2-羟基肉桂酸; 邻羟基肉桂酸

2-Hydroxycinnamic acid

	产品编号	CFN98193
	CAS编号	614-60-8
	分子式 = 分子量	C₉H₈O₃ = 164.16
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Phenylpropanoids
	植物来源	The herbs of Angraecum fragrans.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
2-羟基肉桂酸; 邻羟基肉桂酸	CFN98193	614-60-8	10mg	QQ客服：1457312923
2-羟基肉桂酸; 邻羟基肉桂酸	CFN98193	614-60-8	20mg	QQ客服：1457312923
2-羟基肉桂酸; 邻羟基肉桂酸	CFN98193	614-60-8	50mg	QQ客服：1457312923
2-羟基肉桂酸; 邻羟基肉桂酸	CFN98193	614-60-8	100mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universiti Kebangsaan Malaysia (Malaysia)

Technical University of Denmark (Denmark)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

Centrum Menselijke Erfelijkheid (Belgium)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Massachusetts General Hospital (USA)

University of Virginia (USA)

Uniwersytet Gdański (Poland)

University of Auckland (New Zealand)

University of Sao Paulo (Brazil)

University of Bonn (Germany)

University of Vienna (Austria)

St. Jude Children Research Hospital (USA)

University of Maryland School of Medicine (USA)

More...

Description:

2-Hydroxycinnamic acid has photooxidant activity; 2-hydroxycinnamic acid germanium has strong inhibitory effect on the tumor U14; trans-2-hydroxycinnamic acid has efficacy against trichlorfon-induced oxidative stress in wistar rats.

Targets:

SOD | LPO

In vivo:

Toxicol Int. 2012 Sep;19(3):295-300.

Efficacy of trans-2-hydroxycinnamic Acid against trichlorfon-induced oxidative stress in wistar rats.[Pubmed: 23293469]

Trichlorfon is an organophosphate insecticide used to control cockroaches, crickets, silverfish, bedbugs, fleas, cattle grubs, flies, ticks, leaf miners, and leaf-hoppers. It is also used to treat domestic animals for control of internal parasites. Trans-2-hydroxycinnamic acid (T2HCA) is a hydroxyl derivative of cinnamic acid. The present study highlights trichlorofon-induced toxicity and the protective role of T2HCA in the liver, kidney, and brain of female Wistar rats.
METHODS AND RESULTS:
The rats were given a single dose of trichlorofon (150 mg / kg bw) and pre- and post-treatment T2HCA (50 mg / kg bw) for seven days. Trichlorofon enhanced oxidative stress in liver, kidney, and brain of the rats, which was evident from the elevation of lipid peroxidation (LPO). The reduced level of non-enzymatic antioxidant glutathione (GSH) also indicated the presence of an oxidative insult. The activity of enzymatic antioxidants like superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx) was significantly decreased on trichlorfon administration. Pre and post treatment with T2HCA decreased the LPO level and increased SOD, CAT, GST, GR, GPx, and GSH in the brain, liver, and kidney. Trichlorfon-induced reduction in acelylcholinestrase was also ameliorated with T2HCA treatment.
CONCLUSIONS:
In conclusion, trichlorfon-mediated induction in the reactive oxygen species and disturbance in the antioxidant enzymes' defense system was moderately ameliorated by antioxidant trans-2-hydroxycinnamic acid.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
2-羟基肉桂酸; 邻羟基肉桂酸; 2-Hydroxycinnamic acid	CFN98193	614-60-8	C₉H₈O₃ = 164.16	20mg	QQ客服：215959384
2-甲氧基肉桂酸; 2-Methoxycinnamic acid	CFN98192	6099-03-2	C₁₀H₁₀O₃ = 178.18	20mg	QQ客服：3257982914
3-羟基肉桂酸; 间羟基肉桂酸; trans-3-Hydroxycinnamic acid	CFN98181	14755-02-3	C₉H₈O₃ = 164.16	20mg	QQ客服：1457312923
(alpha R)-3-羧基-alpha-羟基苯丙酸; Cerberic acid B	CFN97831	1309362-77-3	C₁₀H₁₀O₅ = 210.18	5mg	QQ客服：2159513211
对甲基肉桂酸; 4-Methylcinnamic acid	CFN98186	1866-39-3	C₁₀H₁₀O₂ = 162.19	20mg	QQ客服：3257982914
4-三氟甲基肉桂酸; trans-4-(Trifluoromethyl)cinnamic acid	CFN98188	16642-92-5	C₁₀H₇F₃O₂ = 216.16	20mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.0916 mL	30.4581 mL	60.9162 mL	121.8324 mL	152.2904 mL
5 mM	1.2183 mL	6.0916 mL	12.1832 mL	24.3665 mL	30.4581 mL
10 mM	0.6092 mL	3.0458 mL	6.0916 mL	12.1832 mL	15.229 mL
50 mM	0.1218 mL	0.6092 mL	1.2183 mL	2.4366 mL	3.0458 mL
100 mM	0.0609 mL	0.3046 mL	0.6092 mL	1.2183 mL	1.5229 mL