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  • 异莪术呋喃二烯

    Isofuranodiene

    异莪术呋喃二烯
    产品编号 CFN98971
    CAS编号 57566-47-9
    分子式 = 分子量 C15H20O = 216.3
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Chloranthus spicatus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异莪术呋喃二烯 CFN98971 57566-47-9 1mg QQ客服:2932563308
    异莪术呋喃二烯 CFN98971 57566-47-9 5mg QQ客服:2932563308
    异莪术呋喃二烯 CFN98971 57566-47-9 10mg QQ客服:2932563308
    异莪术呋喃二烯 CFN98971 57566-47-9 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Bonn (Germany)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Nanjing University of Chinese Medicine (China)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Technical University of Denmark (Denmark)
  • University of Cincinnati (USA)
  • University of Pretoria (South Africa)
  • Universidad de La Salle (Mexico)
  • John Innes Centre (United Kingdom)
  • Ateneo de Manila University (Philippines)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Zurich (Switzerland)
  • Melbourne University (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Acta Biochim Pol.2015, 62(2):253-8
  • Phytomedicine.2016, 23(4):331-9
  • HortTechnology2016, 26(6):816-819
  • J Agric Food Chem.2016, 64(35):6783-90
  • Plant Methods.2017, 13:108
  • International. J. of Food Properties 2017, 20:S131-S140
  • Srinagarind Medical Journal2017, 32(1)
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Pharm Biol.2017, 55(1):360-366
  • Sci Rep.2017, 7:46299
  • Mol Pharm.2018, 15(8):3285-3296
  • Anat Rec2018, 24264
  • Food Chem.2018, 262:78-85
  • Primary and Industrial.2018, 52(11)
  • Journal of Life Science2018, 917-922
  • World J Mens Health.2019, 10.5534
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Enzyme Microb Technol.2019, 122:64-73
  • Chemistry of Plant Materials.2019, 129-136
  • Front Neurosci.2019, 13:1091
  • Molecules.2019, 24(17):E3127
  • Nat Prod Sci.2019, 25(3):238
  • Evid-Based Compl Alt2020, 7202519:13
  • ...
  • 生物活性
    Description: Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting the proliferation and inducing apoptosis in cancer cells; it can induce apoptosis in colon cancer cells in a time and concentration-dependent manner suggesting a potential role as models for the development of chemopreventive agents. Isofuranodiene at concentrations of 25 and 12.5 lM alone, or in combination with 50 nM nerve growth factor (NGF) , shows a marked stimulation of neuritogenesis,which appears to be a promising neurotrophic and neuroprotective agent.
    Targets: IL Receptor | NOS | NGF
    In vitro:
    ScientificWorldJournal. 2014;2014:264829.
    Antiproliferative evaluation of isofuranodiene on breast and prostate cancer cell lines.[Pubmed: 24967427]

    METHODS AND RESULTS:
    The anticancer activity of Isofuranodiene, extracted from Smyrnium olusatrum, was evaluated in human breast adenocarcinomas MDA-MB 231 and BT 474, and Caucasian prostate adenocarcinoma PC 3 cell lines by MTS assay. MTS assay showed a dose-dependent growth inhibition in the tumor cell lines after Isofuranodiene treatment. The best antiproliferative activity of the Isofuranodiene was found on PC 3 cells with an IC50 value of 29 μM, which was slightly less than the inhibition against the two breast adenocarcinoma cell lines with IC50 values of 59 and 55 μM on MDA-MB 231 and BT 474, respectively. Hoechst 33258 assay was performed in order to study the growth inhibition mechanism in prostate cancer cell line; the results indicate that Isofuranodiene induces apoptosis.
    CONCLUSIONS:
    Overall, the understudy compound has a good anticancer activity especially towards the PC 3. On the contrary, it is less active on Chinese hamster ovary cells (CHO) and human embryonic kidney (HEK 293) appearing as a good candidate as a potential natural anticancer drug with low side effects.
    Food Chem. 2016 Feb 1;192:782-7.
    Isofuranodiene: A neuritogenic compound isolated from wild celery (Smyrnium olusatrum L., Apiaceae).[Pubmed: 26304411]
    In the search for neuroactive compounds that mimic the nerve growth factor (NGF) activity for the protection against neurodegenerative diseases, the potential medicinal values of foods and plants attracts intense interest. Isofuranodiene is the major constituent of the essential oil of wild celery (Smyrnium olusatrum L., Apiaceae).
    METHODS AND RESULTS:
    The cytotoxic effects of Isofuranodiene towards rat neuronal PC-12 pheochromocytoma cells were determined by MTT assay, while the cell differentiation was evaluated with xCELLigence real time cell analysis system (RTCA DP), and the neuritogenic activity was assessed by neurite outgrowth image analysis. Isofuranodiene at concentrations of 25 and 12.5 μM alone, or in combination with 50 nM NGF, showed a marked stimulation of neuritogenesis, but it was more effective at 12.5 μM with or without NGF.
    CONCLUSIONS:
    The present study reports the first evidence of the neuritogenic effects of Isofuranodiene, which appears to be a promising neurotrophic and neuroprotective agent deserving further investigation.
    In vivo:
    Nat Prod Res. 2015 May 15:1-4.
    Isofuranodiene, the main volatile constituent of wild celery (Smyrnium olusatrum L.), protects d-galactosamin/lipopolysacchride-induced liver injury in rats.[Pubmed: 25978596]
    Isofuranodiene is a natural sesquiterpene rich occurring in Smyrnium olusatrum, a forgotten culinary herb which was marginalised after the domestication of the improved form of celery. Our recent data showed that Isofuranodiene inhibited the proliferation and induced apoptosis in cancer cells.
    METHODS AND RESULTS:
    In this study, we investigated its protective effect on d-galactosamine/lipopolysacchride (GalN/LPS)-induced liver injury in SD rats. Oral administration of Isofuranodiene (20 and 50 mg/kg) dramatically inhibited GalN/LPS-induced serum elevation of aspartate aminotransferase, alanine aminotransferase and malondialdehyde levels, and significantly ameliorated liver injury as evidenced by the histological improvement in H&E staining. Furthermore, Isofuranodiene treatment significantly inhibited GalN/LPS-induced mRNA expression of IL-1β, IL-6 and inducible nitric oxide synthase in liver tissues.
    CONCLUSIONS:
    The results from this study showed that Isofuranodiene protects GalN/LPS-induced liver injury in SD rats and suggested that it may be a potential functional food ingredient for the prevention and treatment of liver diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.6232 mL 23.116 mL 46.2321 mL 92.4642 mL 115.5802 mL
    5 mM 0.9246 mL 4.6232 mL 9.2464 mL 18.4928 mL 23.116 mL
    10 mM 0.4623 mL 2.3116 mL 4.6232 mL 9.2464 mL 11.558 mL
    50 mM 0.0925 mL 0.4623 mL 0.9246 mL 1.8493 mL 2.3116 mL
    100 mM 0.0462 mL 0.2312 mL 0.4623 mL 0.9246 mL 1.1558 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    莪术呋喃二烯酮; Furanodienone CFN92028 24268-41-5 C15H18O2 = 230.3 20mg QQ客服:2159513211
    蓬莪术环氧酮; Zederone CFN92616 7727-79-9 C15H18O3 = 246.3 20mg QQ客服:2159513211
    钓樟内酯; Linderalactone CFN99761 728-61-0 C15H16O3 = 244.29 20mg QQ客服:3257982914
    1,2-环氧-10(14)-呋喃吉玛烯-6-酮; 1,2-Epoxy-10(14)-furanogermacren-6-one CFN95214 383368-24-9 C15H18O3 = 246.3 10mg QQ客服:215959384
    (1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one; (1E)-3-methoxy-8,12-epoxygermacra-1,7,10,11-tetraen-6-one CFN95219 1393342-06-7 C16H20O3 = 260.3 5mg QQ客服:1413575084
    乌药醚内酯; Linderane CFN98175 13476-25-0 C15H16O4 = 260.28 20mg QQ客服:1148253675
    伪新乌药醚内酯; Pseudoneolinderane CFN91936 20082-45-5 C15H16O4 = 260.29 5mg QQ客服:2932563308
    二氢焦蓬莪术酮; Dihydropyrocurzerenone CFN91911 59462-26-9 C15H18O = 214.30 5mg QQ客服:215959384
    焦蓬莪术酮; Pyrocurzerenone CFN96169 20013-75-6 C15H16O = 212.3 20mg QQ客服:215959384
    Dehydrochromolaenin; Dehydrochromolaenin CFN96174 20013-76-7 C15H14O = 210.3 5mg QQ客服:1413575084

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