
1-脱氢-10-姜酮
1-Dehydro-10-gingerdione
|
产品编号 |
CFN92374 |
CAS编号 |
136826-50-1 |
分子式 = 分子量 |
C21H30O4 = 346.5 |
产品纯度 |
>=98% |
物理属性 |
Powder |
化合物类型 |
Phenols |
植物来源 |
The rhizomes of Zingber officinale Rosc. |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
1-脱氢-10-姜酮 |
CFN92374 |
136826-50-1 |
1mg |
QQ客服:1413575084 |
1-脱氢-10-姜酮 |
CFN92374 |
136826-50-1 |
5mg |
QQ客服:1413575084 |
1-脱氢-10-姜酮 |
CFN92374 |
136826-50-1 |
10mg |
QQ客服:1413575084 |
1-脱氢-10-姜酮 |
CFN92374 |
136826-50-1 |
20mg |
QQ客服:1413575084 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
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Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
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ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
Kyung Hee University (Korea)
Mendel University in Brno (Czech Republic)
Center for protein Engineering (CIP) (Belgium)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Sanford Burnham Prebys Medical Discovery Institute (USA)
Universit?t Basel (Switzerland)
University of Hawaii Cancer Center (USA)
S.N.D.T. Women's University (India)
Macau University of Science and Technology (China)
University of Padjajaran (Indonesia)
University of East Anglia (United Kingdom)
Seoul National University of Science and Technology (Korea)
Universiti Kebangsaan Malaysia (Malaysia)
Periyar University (India)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
1-Dehydro-10-gingerdione has anti-inflammatory action, the molecular target is Myeloid differentiation protein; it involves in the suppression of NF-κB-regulated gene expression in LPS-activated macrophages, has therapeutic potential in NF-κB-associated inflammation and autoimmune disorders. |
Targets: |
NF-kB | TLR | IkB | TNF-α | NOS | COX | IL Receptor | AP-1 | IFN-γ | IKK |
In vitro: |
Br J Pharmacol. 2012 Sep;167(1):128-40. | 1-Dehydro-[10]-gingerdione from ginger inhibits IKKβ activity for NF-κB activation and suppresses NF-κB-regulated expression of inflammatory genes.[Pubmed: 22489648] | Pungent constituents of ginger (Zingiber officinale) have beneficial effects on inflammatory pain and arthritic swelling. However, the molecular basis for these pharmacological properties is only partially understood. Here, we investigated the molecular target of 1-Dehydro-10-gingerdione (D10G), one of the pungent constituents of ginger, that mediates its suppression of NF-κB-regulated expression of inflammatory genes linked to toll-like receptor (TLR)-mediated innate immunity. METHODS AND RESULTS: RAW 264.7 macrophages or primary macrophages-derived from bone marrows of C57BL/6 or C3H/HeJ mice were stimulated with the TLR4 agonist LPS in the presence of 1-Dehydro-10-gingerdione. Catalytic activity of inhibitory κB (IκB) kinase β (IKKβ) was determined by a kinase assay and immunoblot analysis, and the expression of inflammatory genes by RT-PCR analysis and a promoter-dependent reporter assay. 1-Dehydro-10-gingerdione directly inhibited the catalytic activity of cell-free IKKβ. Moreover, 1-Dehydro-10-gingerdione irreversibly inhibited cytoplasmic IKKβ-catalysed IκBα phosphorylation in macrophages activated by TLR agonists or TNF-α, and also IKKβ vector-elicited NF-κB transcriptional activity in these cells. These effects of 1-Dehydro-10-gingerdione were abolished by substitution of the Cys(179) with Ala in the activation loop of IKKβ, indicating a direct interacting site of 1-Dehydro-10-gingerdione. This mechanism was shown to mediate 1-Dehydro-10-gingerdione-induced disruption of NF-κB activation in LPS-stimulated macrophages and the suppression of NF-κB-regulated gene expression of inducible NOS, COX-2 and IL-6. CONCLUSIONS: This study demonstrates that IKKβ is a molecular target of 1-Dehydro-10-gingerdione involved in the suppression of NF-κB-regulated gene expression in LPS-activated macrophages; this suggests 1-Dehydro-10-gingerdione has therapeutic potential in NF-κB-associated inflammation and autoimmune disorders. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
2.886 mL |
14.43 mL |
28.86 mL |
57.7201 mL |
72.1501 mL |
5 mM |
0.5772 mL |
2.886 mL |
5.772 mL |
11.544 mL |
14.43 mL |
10 mM |
0.2886 mL |
1.443 mL |
2.886 mL |
5.772 mL |
7.215 mL |
50 mM |
0.0577 mL |
0.2886 mL |
0.5772 mL |
1.1544 mL |
1.443 mL |
100 mM |
0.0289 mL |
0.1443 mL |
0.2886 mL |
0.5772 mL |
0.7215 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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