1-脱氢-10-姜酮

1-Dehydro-10-gingerdione

	产品编号	CFN92374
	CAS编号	136826-50-1
	分子式 = 分子量	C₂₁H₃₀O₄ = 346.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The rhizomes of Zingber officinale Rosc.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
1-脱氢-10-姜酮	CFN92374	136826-50-1	1mg	QQ客服：1413575084
1-脱氢-10-姜酮	CFN92374	136826-50-1	5mg	QQ客服：1413575084
1-脱氢-10-姜酮	CFN92374	136826-50-1	10mg	QQ客服：1413575084
1-脱氢-10-姜酮	CFN92374	136826-50-1	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Worcester Polytechnic Institute (USA)

University of Malaya (Malaysia)

Universidad de Ciencias y Artes de Chiapas (Mexico)

Universite de Lille1 (France)

Siksha O Anusandhan University (India)

University of Wuerzburg (Germany)

Kazusa DNA Research Institute (Japan)

University of Maryland School of Medicine (USA)

University of Toronto (Canada)

Utrecht University (Netherlands)

Northeast Normal University Changchun (China)

Charles Sturt University (Denmark)

Istanbul University (Turkey)

Julius Kühn-Institut (Germany)

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Description:

1-Dehydro-10-gingerdione has anti-inflammatory action, the molecular target is Myeloid differentiation protein; it involves in the suppression of NF-κB-regulated gene expression in LPS-activated macrophages, has therapeutic potential in NF-κB-associated inflammation and autoimmune disorders.

Targets:

NF-kB | TLR | IkB | TNF-α | NOS | COX | IL Receptor | AP-1 | IFN-γ | IKK

In vitro:

Br J Pharmacol. 2012 Sep;167(1):128-40.

1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes.[Pubmed: 22489648]

Pungent constituents of ginger (Zingiber officinale) have beneficial effects on inflammatory pain and arthritic swelling. However, the molecular basis for these pharmacological properties is only partially understood. Here, we investigated the molecular target of 1-Dehydro-10-gingerdione (D10G), one of the pungent constituents of ginger, that mediates its suppression of NF-κB-regulated expression of inflammatory genes linked to toll-like receptor (TLR)-mediated innate immunity.
METHODS AND RESULTS:
RAW 264.7 macrophages or primary macrophages-derived from bone marrows of C57BL/6 or C3H/HeJ mice were stimulated with the TLR4 agonist LPS in the presence of 1-Dehydro-10-gingerdione. Catalytic activity of inhibitory κB (IκB) kinase β (IKKβ) was determined by a kinase assay and immunoblot analysis, and the expression of inflammatory genes by RT-PCR analysis and a promoter-dependent reporter assay. 1-Dehydro-10-gingerdione directly inhibited the catalytic activity of cell-free IKKβ. Moreover, 1-Dehydro-10-gingerdione irreversibly inhibited cytoplasmic IKKβ-catalysed IκBα phosphorylation in macrophages activated by TLR agonists or TNF-α, and also IKKβ vector-elicited NF-κB transcriptional activity in these cells. These effects of 1-Dehydro-10-gingerdione were abolished by substitution of the Cys(179) with Ala in the activation loop of IKKβ, indicating a direct interacting site of 1-Dehydro-10-gingerdione. This mechanism was shown to mediate 1-Dehydro-10-gingerdione-induced disruption of NF-κB activation in LPS-stimulated macrophages and the suppression of NF-κB-regulated gene expression of inducible NOS, COX-2 and IL-6.
CONCLUSIONS:
This study demonstrates that IKKβ is a molecular target of 1-Dehydro-10-gingerdione involved in the suppression of NF-κB-regulated gene expression in LPS-activated macrophages; this suggests 1-Dehydro-10-gingerdione has therapeutic potential in NF-κB-associated inflammation and autoimmune disorders.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
二氢非洲豆蔻醇; Dihydroparadol	CFN91532	143111-84-6	C₁₇H₂₈O₃ = 280.4	10mg	QQ客服：2056216494
非洲豆蔻醇; Paradol	CFN91045	27113-22-0	C₁₇H₂₆O₃ = 278.39	10mg	QQ客服：2159513211
(E)-[6]-去氢非洲豆蔻醇; (E)-[6]-Dehydroparadol	CFN91531	878006-06-5	C₁₇H₂₄O₃ = 276.4	5mg	QQ客服：2159513211
8-姜烯酚; 8-Shogaol	CFN92299	36700-45-5	C₁₉H₂₈O₃ = 304.4	20mg	QQ客服：2056216494
10-姜烯酚; 10-Shogaol	CFN92300	36752-54-2	C₂₁H₃₂O₃ = 332.5	20mg	QQ客服：3257982914
(3S,5S)-[6]-姜二醇; (3S,5S)-[6]-Gingerdiol	CFN95838	143615-76-3	C₁₇H₂₈O₄ = 296.4	5mg	QQ客服：1457312923
6-姜酚; 6-Gingerol	CFN99931	23513-14-6	C₁₇H₂₆O₄ = 294.4	20mg	QQ客服：1413575084
甲基-6-姜辣素; Methyl-6-gingerol	CFN95833	23513-10-2	C₁₈H₂₈O₄ = 308.4	20mg	QQ客服：2056216494
8-姜酚; 8-Gingerol	CFN99131	23513-08-8	C₁₉H₃₀O₄ = 322.44	20mg	QQ客服：3257982914
10-姜酚; 10-Gingerol	CFN99132	23513-15-7	C₂₁H₃₄O₄ = 350.49	20mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.886 mL	14.43 mL	28.86 mL	57.7201 mL	72.1501 mL
5 mM	0.5772 mL	2.886 mL	5.772 mL	11.544 mL	14.43 mL
10 mM	0.2886 mL	1.443 mL	2.886 mL	5.772 mL	7.215 mL
50 mM	0.0577 mL	0.2886 mL	0.5772 mL	1.1544 mL	1.443 mL
100 mM	0.0289 mL	0.1443 mL	0.2886 mL	0.5772 mL	0.7215 mL