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  • 15-羟基脱氢枞酸

    15-Hydroxydehydroabietic acid

    15-羟基脱氢枞酸
    产品编号 CFN98906
    CAS编号 54113-95-0
    分子式 = 分子量 C20H28O3 = 316.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The branches of Platycladus orientalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    15-羟基脱氢枞酸 CFN98906 54113-95-0 1mg QQ客服:1413575084
    15-羟基脱氢枞酸 CFN98906 54113-95-0 5mg QQ客服:1413575084
    15-羟基脱氢枞酸 CFN98906 54113-95-0 10mg QQ客服:1413575084
    15-羟基脱氢枞酸 CFN98906 54113-95-0 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • MTT Agrifood Research Finland (Finland)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Fribourg (Switzerland)
  • National Cancer Institute (USA)
  • University of Auckland (New Zealand)
  • Sapienza University of Rome (Italy)
  • Florida International University (USA)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Ain Shams University (Egypt)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Northeast Normal University Changchun (China)
  • University of Dicle (Turkey)
  • Calcutta University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int Immunopharmacol.2022, 106:108603.
  • Phytomedicine.2020, 79, 153351
  • Braz J Med Biol Res. 2016, 49(7)
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Cell Biochem Funct.2018, 36(6):303-311
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • Separations2023, 10(11), 567;
  • Compounds.2023, 3(1), 169-179.
  • Preprints2022, 202211.0388.v1.
  • GxABT2022, 2268.2:15515.
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • International J of Green Pharmacy2019, 13(3)
  • J Agric Food Chem.2016, 64(35):6783-90
  • Korean Herb. Med. Inf.2020, 8(2):205-213
  • Front. Plant Sci.2022, 13:757852.
  • Molecules.2020, 25(23):5609.
  • Front Pharmacol.2021, 12:764297.
  • Chem Biodivers.2023, 20(10):e202300741.
  • Sci Rep.2018, 8:15059
  • Nat Commun.2019, 10(1):2745
  • Nutr Cancer.2023, 75(1):376-387.
  • Pharmaceuticals (Basel).2020, 13(10):302.
  • Molecules2021, 26(1),230
  • ...
  • 生物活性
    Description: 15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities.
    Targets: Antifection | P450 (e.g. CYP17)
    In vitro:
    Chembiochem. 2013 Mar 4;14(4):467-73.
    Resin acid conversion with CYP105A1: an enzyme with potential for the production of pharmaceutically relevant diterpenoids.[Pubmed: 23371760]
    Cytochrome P450s are very versatile enzymes with great potential for biotechnological applications because of their ability to oxidize unactivated CH bonds.
    METHODS AND RESULTS:
    CYP105A1 from Streptomyces griseolus was first described as a herbicide-inducible sulfonylurea hydroxylase, but it is also able to convert other substrates such as vitamin D(3) . To extend the substrate pool of this interesting enzyme further, we screened a small diterpenoid compound library and were able to show the conversion of several resin acids. Binding of abietic acid, dehydroabietic acid, and isopimaric acid to the active site was assayed, and V(max) and K(m) values were calculated. The products were analyzed by NMR spectroscopy and identified as 15-hydroxyabietic acid, 15-hydroxydehydroabietic acid, and 15,16-epoxyisopimaric acid.
    CONCLUSIONS:
    As the observed products are difficult to obtain by chemical synthesis, CYP105A1 has proved to be a promising candidate for biotechnological applications that combine bioconversion and chemical synthesis to obtain functionalized resin acids.
    Am Ind Hyg Assoc J. 1998 Dec;59(12):889-94.
    Oxidized resin acids in aerosol derived from rosin core solder.[Pubmed: 9866169]
    Exposure to rosin during a variety of uses has been associated with dermal and pulmonary sensitization. Oxidized resin acids are present in many rosin products, and have been regarded as the main sensitizing rosin compounds in cases of dermal sensitization.
    METHODS AND RESULTS:
    This research describes oxidized resin acids identified in aerosol produced during soldering with rosin core solder. Oxidized resin acids found were 7-oxodehydroabietic acid, 15-hydroxydehydroabietic acid, and 7-hydroxydehydroabietic acid. The presence of oxidized compounds known to be dermal sensitizers in aerosol from rosin flux soldering supports the hypothesis that resin acid compounds are pulmonary sensitizers as previously proposed. Changes in the composition of resin acid aerosol derived from heated rosin core solder (compared with the parent material) are described.
    International Journal of Pharmacy & Pharmaceutical Sciences, 2014, 6(7): 375-8.
    Biotransformation of dehydroabietic acid with microbial cell cultures and α-glucosidase inhibitory activity of resulting metabolites[Reference: WebLink]
    Dehydroabietic acid (DHA, 1), a natural occurring diterpene resin acid, is an abundant resin acid in conifers, representing a natural wood protectant. The aim of this study was to use microbial cell cultures as tools for modification of 1 in order to obtain value-added functional derivatives.
    METHODS AND RESULTS:
    A scaled-up biotransformation of 1 by filamentous fungus Cunninghamella elegans, Rhizopus stolonifer, Gibberella fujikuroi, and Cephalosporium aphidicola were conducted for the first time. Three hydroxylated metabolites; 1Î2-hydroxydehydroabietic acid (2); 15-Hydroxydehydroabietic acid (3); and 16-hydroxy dehydroabietic acid (4). The structure of the hydroxylated metabolites were elucidated by 1-D (1H, 13C) and 2-D NMR (COSY, HMBC, HMQC, NOESY) techniques and MS analyses.
    CONCLUSIONS:
    Dehydroabietic acid (1) and their transformed products 2-4 exhibited a promising alpha-glucosidase inhibitory activity. Compound 1 showed 38 times more active than the standard alpha-glucosidase inhibitor, deoxynojirimycin. Compound 1 and its transformed metabolites 2-4 also showed significant antibacterial activities.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1606 mL 15.8028 mL 31.6056 mL 63.2111 mL 79.0139 mL
    5 mM 0.6321 mL 3.1606 mL 6.3211 mL 12.6422 mL 15.8028 mL
    10 mM 0.3161 mL 1.5803 mL 3.1606 mL 6.3211 mL 7.9014 mL
    50 mM 0.0632 mL 0.3161 mL 0.6321 mL 1.2642 mL 1.5803 mL
    100 mM 0.0316 mL 0.158 mL 0.3161 mL 0.6321 mL 0.7901 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    脱氢枞酸; 脱氢松香酸; Dehydroabietic acid CFN99822 1740-19-8 C20H28O2 = 300.4 20mg QQ客服:215959384
    7-氧代去氢松香酸; 7-Oxodehydroabietic acid CFN95411 18684-55-4 C20H26O3 = 314.4 5mg QQ客服:1457312923
    15-羟基脱氢枞酸; 15-Hydroxydehydroabietic acid CFN98906 54113-95-0 C20H28O3 = 316.4 5mg QQ客服:1457312923
    15-甲氧基二去氢松香酸; Abiesadine N CFN99263 1159913-80-0 C21H30O3 = 330.5 5mg QQ客服:1457312923
    7alpha,15-二羟基脱氢枞酸; 7alpha,15-Dihydroxydehydroabietic acid CFN89394 155205-64-4 C20H28O4 = 332.43 5mg QQ客服:1413575084
    15-羟基-7-氧代去氢松香酸; 15-Hydroxy-7-oxodehydroabietic acid CFN97533 95416-25-4 C20H26O4 = 330.4 5mg QQ客服:2056216494
    7,15-二羟基脱氢枞酸甲酯; Methyl 7,15-dihydroxydehydroabietate CFN99654 155205-65-5 C21H30O4 = 346.5 5mg QQ客服:3257982914
    7beta,15-二羟基脱氢枞酸甲酯; Methyl 7beta,15-dihydroxydehydroabietate CFN96967 107752-10-3 C21H30O4 = 346.46 5mg QQ客服:1413575084
    15-羟基-7-氧代去氢松香酸甲酯; Methyl 15-hydroxy-7-oxodehydroabietate CFN89396 60188-95-6 C21H28O4 = 344.44 5mg QQ客服:2056216494
    19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene; 19-O-beta-D-carboxyglucopyranosyl-12-O-beta-D-glucopyranosyl-11,16-dihydroxyabieta-8,11,13-triene CFN95217 1011714-20-7 C32H48O15 = 672.7 5mg QQ客服:2056216494

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