| Description: |
2β,3β,23α-Trihydroxy-12-oleanen-28-oic acid shows cytotoxic activities to human lung adenocarcinoma(A-549)cell lines. 2α,3β,23-Trihydroxyolean-12-en-28-oic acid and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibit cytotoxicity in vitro against the growth of human cancer cells lines HepG-2,with IC50 values of 16.13 ± 3.83, 15.97 ± 2.47 uM, respectively. |
| In vitro: |
| Lishizhen Medicine & Materia Medica Research, 2008,19(8):1931-2. | | Triterpenes from Glochidion coccineum and their Cytotoxicity in Vitro[Reference: WebLink] | To study the chemical constituents of Glochidion coccineum and their cytotoxicity in vitro.
METHODS AND RESULTS:
Various column chromatographic technologies were applied for isolation and purification and the structures were elucidated by spectral evidence.MTT method was applied to investigate their cytotoxic activities. Six compounds were isolated from the part of ethyl acetate and identified as Glochidiol ①,Lup-20(29)-ene-1α,23-diol ②,Glochidone ③,Epi-lupeol ④,3β,19α,23α-trihydroxy-12-oleanen-28-oic acid ⑤,2β,3β,23α-trihydroxy-12-oleanen-28-oic acid(2,3,23-Trihydroxy-12-oleanen-28-oic acid ) ⑥.
CONCLUSIONS:
The above compounds were obtained from this plant for the first time;compounds 1~4 showed cytotoxic activities to human hepatoma(BEL-7402),as well as compounds 5 and 6 to lung adenocarcinoma(A-549)cell lines. | | Molecules. 2015 Oct 22;20(10):19252-62. | | Cytotoxicity of Triterpenes from Green Walnut Husks of Juglans mandshurica Maxim in HepG-2 Cancer Cells.[Pubmed: 26506336 ] | Among the classes of identified natural products, triterpenoids, one of the largest families, have been studied extensively for their diverse structures and variety of biological activities, including antitumor effects.
METHODS AND RESULTS:
In the present study, a phytochemical study of the green walnut husks of Juglans mandshurica Maxim led to the isolation of a new dammarane triterpene, 12β, 20(R), 24(R)-trihydroxydammar-25-en-3-one (6), together with sixteen known compounds, chiefly from chloroform and ethyl acetate extracts. According to their structural characteristics, these compounds were divided into dammarane-type, oleanane- and ursane-type. Dammarane-type triterpenoids were isolated for the first time from the Juglans genus. As part of our continuing search for biologically active compounds from this plant, all of these compounds were also evaluated for their cytotoxic activities against the growth of human cancer cells lines HepG-2 by the MTT assay.
CONCLUSIONS:
The results were shown that 20(S)-protopanaxadiol, 2α,3β,23-trihydroxyolean-12-en-28-oic acid (2,3,23-Trihydroxy-12-oleanen-28-oic acid ) and 2α,3β,23-trihydroxyurs-12-en-28-oic acid exhibited better cytotoxicity in vitro with IC50 values of 10.32±1.13, 16.13±3.83, 15.97±2.47 μM, respectively. Preliminary structure-activity relationships for these compounds were discussed. |
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