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  • 2,3,23-三羟基-12-齐墩果烯-28-酸

    2,3,23-Trihydroxy-12-oleanen-28-oic acid

    2,3,23-三羟基-12-齐墩果烯-28-酸
    产品编号 CFN99041
    CAS编号 102519-34-6
    分子式 = 分子量 C30H48O5 = 488.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The leaves and roots of Camptotheca acuminata Decaisne
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2,3,23-三羟基-12-齐墩果烯-28-酸 CFN99041 102519-34-6 1mg QQ客服:3257982914
    2,3,23-三羟基-12-齐墩果烯-28-酸 CFN99041 102519-34-6 5mg QQ客服:3257982914
    2,3,23-三羟基-12-齐墩果烯-28-酸 CFN99041 102519-34-6 10mg QQ客服:3257982914
    2,3,23-三羟基-12-齐墩果烯-28-酸 CFN99041 102519-34-6 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • LWT2021, 150:112021.
  • Asian J Beauty Cosmetol2020, 18(3): 265-272.
  • Appl. Sci.2020, 10(20),7374.
  • Molecules.2017, 22(12)
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  • Acta Physiologiae Plantarum2015, 37:1736
  • Food Funct.2022, doi: 10.1039
  • Front Cell Dev Biol.2021, 9:764263.
  • Molecules.2021, 26(23):7390.
  • FEBS Lett.2015, 589(1):182-7
  • Food Chem.2019, 290:286-294
  • J Biol Chem.2014, 289(3):1723-31
  • Applied Biological Chemistry2020, 63:33(2020)
  • Institute of Food Science & Technology2021, 45(9).
  • Green Chemistry2021, ISSUE 2.
  • ...
  • 生物活性
    Description: 2β,3β,23α-Trihydroxy-12-oleanen-28-oic acid shows cytotoxic activities to human lung adenocarcinoma(A-549)cell lines. 2α,3β,23-Trihydroxyolean-12-en-28-oic acid and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibit cytotoxicity in vitro against the growth of human cancer cells lines HepG-2,with IC50 values of 16.13 ± 3.83, 15.97 ± 2.47 uM, respectively.
    In vitro:
    Lishizhen Medicine & Materia Medica Research, 2008,19(8):1931-2.
    Triterpenes from Glochidion coccineum and their Cytotoxicity in Vitro[Reference: WebLink]
    To study the chemical constituents of Glochidion coccineum and their cytotoxicity in vitro.
    METHODS AND RESULTS:
    Various column chromatographic technologies were applied for isolation and purification and the structures were elucidated by spectral evidence.MTT method was applied to investigate their cytotoxic activities. Six compounds were isolated from the part of ethyl acetate and identified as Glochidiol ①,Lup-20(29)-ene-1α,23-diol ②,Glochidone ③,Epi-lupeol ④,3β,19α,23α-trihydroxy-12-oleanen-28-oic acid ⑤,2β,3β,23α-trihydroxy-12-oleanen-28-oic acid(2,3,23-Trihydroxy-12-oleanen-28-oic acid ) ⑥.
    CONCLUSIONS:
    The above compounds were obtained from this plant for the first time;compounds 1~4 showed cytotoxic activities to human hepatoma(BEL-7402),as well as compounds 5 and 6 to lung adenocarcinoma(A-549)cell lines.
    Molecules. 2015 Oct 22;20(10):19252-62.
    Cytotoxicity of Triterpenes from Green Walnut Husks of Juglans mandshurica Maxim in HepG-2 Cancer Cells.[Pubmed: 26506336 ]
    Among the classes of identified natural products, triterpenoids, one of the largest families, have been studied extensively for their diverse structures and variety of biological activities, including antitumor effects.
    METHODS AND RESULTS:
    In the present study, a phytochemical study of the green walnut husks of Juglans mandshurica Maxim led to the isolation of a new dammarane triterpene, 12β, 20(R), 24(R)-trihydroxydammar-25-en-3-one (6), together with sixteen known compounds, chiefly from chloroform and ethyl acetate extracts. According to their structural characteristics, these compounds were divided into dammarane-type, oleanane- and ursane-type. Dammarane-type triterpenoids were isolated for the first time from the Juglans genus. As part of our continuing search for biologically active compounds from this plant, all of these compounds were also evaluated for their cytotoxic activities against the growth of human cancer cells lines HepG-2 by the MTT assay.
    CONCLUSIONS:
    The results were shown that 20(S)-protopanaxadiol, 2α,3β,23-trihydroxyolean-12-en-28-oic acid (2,3,23-Trihydroxy-12-oleanen-28-oic acid ) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibited better cytotoxicity in vitro with IC50 values of 10.32±1.13, 16.13±3.83, 15.97±2.47 μM, respectively. Preliminary structure-activity relationships for these compounds were discussed.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0462 mL 10.2312 mL 20.4625 mL 40.9249 mL 51.1561 mL
    5 mM 0.4092 mL 2.0462 mL 4.0925 mL 8.185 mL 10.2312 mL
    10 mM 0.2046 mL 1.0231 mL 2.0462 mL 4.0925 mL 5.1156 mL
    50 mM 0.0409 mL 0.2046 mL 0.4092 mL 0.8185 mL 1.0231 mL
    100 mM 0.0205 mL 0.1023 mL 0.2046 mL 0.4092 mL 0.5116 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    商陆皂苷元; Phytolaccagenin CFN99844 1802-12-6 C31H48O7 = 532.7 20mg QQ客服:2159513211
    远志酸; Polygalic acid CFN92195 1260-04-4 C29H44O6 = 488.7 20mg QQ客服:1413575084
    苜蓿酸; Medicagenic acid CFN93933 599-07-5 C30H46O6 = 502.68 5mg QQ客服:1413575084
    远志皂苷元; Senegenin CFN99109 2469-34-3 C30H45ClO6 = 537.14 20mg QQ客服:2159513211
    皂皮酸; Quillaic acid CFN96689 631-01-6 C30H46O5 = 486.69 5mg QQ客服:215959384
    3-beta-O-反式-对-香豆酰马期里酸; 3-beta-O-(trans-p-Coumaroyl)maslinic acid CFN92210 35482-91-8 C39H54O6 = 618.9 5mg QQ客服:215959384
    3-beta-O-顺式-对-香豆酰马期里酸; 3-beta-O-(cis-p-Coumaroyl)maslinic acid CFN92208 69297-40-1 C39H54O6 = 618.9 5mg QQ客服:2159513211
    Eucalyptolic acid; Eucalyptolic acid CFN92275 189272-68-2 C40H56O7 = 648.9 5mg QQ客服:3257982914
    脱氢山楂酸; Camaldulenic acid CFN96017 71850-15-2 C30H46O4 = 470.7 5mg QQ客服:2159513211
    阿江榄仁酸; Arjunic acid CFN98397 31298-06-3 C30H48O5 = 488.7 5mg QQ客服:1413575084

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