitosteryl beta-D-glucopyranoside, beta-sitosteryl palmitate, and 3-O-methyl-myo-inositol were isolated from BEP. Additionally, one new flavanone, (2S)-4'-O-methyl-6-methyl-8-prenylnaringenin (2), as well as the known compounds 3, 4, 6, 4'-O-methyl-8-prenylnaringenin (8), and 5-hydroxy-7-methoxy-8-prenylflavanone (9) were isolated from LEP. 3-O-Acetyloleanolic acid (7), identified as the major constituent of BEP, showed a significant decrease (31 mg/kg of body weight, P < 0.05) in the glucose level of STZ-induced diabetic rats.
    CONCLUSIONS:
    The obtained results correlate with the traditional use of this species.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0048 mL 10.0241 mL 20.0481 mL 40.0962 mL 50.1203 mL
    5 mM 0.401 mL 2.0048 mL 4.0096 mL 8.0192 mL 10.0241 mL
    10 mM 0.2005 mL 1.0024 mL 2.0048 mL 4.0096 mL 5.012 mL
    50 mM 0.0401 mL 0.2005 mL 0.401 mL 0.8019 mL 1.0024 mL
    100 mM 0.02 mL 0.1002 mL 0.2005 mL 0.401 mL 0.5012 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    齐墩果酸3-乙酸酯; 3-O-Acetyloleanolic acid CFN98668 4339-72-4 C32H50O4 = 498.8 10mg QQ客服：1457312923
    3-O-对香豆酰齐墩果酸; 3-O-p-Coumaroyloleanolic acid CFN96043 151334-06-4 C39H54O5 = 602.9 5mg QQ客服：2159513211
    3-O-咖啡酰基齐墩果酸; 3-O-Caffeoyloleanolic acid CFN96050 97534-10-6 C39H54O6 = 618.9 5mg QQ客服：215959384
    3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid; 3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid CFN95710 469895-08-7 C32H50O5 = 514.8 5mg QQ客服：215959384
    3-氧代-12-烯-28-齐墩果酸; 3-oxo-Olean-12-en-28-oic acid CFN92194 17990-42-0 C30H46O3 = 454.7 20mg QQ客服：1413575084
    3-Keto-齐墩果酸-28-甲酯; 3-Oxo-olean-12-en-28-oic acid methyl ester CFN91814 1721-58-0 C31H48O3 = 468.7 5mg QQ客服：1457312923
    Virgatic acid; Virgatic acid CFN96451 14356-51-5 C30H46O4 = 470.70 5mg QQ客服：2159513211
    刺囊酸; Echinocystic acid CFN98812 510-30-5 C30H48O4 = 472.7 20mg QQ客服：1457312923
    3alpha-木通萜酸; 3alpha-Akebonoic acid CFN99067 104777-61-9 C29H44O3 = 440.7 5mg QQ客服：1457312923
    Sebiferenic acid; Sebiferenic acid CFN97523 94390-09-7 C30H48O4 = 472.7 5mg QQ客服：1413575084

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