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  • 麻风树碱5

    Jatrophane 5

    麻风树碱5
    产品编号 CFN98055
    CAS编号 210108-89-7
    分子式 = 分子量 C41H49NO14 = 779.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The branches of Jatropha carcas L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    麻风树碱5 CFN98055 210108-89-7 1mg QQ客服:2056216494
    麻风树碱5 CFN98055 210108-89-7 5mg QQ客服:2056216494
    麻风树碱5 CFN98055 210108-89-7 10mg QQ客服:2056216494
    麻风树碱5 CFN98055 210108-89-7 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Santa Catarina (Brazil)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Institute of Chinese Materia Medica (China)
  • Monash University (Australia)
  • University of Perugia (Italy)
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  • University of Malaya (Malaysia)
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  • University of Canterbury (New Zealand)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2017, 209:305-316
  • Oncol Lett.2020, 20(4):122.
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • Molecules.2020, 25(7):1625.
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Plants2022, 11(3),294.
  • Mol Immunol. 2016, 78:121-132
  • VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
  • Metabolites.2020, 11(1):E11.
  • Natural Product Communications2020, doi: 10.1177.
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Molecules.2022, 27(4):1412.
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Food Research International2016, 106-113
  • New Zealand J. Forestry Sci.2014, 44:17
  • Sci Rep.2019, 9:19059
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • BMC Plant Biol.2020, 20(1):214.
  • Nutraceutical Research . 2021, 19(1),p90-105.
  • FASEB J.2022, 36(7):e22387.
  • Appl. Sci.2020, 10,1304
  • The Journal of Supercritical Fluids2021, 176:105305.
  • ...
  • 生物活性
    Description: Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
    Targets: P-gp
    In vitro:
    Phytochemistry. 2013 Feb;86:208-17.
    Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines.[Pubmed: 23079764]

    METHODS AND RESULTS:
    Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed.
    CONCLUSIONS:
    Jatrophane 2 and Jatrophane 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2824 mL 6.4119 mL 12.8238 mL 25.6476 mL 32.0595 mL
    5 mM 0.2565 mL 1.2824 mL 2.5648 mL 5.1295 mL 6.4119 mL
    10 mM 0.1282 mL 0.6412 mL 1.2824 mL 2.5648 mL 3.206 mL
    50 mM 0.0256 mL 0.1282 mL 0.2565 mL 0.513 mL 0.6412 mL
    100 mM 0.0128 mL 0.0641 mL 0.1282 mL 0.2565 mL 0.3206 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘遂萜酯E; Kansuinine E CFN92869 672945-84-5 C41H47NO14 = 777.8 5mg QQ客服:1413575084
    Jatrophane I; Jatrophane I CFN89380 210108-85-3 C36H45NO13 = 699.74 5mg QQ客服:1413575084
    Jatrophane VI ; Jatrophane VI CFN89381 210108-90-0 C37H48O14 = 716.76 5mg QQ客服:1413575084
    麻风树碱4; Jatrophane 4 CFN98054 210108-88-6 C39H52O14 = 744.8 5mg QQ客服:2056216494
    麻风树碱2; Jatrophane 2 CFN98052 210108-86-4 C39H50O15 = 758.8 5mg QQ客服:2159513211
    麻风树碱5; Jatrophane 5 CFN98055 210108-89-7 C41H49NO14 = 779.8 5mg QQ客服:1457312923
    麻风树碱3; Jatrophane 3 CFN98053 210108-87-5 C43H53NO14 = 807.9 5mg QQ客服:2159513211
    Pepluanin A; Pepluanin A CFN97144 670257-89-3 C43H51NO15 = 821.9 5mg QQ客服:2159513211
    甘遂萜酯A; Kansuinine A CFN92863 57701-86-7 C37H46O15 = 730.8 5mg QQ客服:1413575084
    甘遂萜酯B; Kansuinine B CFN92866 57685-46-8 C38H42O14 = 722.7 5mg QQ客服:1413575084

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