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  • 4-O-甲基根皮乙酰苯

    2',6'-Dihydroxy-4'-methoxyacetophenone

    4-O-甲基根皮乙酰苯
    产品编号 CFN96581
    CAS编号 7507-89-3
    分子式 = 分子量 C9H10O4 = 182.17
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The roots of Sanguisorba minor.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4-O-甲基根皮乙酰苯 CFN96581 7507-89-3 1mg QQ客服:1457312923
    4-O-甲基根皮乙酰苯 CFN96581 7507-89-3 5mg QQ客服:1457312923
    4-O-甲基根皮乙酰苯 CFN96581 7507-89-3 10mg QQ客服:1457312923
    4-O-甲基根皮乙酰苯 CFN96581 7507-89-3 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Research Square2022, rs.3.rs-1948239
  • Food Chem.2018, 252:207-214
  • Antioxidants (Basel).2022, 11(8):1471.
  • University of Stuttgart2021, 11682.
  • Hanoi University of Pharmacy2023, 14(1):30-39.
  • PLoS One.2021, 16(6):e0248479.
  • Pol J Microbiol.2021, 70(1):117-130.
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  • Comparative Clinical Pathology 2021, 30:961-971.
  • Adaptive Medicine 2020, 12(1): 4-10
  • Nat Prod Commun.2014, 9(5):679-82
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • Pharmacognosy Journal2019, 11(2): 369-373
  • J Med Food.2021, 24(3):209-217.
  • Cell Biochem Funct.2018, 36(6):303-311
  • J Applied Biological Chemistry2021, 64(2):185-192
  • Mol Neurobiol.2022, 02873-9.
  • Int J Mol Sci.2021, 22(9):5012.
  • Environ Toxicol.2021, doi: 10.1002
  • Int J Mol Sci.2022, 23(15):8687.
  • Journal of Food and Drug Analysis2023, 31(3), 9.
  • ...
  • 生物活性
    Description: 2',6'-Dihydroxy-4'-methoxyacetophenone is a phytoalexin after fungal inoculation with Botrytis cinerea or UV light irradiation, it has spore germination inhibition on Botrytis cinerea and Phomopsis perniciosa, with ED50 values of 45 and 410 uM, respectively. 2',6'-Dihydroxy-4'-methoxyacetophenone exhibits significant antifungal activities.
    Targets: Antifection
    In vitro:
    Phytochemistry, 1994, 35(2):331-3.
    2',6'-Dihydroxy-4'-methoxyacetophenone, a phytoalexin from the roots of Sanguisorba minor[Reference: WebLink]

    METHODS AND RESULTS:
    The root tissue of Sanguisorba minor produced 2',6'-Dihydroxy-4'-methoxyacetophenone as a phytoalexin after fungal inoculation with Botrytis cinerea or UV light irradiation.
    CONCLUSIONS:
    The ED50 of this compound on spore germination inhibition was 45 and 410 μM for Botrytis cinerea and Phomopsis perniciosa, respectively.
    Journal of the Japan Wood Research Society, 1997, 43:108-111.
    Antifungal activity of 2′,6′-dihydroxy-4′-methoxyacetophenone and related compounds[Reference: WebLink]

    METHODS AND RESULTS:
    We investigated the relationship between the antifungal activity of 2',6'-Dihydroxy-4'-methoxyacetophenone, a component found in the leaves of Rhododendron dauricum L. and of related compounds and their chemical structures, using several common plant pathogenic fungi. Acetophenones having hydroxyl and/or methoxyl substituents on their aromatic rings showed strong activity against all fungal species tested at a concentration of 500 μml-1. Mono-, 2′,4′-di-, 2′,5′-di-, 2′,6′-di- and 2′,4′,6′-tri-substituted acetophenones were generally more active than 3′4′-di-, 3′,5′-di-and 3′,4′,5′-tri-substituted ones. Although the hyphal growths of some fungi almost were inhibited completely by mono- and 2′,5′-di-substituted acetophenones, none of the fungi, with a few exceptions, were killed.
    CONCLUSIONS:
    2′,6′-Dihydroxyacetophenone and 2',6'-Dihydroxy-4'-methoxyacetophenone exhibited significant antifungal activities against all test fungi, whereas 2′-hydroxy-6′-methoxyacetophenone had limited activity. The ortho-hydroxyls to the acetyl in the molecules play an important role in antifungal activities, because methylation of the hydroxyls resulted in reduced activities. In contrast, the antifungal activities of 2′,4′-dihydroxyacetophenone and 2′,4′,6′-trihydroxyacetophenone were enhanced by the methylation of para-hydroxyl. The limited activity of 2′,4′,6′-trihydroxycetophenone suggested that one of the hydroxyls in the molecule was unfavorable for antifungal activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.4894 mL 27.4469 mL 54.8938 mL 109.7876 mL 137.2345 mL
    5 mM 1.0979 mL 5.4894 mL 10.9788 mL 21.9575 mL 27.4469 mL
    10 mM 0.5489 mL 2.7447 mL 5.4894 mL 10.9788 mL 13.7234 mL
    50 mM 0.1098 mL 0.5489 mL 1.0979 mL 2.1958 mL 2.7447 mL
    100 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.0979 mL 1.3723 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
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