12-氧代四环香豆素A

12-Oxocalanolide A

	产品编号	CFN97812
	CAS编号	161753-49-7
	分子式 = 分子量	C₂₂H₂₄O₅ = 368.43
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Coumarins
	植物来源	The herbs of Calophyllum polyanthum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
12-氧代四环香豆素A	CFN97812	161753-49-7	1mg	QQ客服：2056216494
12-氧代四环香豆素A	CFN97812	161753-49-7	5mg	QQ客服：2056216494
12-氧代四环香豆素A	CFN97812	161753-49-7	10mg	QQ客服：2056216494
12-氧代四环香豆素A	CFN97812	161753-49-7	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
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PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
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PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Wollongong (Australia)

Wageningen University (Netherlands)

S.N.D.T. Women's University (India)

Lund University (Sweden)

University of Bonn (Germany)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

Utrecht University (Netherlands)

Subang Jaya Medical Centre (Malaysia)

Univerzita Karlova v Praze (Czech Republic)

Sanford Burnham Medical Research Institute (USA)

Medical University of Gdansk (Poland)

University of Sao Paulo (Brazil)

Georgia Institute of Technology (USA)

Ateneo de Manila University (Philippines)

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Description:

12-Oxocalanolide A is an inhibitor of HIV-1 reverse transcriptase (RT) and exhibits activity against a variety of viruse selected for resistance to other HIV-1 nonnucleoside RT inhibitors.

Targets:

HIV

In vitro:

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2179-84

In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.[Pubmed: 9873509]

METHODS AND RESULTS:
The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-Oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV).
CONCLUSIONS:
The compounds were determined to be inhibitors of HIV-1 reverse transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.

In vivo:

J Chromatogr B Biomed Sci Appl. 2000 Jun 9;742(2):267-75.

Quantification of (+)-calanolide A, a novel and naturally occurring anti-HIV agent, by high-performance liquid chromatography in plasma from rat, dog and human.[Pubmed: 10901131]

METHODS AND RESULTS:
A HPLC method was validated for quantification of (+)-calanolide A (1), a novel anti-HIV agent, in rat, dog and human plasma. The synthetic intermediate (+/-)-12-Oxocalanolide A (2) was found to be a suitable internal standard. Compounds were extracted from plasma using a solid-phase C(18) cartridge and quantified over the assay range of 12.5 to 800 ng/ml. The method was utilized to determine (+)-calanolide A pharmacokinetics in rats, dogs and humans. This is the first report of a validated HPLC assay for determination of (+)-calanolide A concentrations in rat and dog plasma as well as human plasma obtained from clinical trials.
CONCLUSIONS:
There was no evidence of in vivo epimerization of (+)-calanolide A to its inactive epimer (+)-calanolide B (3).

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
7-羟基-3-异戊烯基香豆素; 7-Hydroxy-3-prenylcoumarin	CFN97429	86654-26-4	C₁₄H₁₄O₃ = 230.3	5mg	QQ客服：3257982914
7-羟基-6-甲氧基-3-异戊烯基香豆素; 7-Hydroxy-6-methoxy-3-prenylcoumarin	CFN98374	299159-90-3	C₁₅H₁₆O₄ = 260.3	5mg	QQ客服：215959384
3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin; 3-(1,1-Dimethylallyl)-8-hydroxy-7-methoxycoumarin	CFN89287	61899-42-1	C₁₅H₁₆O₄ = 260.28	5mg	QQ客服：1413575084
状芸香素 ; Chalepensin	CFN89033	13164-03-9	C₁₆H₁₄O₃ = 254.28	5mg	QQ客服：1413575084
芸香内酯; Rutamarin	CFN89223	14882-94-1	C₂₁H₂₄O₅ = 356.41	5mg	QQ客服：1413575084
三叉苦甲素; Evodosin A	CFN89021	1291053-38-7	C₁₄H₁₆O₆ = 280.27	5mg	QQ客服：1457312923
12-氧代四环香豆素A; 12-Oxocalanolide A	CFN97812	161753-49-7	C₂₂H₂₄O₅ = 368.43	5mg	QQ客服：2159513211
胡桐素E; Calanolide E	CFN99466	142566-61-8	C₂₂H₂₈O₆ = 388.5	5mg	QQ客服：1457312923
7-氨基-4-甲基-3-香豆素醋酸; 7-Amino-4-methylcoumarin	CFN90420	106562-32-7	C₁₂H₁₁NO₄ = 233.22	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7142 mL	13.5711 mL	27.1422 mL	54.2844 mL	67.8555 mL
5 mM	0.5428 mL	2.7142 mL	5.4284 mL	10.8569 mL	13.5711 mL
10 mM	0.2714 mL	1.3571 mL	2.7142 mL	5.4284 mL	6.7855 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	1.0857 mL	1.3571 mL
100 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.5428 mL	0.6786 mL