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  • 蓬莪术环氧酮

    Zederone

    蓬莪术环氧酮
    产品编号 CFN92616
    CAS编号 7727-79-9
    分子式 = 分子量 C15H18O3 = 246.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma zedoaria
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蓬莪术环氧酮 CFN92616 7727-79-9 10mg QQ客服:215959384
    蓬莪术环氧酮 CFN92616 7727-79-9 20mg QQ客服:215959384
    蓬莪术环氧酮 CFN92616 7727-79-9 50mg QQ客服:215959384
    蓬莪术环氧酮 CFN92616 7727-79-9 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Goias (UFG) (Brazil)
  • University of Pretoria (South Africa)
  • University of Canterbury (New Zealand)
  • Osmania University (India)
  • University Medical Center Mainz (Germany)
  • University of Maryland School of Medicine (USA)
  • Aarhus University (Denmark)
  • University of Limpopo (South Africa)
  • University of South Australia (Australia)
  • Istanbul University (Turkey)
  • Universidad Industrial de Santander (Colombia)
  • Yale University (USA)
  • Mendel University in Brno (Czech Republic)
  • Monash University Malaysia (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Exp Parasitol.2015, 153:160-4
  • Acta Biochim Pol.2015, 62(2):253-8
  • Mediators Inflamm.2016, 2016:7216912
  • Nat Prod Sci.2016, 22(2)
  • Nat Prod Commun.2017, 12(5):771-778
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Preprints2017, 2017120176
  • Front Pharmacol.2017, 8:205
  • Sci Rep. 2018, 10590
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Molecules.2018, 23(3):E615
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • J Sep Sci.2018, 41(11):2488-2497
  • Eur J Pharmacol.2018, 832:96-103
  • Chemistry of Plant Materials.2019, 129-136
  • J Pharm Biomed Anal.2019, 172:268-277
  • Int J Mol Sci.2019, 20(9):E2244
  • J Ethnopharmacol.2019, 236:31-41
  • J Nat Prod.2019, 82(4):1002-1008
  • Planta Med.2019, 85(4):347-355
  • Saudi Pharm J2020, 10.1016
  • Antioxidants (Basel).2020, 9(2): E119
  • Cell Metab.2020, S1550-4131(20)30002-4
  • ...
  • 生物活性
    Description: Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries.
    Targets: TNF-α | Nrf2 | NADPH-oxidase | P450 (e.g. CYP17) | Antifection
    In vivo:
    Int J Toxicol. 2013 Nov-Dec;32(6):454-62.
    Zederone, a sesquiterpene from Curcuma elata Roxb, is hepatotoxic in mice.[Pubmed: 24082031]
    The present study aimed to investigate the hepatotoxicity of Zederone isolated from Curcuma elata in mice.
    METHODS AND RESULTS:
    Adult male mice were intraperitoneally injected with a single dose of Zederone (50-300 mg/kg body weight [BW]). Twenty-four hours after the injection, Zederone induced liver enlargement with scattered white foci over the organ. The medium lethal dose (LD₅₀) value at 24 hours of Zederone was approximately 223 mg/kg BW. Hepatic centrilobular necrosis with marked increases in plasma alanine transaminase activity and total bilirubin levels was observed. Zederone at a dose of 200 mg/kg BW markedly decreased the activity of superoxide dismutase and the hepatic glutathione content, whereas the activity of catalase was not altered. The compound at this dose also increased the messenger RNA (mRNA) expression of Cyp2b10 and Cyp3a11, which are the main drug-metabolizing enzymes in the liver. The mRNA expression of proinflammatory cytokine tumor necrosis factor α was increased. The nuclear factor-E2-related factor 2 protein, which is the transcription factor regulating the antioxidant gene expression, was decreased.
    CONCLUSIONS:
    The histopathology of massive hepatic centrilobular necrosis with an increase in the expression of cytochrome P450 (Cyp) suggests that the possible potentiation of Zederone-induced hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that cause the oxidative stress and liver cell injuries.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0601 mL 20.3004 mL 40.6009 mL 81.2018 mL 101.5022 mL
    5 mM 0.812 mL 4.0601 mL 8.1202 mL 16.2404 mL 20.3004 mL
    10 mM 0.406 mL 2.03 mL 4.0601 mL 8.1202 mL 10.1502 mL
    50 mM 0.0812 mL 0.406 mL 0.812 mL 1.624 mL 2.03 mL
    100 mM 0.0406 mL 0.203 mL 0.406 mL 0.812 mL 1.015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    焦蓬莪术酮; Pyrocurzerenone CFN96169 20013-75-6 C15H16O = 212.3 20mg QQ客服:3257982914
    Dehydrochromolaenin; Dehydrochromolaenin CFN96174 20013-76-7 C15H14O = 210.3 5mg QQ客服:2159513211
    2-Methoxyfuranoguaia-9-ene-8-one; 2-Methoxyfuranoguaia-9-ene-8-one CFN95220 88010-62-2 C16H20O3 = 260.3 10mg QQ客服:215959384
    2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one; 2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one CFN95197 1809980-25-3 C18H24O5 = 320.4 10mg QQ客服:3257982914
    异莪术呋喃二烯; Isofuranodiene CFN98971 57566-47-9 C15H20O = 216.3 5mg QQ客服:3257982914
    莪术呋喃二烯酮; Furanodienone CFN92028 24268-41-5 C15H18O2 = 230.3 20mg QQ客服:1413575084
    蓬莪术环氧酮; Zederone CFN92616 7727-79-9 C15H18O3 = 246.3 20mg QQ客服:215959384
    钓樟内酯; Linderalactone CFN99761 728-61-0 C15H16O3 = 244.29 20mg QQ客服:1148253675
    1,2-环氧-10(14)-呋喃吉玛烯-6-酮; 1,2-Epoxy-10(14)-furanogermacren-6-one CFN95214 383368-24-9 C15H18O3 = 246.3 10mg QQ客服:2932563308
    (1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one; (1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one CFN95219 1393342-06-7 C16H20O3 = 260.3 5mg QQ客服:215959384

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