3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇

3-O-(2'E,4'Z-Decadienoyl)ingenol

	产品编号	CFN92867
	CAS编号	84680-59-1
	分子式 = 分子量	C₃₀H₄₂O₆ = 498.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The roots of Euphorbia kansui T. N. Liou ex S. B. Ho
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇	CFN92867	84680-59-1	1mg	QQ客服：215959384
3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇	CFN92867	84680-59-1	5mg	QQ客服：215959384
3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇	CFN92867	84680-59-1	10mg	QQ客服：215959384
3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇	CFN92867	84680-59-1	20mg	QQ客服：215959384

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Sao Paulo (Brazil)

University of Hull (United Kingdom)

Harvard University (USA)

Kyushu University (Japan)

Weizmann Institute of Science (Israel)

University of Illinois (USA)

University of Bonn (Germany)

Worcester Polytechnic Institute (USA)

Chang Gung University (Taiwan)

Monash University (Australia)

University of Eastern Finland (Finland)

Uniwersytet Gdański (Poland)

Korea Intitute of Science and Technology (KIST) (Korea)

Utrecht University (Netherlands)

More...

Description:

Kansuiphorin C and 3-O-(2′E,4′Z-decadienoyl)-ingenol exhibit significant anticomplement activity with respective 50% inhibitory concentration values of 44.1±3.8 and 89.5±5.5 uM. 20-O-acetyl-[3-O-(2'E,4'Z)-decadienoyl]-ingenol and 3-O-(2'E,4'Z)-decadienoylingenol show the same antinematodal activity against the nematode, Bursaphelenchus xylophilus, at a minimum effective dose (MED) of 5 microg/cotton ball.

Targets:

Topoisomerase | Antifection

In vitro:

Cancer Sci. 2010 Feb;101(2):374-8.

Analysis of inhibition of topoisomerase IIalpha and cancer cell proliferation by ingenolEZ.[Pubmed: 20175785]

We previously reported that many ingenol compounds derived from Euphorbia kansui exhibit topoisomerase inhibitory activity and/or inhibitory activity of cell proliferation.
METHODS AND RESULTS:
The inhibitory effects of 20-O-(2'E,4'Z-decadienoyl) ingenol and 3-O-(2'E,4'Z-Decadienoyl)ingenol among these compounds on topoisomerase II activity and on the cell proliferative activity and arrest phase of the cell cycle were studied using a mouse breast cancer (MMT) cell line. Although 20-O-ingenolEZ exerted inhibitory effects on both topoisomerase II activity and cell proliferative activity, 3-O-ingenolEZ exerted inhibitory activity on neither. The 20-O-ingenolEZ-induced cell arrest of MMT-cell proliferation led to a cell cycle arrest in the G2/M phase. Topoisomerase II inhibition can be divided into the poison and catalytic inhibitor types. A checkpoint mechanism is activated when cells are treated with these topoisomerase II inhibitors.
CONCLUSIONS:
Poison-type inhibition occurs via induction of the DNA damage checkpoint and the catalytic-type inhibition occurs via induction of the DNA-decatenation checkpoint, suggestive of distinct checkpoint reactions. 20-O-ingenolEZ inhibited topoisomerase IIalpha activity through inhibition of ATPase, and induced DNA-decatenation checkpoint without signaling for phosphorylation of H2AX.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3-O-(2'E,4'E-癸二烯酰基)巨大戟二萜醇; 3-O-(2'E,4'E-Decadienoyl)ingenol	CFN92868	466663-11-6	C₃₀H₄₂O₆ = 498.7	5mg	QQ客服：2159513211
3-O-(2'E,4'E-癸二烯酰基)-20-O-乙酰巨大戟二萜醇; 3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol	CFN92865	466663-12-7	C₃₂H₄₄O₇ = 540.7	5mg	QQ客服：3257982914
Ingenol 3-palmitate; Ingenol 3-palmitate	CFN89409	52557-26-3	C₃₆H₅₈O₆ = 586.84	5mg	QQ客服：3257982914
Ingenol 20-palmitate; Ingenol 20-palmitate	CFN89401	39071-33-5	C₃₆H₅₈O₆ = 586.84	5mg	QQ客服：3257982914
13-O-正十二烷酸巨大戟酯; 13-Oxyingenol dodecanoat	CFN93244	54706-70-6	C₃₂H₅₀O₇ = 546.74	5mg	QQ客服：2056216494
12-O-十四烷酰佛波醋酸酯-13; 12-O-tetradecanoylphorbol-13-acetate	CFN90367	16561-29-8	C₃₆H₅₆O₈ = 616.83	10mg	QQ客服：3257982914
Euphohelioscopin A; Euphohelioscopin A	CFN96233	87064-61-7	C₃₀H₄₂O₆ = 498.7	5mg	QQ客服：2056216494
Lathyranoic acid A; Lathyranoic acid A	CFN95325	850560-44-0	C₂₉H₃₄O₇ = 494.6	5mg	QQ客服：1413575084
3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇; 3-O-(2'E,4'Z-Decadienoyl)ingenol	CFN92867	84680-59-1	C₃₀H₄₂O₆ = 498.7	5mg	QQ客服：215959384
3-O-(2'E,4'Z-癸二烯酰基)-20-O-乙酰巨大戟二萜醇; 3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol	CFN92864	158850-76-1	C₃₂H₄₄O₇ = 540.7	5mg	QQ客服：2056216494

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0052 mL	10.0261 mL	20.0521 mL	40.1043 mL	50.1303 mL
5 mM	0.401 mL	2.0052 mL	4.0104 mL	8.0209 mL	10.0261 mL
10 mM	0.2005 mL	1.0026 mL	2.0052 mL	4.0104 mL	5.013 mL
50 mM	0.0401 mL	0.2005 mL	0.401 mL	0.8021 mL	1.0026 mL
100 mM	0.0201 mL	0.1003 mL	0.2005 mL	0.401 mL	0.5013 mL