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  • 1-脱氢-10-姜酮

    • 1-脱氢-10-姜酮

    1-Dehydro-10-gingerdione

    1-脱氢-10-姜酮
    		产品编号 CFN92374
    CAS编号 136826-50-1
    分子式 = 分子量 C21H30O4 = 346.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Zingber officinale Rosc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1-脱氢-10-姜酮 CFN92374 136826-50-1 1mg QQ客服：1413575084
    1-脱氢-10-姜酮 CFN92374 136826-50-1 5mg QQ客服：1413575084
    1-脱氢-10-姜酮 CFN92374 136826-50-1 10mg QQ客服：1413575084
    1-脱氢-10-姜酮 CFN92374 136826-50-1 20mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • Oxid Med Cell Longev.2022, 2022:9139338.
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  • Molecules.2019, 25(1):E103
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  • Front Plant Sci.2020, 10:1705
  • ...
    • 生物活性
    Description: 1-Dehydro-10-gingerdione has anti-inflammatory action, the molecular target is Myeloid differentiation protein; it involves in the suppression of NF-κB-regulated gene expression in LPS-activated macrophages, has therapeutic potential in NF-κB-associated inflammation and autoimmune disorders.
    Targets: NF-kB | TLR | IkB | TNF-α | NOS | COX | IL Receptor | AP-1 | IFN-γ | IKK
    In vitro:
    Br J Pharmacol. 2012 Sep;167(1):128-40.
    1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes.[Pubmed: 22489648]
    Pungent constituents of ginger (Zingiber officinale) have beneficial effects on inflammatory pain and arthritic swelling. However, the molecular basis for these pharmacological properties is only partially understood. Here, we investigated the molecular target of 1-Dehydro-10-gingerdione (D10G), one of the pungent constituents of ginger, that mediates its suppression of NF-κB-regulated expression of inflammatory genes linked to toll-like receptor (TLR)-mediated innate immunity.
    METHODS AND RESULTS:
    RAW 264.7 macrophages or primary macrophages-derived from bone marrows of C57BL/6 or C3H/HeJ mice were stimulated with the TLR4 agonist LPS in the presence of 1-Dehydro-10-gingerdione. Catalytic activity of inhibitory κB (IκB) kinase β (IKKβ) was determined by a kinase assay and immunoblot analysis, and the expression of inflammatory genes by RT-PCR analysis and a promoter-dependent reporter assay. 1-Dehydro-10-gingerdione directly inhibited the catalytic activity of cell-free IKKβ. Moreover, 1-Dehydro-10-gingerdione irreversibly inhibited cytoplasmic IKKβ-catalysed IκBα phosphorylation in macrophages activated by TLR agonists or TNF-α, and also IKKβ vector-elicited NF-κB transcriptional activity in these cells. These effects of 1-Dehydro-10-gingerdione were abolished by substitution of the Cys(179) with Ala in the activation loop of IKKβ, indicating a direct interacting site of 1-Dehydro-10-gingerdione. This mechanism was shown to mediate 1-Dehydro-10-gingerdione-induced disruption of NF-κB activation in LPS-stimulated macrophages and the suppression of NF-κB-regulated gene expression of inducible NOS, COX-2 and IL-6.
    CONCLUSIONS:
    This study demonstrates that IKKβ is a molecular target of 1-Dehydro-10-gingerdione involved in the suppression of NF-κB-regulated gene expression in LPS-activated macrophages; this suggests 1-Dehydro-10-gingerdione has therapeutic potential in NF-κB-associated inflammation and autoimmune disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.886 mL 14.43 mL 28.86 mL 57.7201 mL 72.1501 mL
    5 mM 0.5772 mL 2.886 mL 5.772 mL 11.544 mL 14.43 mL
    10 mM 0.2886 mL 1.443 mL 2.886 mL 5.772 mL 7.215 mL
    50 mM 0.0577 mL 0.2886 mL 0.5772 mL 1.1544 mL 1.443 mL
    100 mM 0.0289 mL 0.1443 mL 0.2886 mL 0.5772 mL 0.7215 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二乙酰氧基-4-姜二醇; Diacetoxy-4-gingerdiol CFN92373 863780-88-5 C19H28O6 = 352.4 5mg QQ客服：1413575084
    甲基 二乙酰氧基-6-姜二醇; Methyl diacetoxy-6-gingerdiol CFN92301 863780-90-9 C22H34O6 = 394.5 5mg QQ客服：3257982914
    1-脱氢-6-姜酮; 1-Dehydro-6-gingerdione CFN92298 76060-35-0 C17H22O4 = 290.4 10mg QQ客服：3257982914
    6-姜烯酚; 6-Shogaol CFN99531 555-66-8 C17H24O3 = 276.37 20mg QQ客服：1457312923
    二乙酰氧基-6-姜二醇; Diacetoxy-6-gingerdiol CFN92375 143615-75-2 C21H32O6 = 380.5 5mg QQ客服：1413575084
    二氢非洲豆蔻醇; Dihydroparadol CFN91532 143111-84-6 C17H28O3 = 280.4 10mg QQ客服：1413575084
    非洲豆蔻醇; Paradol CFN91045 27113-22-0 C17H26O3 = 278.39 10mg QQ客服：1457312923
    (E)-[6]-去氢非洲豆蔻醇; (E)-[6]-Dehydroparadol CFN91531 878006-06-5 C17H24O3 = 276.4 5mg QQ客服：2159513211
    8-姜烯酚; 8-Shogaol CFN92299 36700-45-5 C19H28O3 = 304.4 20mg QQ客服：215959384
    10-姜烯酚; 10-Shogaol CFN92300 36752-54-2 C21H32O3 = 332.5 20mg QQ客服：2056216494

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