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  • 3-氧代-12-烯-28-齐墩果酸

    3-oxo-Olean-12-en-28-oic acid

    3-氧代-12-烯-28-齐墩果酸
    产品编号 CFN92194
    CAS编号 17990-42-0
    分子式 = 分子量 C30H46O3 = 454.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The leaves of Eriobotrya japonica Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-氧代-12-烯-28-齐墩果酸 CFN92194 17990-42-0 10mg QQ客服:1457312923
    3-氧代-12-烯-28-齐墩果酸 CFN92194 17990-42-0 20mg QQ客服:1457312923
    3-氧代-12-烯-28-齐墩果酸 CFN92194 17990-42-0 50mg QQ客服:1457312923
    3-氧代-12-烯-28-齐墩果酸 CFN92194 17990-42-0 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Virginia (USA)
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  • Universiti Kebangsaan Malaysia (Malaysia)
  • University of Vigo (Spain)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Chiang Mai University (Thailand)
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  • Shanghai Institute of Organic Chemistry (China)
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  • Monash University (Australia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Vietnam Journal of Science2022,64(2):69-75.
  • Phytochemistry Letters2017, 449-455
  • Braz J Med Biol Res.2021, 54(12):e11183.
  • Appl. Sci. 2021, 11(22),10569
  • Postharvest Biol Tec2019, 149:18-26
  • Neurochem Int.2020, 133:104629
  • Journal of Chromatography A2020, 460942
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Int J Mol Sci.2022, 23(24):16000.
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Front Pharmacol.2021, 12:762829.
  • Food Chem.2020, 327:126992.
  • J Nat Prod.2015, 78(6):1339-4
  • Heliyon.2023, 9:e21652.
  • J. of Med. Plant Research.2013, 90-151
  • Nutrients2022, 14(3),695.
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • Food Research2021, 5(1):65-71
  • Sci Adv.2018, 4(10)
  • J Ginseng Res.2022, 46(1):104-114.
  • Hum Exp Toxicol.2023, 42:9603271221145386.
  • Food Chem.2019, 278:683-691
  • Molecules.2021, 26(8):2161.
  • ...
  • 生物活性
    Description: 3-oxo-Olean-12-en-28-oic acid and kulinone have cytotoxic effects, with IC50 values of 5.6-21.2 μg/mL.
    In vitro:
    Planta Med., 2011, 77(9):922-8.
    Cytotoxic triterpenoids and steroids from the bark of Melia azedarach.[Pubmed: 21243584]
    Two new triterpenoids (1, 2) and two new steroids (3, 4) along with twelve related known compounds (5-16) were isolated from the bark of Melia azedarach.
    METHODS AND RESULTS:
    The new structures were elucidated by means of spectroscopic methods and molecular modeling studies and found to be 21,24-cycloeupha-7-ene-3 β,16 β,21 α,25-tetrol (1), 3 β-acetoxy-12 β-hydroxy-eupha-7,24-dien-21,16 β-olide (2), 29-hydroperoxy-stigmasta-7,24(28) E-dien-3 β-ol (3), and 24 ξ-hydroperoxy-24-vinyl-lathosterol (4). All isolated compounds were tested for their cytotoxic activity against three human cancer cell lines (A549, H460, HGC27) using the CellTiter Glo™ luminescent cell viability assay.
    CONCLUSIONS:
    Among them, compounds 2- 4, 24 ξ-hydroperoxy-24-vinyl-cholesterol (6), kulinone (7), meliastatin 3 ( 8), 3-oxo-Olean-12-en-28-oic acid (10), and (22 E,24 S)-5 α,8 α-epidioxy-24-methyl-cholesta-6,22-dien-3 β-ol (12) were found to have cytotoxic effects, with IC₅₀ values of 5.6-21.2 μg/mL.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1993 mL 10.9963 mL 21.9925 mL 43.985 mL 54.9813 mL
    5 mM 0.4399 mL 2.1993 mL 4.3985 mL 8.797 mL 10.9963 mL
    10 mM 0.2199 mL 1.0996 mL 2.1993 mL 4.3985 mL 5.4981 mL
    50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0996 mL
    100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    齐墩果酸3-乙酸酯; 3-O-Acetyloleanolic acid CFN98668 4339-72-4 C32H50O4 = 498.8 10mg QQ客服:1413575084
    3-O-对香豆酰齐墩果酸; 3-O-p-Coumaroyloleanolic acid CFN96043 151334-06-4 C39H54O5 = 602.9 5mg QQ客服:3257982914
    3-O-咖啡酰基齐墩果酸; 3-O-Caffeoyloleanolic acid CFN96050 97534-10-6 C39H54O6 = 618.9 5mg QQ客服:2159513211
    3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid; 3alpha-Acetyloxy-25-hydroxyolean-12-en-28-oic acid CFN95710 469895-08-7 C32H50O5 = 514.8 5mg QQ客服:215959384
    3-氧代-12-烯-28-齐墩果酸; 3-oxo-Olean-12-en-28-oic acid CFN92194 17990-42-0 C30H46O3 = 454.7 20mg QQ客服:1413575084
    3-Keto-齐墩果酸-28-甲酯; 3-Oxo-olean-12-en-28-oic acid methyl ester CFN91814 1721-58-0 C31H48O3 = 468.7 5mg QQ客服:2159513211
    Virgatic acid; Virgatic acid CFN96451 14356-51-5 C30H46O4 = 470.70 5mg QQ客服:215959384
    刺囊酸; Echinocystic acid CFN98812 510-30-5 C30H48O4 = 472.7 20mg QQ客服:2056216494
    3alpha-木通萜酸; 3alpha-Akebonoic acid CFN99067 104777-61-9 C29H44O3 = 440.7 5mg QQ客服:1413575084
    Sebiferenic acid; Sebiferenic acid CFN97523 94390-09-7 C30H48O4 = 472.7 5mg QQ客服:2056216494

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