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  • 莪术呋喃二烯酮

    Furanodienone

    莪术呋喃二烯酮
    产品编号 CFN92028
    CAS编号 24268-41-5
    分子式 = 分子量 C15H18O2 = 230.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes of Curcuma zedoaria.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    莪术呋喃二烯酮 CFN92028 24268-41-5 10mg QQ客服:215959384
    莪术呋喃二烯酮 CFN92028 24268-41-5 20mg QQ客服:215959384
    莪术呋喃二烯酮 CFN92028 24268-41-5 50mg QQ客服:215959384
    莪术呋喃二烯酮 CFN92028 24268-41-5 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas islam negeri Jakarta (Indonesia)
  • Melbourne University (Australia)
  • Julius Kühn-Institut (Germany)
  • Worcester Polytechnic Institute (USA)
  • Universidad Industrial de Santander (Colombia)
  • Pennsylvania State University (USA)
  • University of Cincinnati (USA)
  • Calcutta University (India)
  • Complutense University of Madrid (Spain)
  • Medizinische Universit?t Wien (Austria)
  • University of Maryland (USA)
  • Semmelweis Unicersity (Hungary)
  • University Medical Center Mainz (Germany)
  • University of Liège (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Journal of Pharmacognosy2014, 113-120
  • Pharmacogn Mag.2015, 11:S585-91
  • Tumour Biol.2015, 36(9):7027-34
  • Acta Biochim Pol.2015, 62(2):253-8
  • Analytical sci. & Tech2016, 186-193
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Acta Chromatographica2016, 29(3)
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • J Ethnopharmacol.2017, 206:73-77
  • Food Chem.2017, 228:301-314
  • Oncotarget.2017, 9(3):4161-4172
  • Molecules.2018, 23(3):E615
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Biomol Ther (Seoul).2019, 10.4062
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Cancer Manag Res.2019, 11:483-500
  • J Ethnopharmacol.2019, 235:406-414
  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Pest Manag Sci.2019, 75(9):2530-2541
  • Sci Rep.2019, 9(1):6429
  • Pharmacological Reports2020, 1-9
  • United States Patent Application2020, 20200038363
  • J Nat Med.2020, 74(1):65-75
  • ...
  • 生物活性
    Description: Furanodienone inhibits EGFR/HER2 signaling pathway in BT474 and SKBR3 cells, the effect is specifically dependent on the expression of HER2 but not EGFR; it also has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling.
    Targets: EGFR | HER2 | GSK-3 | Akt | p27 | Estrogen receptor | c-Myc | Progestogen receptor
    In vitro:
    Cancer Chemother Pharmacol. 2011 Nov;68(5):1315-23.
    Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells.[Pubmed: 21461888]
    Overexpression of EGFR and HER2 is seen in breast cancers and results in poor prognosis and decreased patient survival. Clinically, EGFR and HER2 are effective therapeutic targets. The objective of this study is to investigate the in vitro effects of Furanodienone, an active chemical component isolated from Rhizoma Curcumae, on the activation of EGFR/HER2 signaling, cell cycle, and apoptosis in HER2-overexpressing BT474 and SKBR3 cells.
    METHODS AND RESULTS:
    Cell growth was assessed by SRB protein assay. Cell cycle analysis was carried out by flow cytometry, and apoptosis was observed by Annexin V and DAPI staining. Effects of Furanodienone on the activation of EGFR/HER2 signaling-related proteins were analyzed by western blotting. RESULTS: Furanodienone inhibited cell growth in BT474 and SKBR3 cells. Furanodienone caused G1 arrest in BT474 cells and induced apoptosis in SKBR3 cells. Furanodienone interfered with EGFR/HER2 signaling in treated cells as shown by decreases in phosphorylated EGFR, HER2, Akt, Gsk3β and an increase in p27(kip1) protein. Accordingly, Furanodienone inhibited EGF-induced phosphorylation of EGFR, HER2, Akt, and Gsk3β. EGFR-specific siRNA knockdown did not affect the cell growth inhibitory effect of Furanodienone. On the contrary, specific siRNA knockdown of HER2 increased cellular resistance to Furanodienone toxicity. In HER-2-deficient MDA-MB-231 cells, the transfection and expression of HER2 increased the sensitivity of cells to Furanodienone toxicity.
    CONCLUSIONS:
    Furanodienone inhibited EGFR/HER2 signaling pathway in BT474 and SKBR3 cells. More importantly, the effect of Furanodienone was specifically dependent on HER2, but not EGFR, expression.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.3422 mL 21.7108 mL 43.4216 mL 86.8432 mL 108.5541 mL
    5 mM 0.8684 mL 4.3422 mL 8.6843 mL 17.3686 mL 21.7108 mL
    10 mM 0.4342 mL 2.1711 mL 4.3422 mL 8.6843 mL 10.8554 mL
    50 mM 0.0868 mL 0.4342 mL 0.8684 mL 1.7369 mL 2.1711 mL
    100 mM 0.0434 mL 0.2171 mL 0.4342 mL 0.8684 mL 1.0855 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one; 2-Methoxy-5-acetoxy-furanogermacr-1(10)-en-6-one CFN95197 1809980-25-3 C18H24O5 = 320.4 10mg QQ客服:2932563308
    异莪术呋喃二烯; Isofuranodiene CFN98971 57566-47-9 C15H20O = 216.3 5mg QQ客服:1148253675
    莪术呋喃二烯酮; Furanodienone CFN92028 24268-41-5 C15H18O2 = 230.3 20mg QQ客服:1413575084
    蓬莪术环氧酮; Zederone CFN92616 7727-79-9 C15H18O3 = 246.3 20mg QQ客服:1148253675
    钓樟内酯; Linderalactone CFN99761 728-61-0 C15H16O3 = 244.29 20mg QQ客服:3257982914
    1,2-环氧-10(14)-呋喃吉玛烯-6-酮; 1,2-Epoxy-10(14)-furanogermacren-6-one CFN95214 383368-24-9 C15H18O3 = 246.3 10mg QQ客服:2159513211
    (1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one; (1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one CFN95219 1393342-06-7 C16H20O3 = 260.3 5mg QQ客服:2932563308
    乌药醚内酯; Linderane CFN98175 13476-25-0 C15H16O4 = 260.28 20mg QQ客服:2932563308
    伪新乌药醚内酯; Pseudoneolinderane CFN91936 20082-45-5 C15H16O4 = 260.29 5mg QQ客服:1148253675
    二氢焦蓬莪术酮; Dihydropyrocurzerenone CFN91911 59462-26-9 C15H18O = 214.30 5mg QQ客服:1413575084

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