12-O-十四烷酰佛波醋酸酯-13

12-O-tetradecanoylphorbol-13-acetate

	产品编号	CFN90367
	CAS编号	16561-29-8
	分子式 = 分子量	C₃₆H₅₆O₈ = 616.83
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Diterpenoids
	植物来源	The seeds of Euphorbia lathyris L.
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产品名称	产品编号	CAS编号	包装	QQ客服
12-O-十四烷酰佛波醋酸酯-13	CFN90367	16561-29-8	1mg	QQ客服：1413575084
12-O-十四烷酰佛波醋酸酯-13	CFN90367	16561-29-8	5mg	QQ客服：1413575084
12-O-十四烷酰佛波醋酸酯-13	CFN90367	16561-29-8	10mg	QQ客服：1413575084
12-O-十四烷酰佛波醋酸酯-13	CFN90367	16561-29-8	20mg	QQ客服：1413575084

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Description:

12-O-tetradecanoylphorbol-13-acetate has skin tumor-promoting potential, it induces endogenous FBXO10 mRNA and FBXO10 protein in Jurkat cells, a human T cell line. It provokes cell motility through regulating the expression and function of S100A14 in a KLF4-dependent manner.

Targets:

PKC | AP-1

In vitro:

J Biol Chem. 2014 Mar 28;289(13):9089-99.

12-O-tetradecanoylphorbol-13-acetate promotes breast cancer cell motility by increasing S100A14 level in a Kruppel-like transcription factor 4 (KLF4)-dependent manner.[Pubmed: 24532790]

The S100 protein family represents the largest subgroup of calcium binding EF-hand type proteins. These proteins have been reported to be involved in a wide range of biological functions that are related to normal cell development and tumorigenesis. S100A14 is a recently identified member of the S100 protein family and differentially expressed in a number of different human malignancies. However, the transcriptional regulation of S100A14 and its role in breast cancer needs to be further investigated.
METHODS AND RESULTS:
Here, we determined that 12-O-tetradecanoylphorbol-13-acetate (TPA) up-regulated the expression of KLF4 and facilitated its binding directly to two conserved GC-rich DNA segments within the S100A14 promoter, which is essential for the transactivation of KLF4 induced S100A14 expression. Furthermore, stable silencing of KLF4 significantly suppressed breast cancer cell migration induced by TPA.
CONCLUSIONS:
Collectively, these results offer insights into the fact that TPA provokes cell motility through regulating the expression and function of S100A14 in a KLF4-dependent manner.

In vivo:

J Pharm Pharmacol. 2013 Aug;65(8):1223-30.

Structure-dependent inhibitory effects of synthetic cannabinoids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice.[Pubmed: 23837590]

METHODS AND RESULTS:
Twenty-three analogues of synthetic cannabinoids were isolated from, and identified as adulterants in, illegal drugs distributed in the Tokyo metropolitan area, and were examined for their inhibitory effects on the induction of oedema in mouse ears by 12-O-tetradecanoylphorbol-13-acetate (TPA). Furthermore, selected cannabinoids, JWH-018, -122 and -210, were studied for their effects on carcinogenesis induced in mouse skin initiated with 7,12-dimethylbenz[a]anthracene (DMBA) and promoted by 12-O-tetradecanoylphorbol-13-acetate. Among cannabinoids, naphthoylindoles mostly exhibited superior inhibitory effects against 12-O-tetradecanoylphorbol-13-acetate-induced ear oedema and, especially, JWH-018, -122 and -210 showed potent activity with 50% inhibitory dose (ID50) values of 168, 346 and 542 nm, respectively (an activity corresponding to that of indometacin (ID50 = 908 nm)). Furthermore these three compounds also markedly suppressed the tumour-promoting activity of 12-O-tetradecanoylphorbol-13-acetate.
CONCLUSIONS:
This is the first report indicating the structure-activity relationships for the anti-inflammatory activity of synthetic cannabinoids on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice. Naphthoylindoles, JWH-018, -122 and -210, had the most potent anti-inflammatory activity and also markedly inhibited tumour promotion by 12-O-tetradecanoylphorbol-13-acetate in the two-stage mouse skin carcinogenesis model. The present results suggest that synthetic cannabinoids, such as JWH-018, -122 and -210, may be used as cancer chemopreventive agents in the future.

Vet Pathol. 2013 Sep;50(5):903-8.

Tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in an ultra-short-term skin carcinogenesis bioassay using rasH2 mice.[Pubmed: 23610217]

METHODS AND RESULTS:
Assessment of the skin tumor-promoting potential of 12-O-tetradecanoylphorbol-13-acetate (TPA) after initiation with 7,12-dimethylbenz[a]anthracene (DMBA) was conducted using rasH2 transgenic (Tg) mice and their nontransgenic (non-Tg) littermates. Mice were treated with DMBA (50 μg/100 μL acetone) on clipped back skin at the commencement of the study, and 1 week thereafter, 12-O-tetradecanoylphorbol-13-acetate was applied at 8 μg/200 μL or 4 μg/200 μL acetone, once or twice weekly, for 7 weeks.In conclusion, skin promotion effects could be detected within only 8 weeks in the rasH2 mice, and the concentration of 4 μg 12-O-tetradecanoylphorbol-13-acetate once weekly was sufficient as a positive control.
CONCLUSIONS:
This short-term skin carcinogenesis bioassay using rasH2 mice could represent a useful tool for the assessment of drug and chemical safety with cutaneous treatment.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
13-O-正十二烷酸巨大戟酯; 13-Oxyingenol dodecanoat	CFN93244	54706-70-6	C₃₂H₅₀O₇ = 546.74	5mg	QQ客服：1413575084
12-O-十四烷酰佛波醋酸酯-13; 12-O-tetradecanoylphorbol-13-acetate	CFN90367	16561-29-8	C₃₆H₅₆O₈ = 616.83	10mg	QQ客服：2056216494
Euphohelioscopin A; Euphohelioscopin A	CFN96233	87064-61-7	C₃₀H₄₂O₆ = 498.7	5mg	QQ客服：215959384
Lathyranoic acid A; Lathyranoic acid A	CFN95325	850560-44-0	C₂₉H₃₄O₇ = 494.6	5mg	QQ客服：1457312923
3-O-(2'E,4'Z-癸二烯酰基)巨大戟二萜醇; 3-O-(2'E,4'Z-Decadienoyl)ingenol	CFN92867	84680-59-1	C₃₀H₄₂O₆ = 498.7	5mg	QQ客服：2159513211
3-O-(2'E,4'Z-癸二烯酰基)-20-O-乙酰巨大戟二萜醇; 3-O-(2'E ,4'Z-decadienoyl)-20-O-acetylingenol	CFN92864	158850-76-1	C₃₂H₄₄O₇ = 540.7	5mg	QQ客服：215959384
3-O-(2'E,4'E-癸二烯酰基)巨大戟二萜醇; 3-O-(2'E,4'E-Decadienoyl)ingenol	CFN92868	466663-11-6	C₃₀H₄₂O₆ = 498.7	5mg	QQ客服：2056216494
3-O-(2'E,4'E-癸二烯酰基)-20-O-乙酰巨大戟二萜醇; 3-O-(2'E ,4'E-decadienoyl)-20-O-acetylingenol	CFN92865	466663-12-7	C₃₂H₄₄O₇ = 540.7	5mg	QQ客服：1413575084
Ingenol 3-palmitate; Ingenol 3-palmitate	CFN89409	52557-26-3	C₃₆H₅₈O₆ = 586.84	5mg	QQ客服：2056216494
Ingenol 20-palmitate; Ingenol 20-palmitate	CFN89401	39071-33-5	C₃₆H₅₈O₆ = 586.84	5mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6212 mL	8.106 mL	16.2119 mL	32.4238 mL	40.5298 mL
5 mM	0.3242 mL	1.6212 mL	3.2424 mL	6.4848 mL	8.106 mL
10 mM	0.1621 mL	0.8106 mL	1.6212 mL	3.2424 mL	4.053 mL
50 mM	0.0324 mL	0.1621 mL	0.3242 mL	0.6485 mL	0.8106 mL
100 mM	0.0162 mL	0.0811 mL	0.1621 mL	0.3242 mL	0.4053 mL

12-O-十四烷酰佛波醋酸酯-13

12-O-tetradecanoylphorbol-13-acetate

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