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  • 滨蒿內酯


    产品编号 CFN99314
    CAS编号 120-08-1
    分子式 = 分子量 C11H10O4 = 206.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Artemisia scoparia
    产品名称 产品编号 CAS编号 包装 QQ客服
    滨蒿內酯 CFN99314 120-08-1 10mg QQ客服:1148253675
    滨蒿內酯 CFN99314 120-08-1 20mg QQ客服:1148253675
    滨蒿內酯 CFN99314 120-08-1 50mg QQ客服:1148253675
    滨蒿內酯 CFN99314 120-08-1 100mg QQ客服:1148253675
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • ...
  • 生物活性
    Description: Scoparone is a phytoalexin with antifungal,anticoagulant, antianginal, hypolipidemic, vasorelaxant, immunosuppression, hepatoprotective,anti-allergic,antioxidant, and anti-inflammatory actions, it is used for the traditional treatment of neonatal jaundice. It inhibited the activities of PPARγ, STAT3, NADPH-oxidase 1, and the expression of ERK,NF-kB, JNK,PI3K. It augmented the expression of SOD1 and CAT.
    Targets: NF-kB | ERK | ROS | PI3K | STAT | PPAR | IL Receptor | TNF-α
    In vitro:
    Exp Cell Res. 2015 Feb 15;331(2):267-77.
    Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging.[Pubmed: 25576385]
    Scoparone, one of the bioactive components of Artemisia capillaris Thunb, has various biological properties including immunosuppressive, hepatoprotective, anti-allergic, anti-inflammatory, and antioxidant effects.
    This study aims at evaluating the anti-osteoporotic effect of scoparone and its underlying mechanism in vitro. Scoparone demonstrated potent cellular antioxidant capacity. It was also found that scoparone inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation and suppressed cathepsin K and tartrate-resistant acid phosphatase (TRAP) expression via c-jun N-terminal kinase (JNK)/extracellular signal-regulated kinase (ERK)/p38-mediated c-Fos-nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) signaling pathway. During osteoclast differentiation, the production of general reactive oxygen species (ROS) and superoxide anions was dose-dependently attenuated by scoparone. In addition, scoparone diminished NADPH (nicotinamide adenine dinucleotide phosphate) oxidase 1 (Nox1) expression and activation via the tumor necrosis factor receptor-associated factor 6 (TRAF6)-cSrc-phosphatidylinositol 3-kinase (PI3k) signaling pathway and prevented the disruption of mitochondrial electron transport chain system. Furthermore, scoparone augmented the expression of superoxide dismutase 1 (SOD1) and catalase (CAT).
    The overall results indicate that the inhibitory effect of scoparone on RANKL-induced osteoclast differentiation is attributed to the suppressive effect on ROS and superoxide anion production by inhibiting Nox1 expression and activation and protecting the mitochondrial electron transport chain system and the scavenging effect of ROS resulting from elevated SOD1 and CAT expression.in system and the scavenging effect of ROS resulting from elevated SOD1 and CAT expression.
    Food Chem. 2013 Nov 15;141(2):723-30.
    Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes.[Pubmed: 23790840]
    This study was performed to investigate the effect of scoparone on the differentiation of 3T3-L1 preadipocytes.
    Scoparone inhibited triglyceride (TG) accumulation in the mature adipocytes, evidenced by Oil-red O staining and intracellular quantification. Real time-PCR analysis showed that scoparone significantly down-regulated the mRNA expression of key adipogenic transcription factors, PPARγ, C/EBPα, compared with mature adipocytes. Scoparone appeared to reduce mRNA expression of SREBP1c and FAS being related to the late stage of adipogenesis. Furthermore, aP2 and CD36/FAT, as adipocyte-specific genes, were decreased in mature adipocytes by scoparone treatment. Moreover, scoparone inhibited the up-regulated expression of PPARγ target genes by rosiglitazone to near that observed in cells treated with GW9662. The luciferase assay revealed that scoparone negatively regulates the transcriptional activity of PPARγ. Chromatin immunoprecipitation assay also showed that participation of scoparone in the regulation of PPARγ.
    Collectively, scoparone has a PPARγ antagonic effect and suppresses differentiation through down-regulation of adipogenic genes by PPARγ inhibition in 3T3-L1 preadipocytes.
    Phytopathology, 1989, 78(12):1678-82.
    Accumulation of scoparone, a phytoalexin associated with resistance of citrus to Phytophthora citrophthora.[Reference: WebLink]

    Citrus species resistant and susceptible to Phytophthora citrophthora were compared for production of scoparone in the bark 1-8 days after inoculation with the pathogen. Concentrations of scoparone were higher (maximum 440 ug/g fr wt after 4 days) and increased more rapidly in the resistant species within 24 hr after inoculation. In the susceptible species the maximum concentration was 41.6 micrograms/g fr wt. The lesion length caused by P. citrophthora in citrus bark 4 days after inoculation was 2.5-5.0 mm in the resistant, compared with more than 11 mm in the susceptible.
    Scoparone inhibited mycelial growth of P. citrophthora and spore germination of six other phytopathogenic fungi in vitro. Radioactivity was incorporated into scoparone in infected citrus bark that had been treated with 14C-phenylalanine. Resistant citrus species, treated with the inhibitor aminooxyacetic acid (AOA) before inoculation, became susceptible to P. citrophthora.
    In vivo:
    Chem Pharm Bull (Tokyo). 1989 May;37(5):1297-9.
    The effect of scoparone, a coumarin derivative isolated from the Chinese crude drug Artemisiae capillaris flos, on the heart.[Pubmed: 2630096]

    In the present study, Scoparone isolated from Artemisia Capillaris Flos has been investigated to determine its pharmacological properties on the heart. Scoparone was found to cause the increase in coronary flow and heart rate, but did not affect cardiac output, left ventricular pressure or left ventricular work in the isolated perfused heart. Scoparone at 25 mg/kg and 50 mg/kg, p.o. had a marked inhibitory effect on the ST wave depression.
    Consequently it is suggested that Scoparone has antianginal action.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8497 mL 24.2483 mL 48.4966 mL 96.9932 mL 121.2415 mL
    5 mM 0.9699 mL 4.8497 mL 9.6993 mL 19.3986 mL 24.2483 mL
    10 mM 0.485 mL 2.4248 mL 4.8497 mL 9.6993 mL 12.1242 mL
    50 mM 0.097 mL 0.485 mL 0.9699 mL 1.9399 mL 2.4248 mL
    100 mM 0.0485 mL 0.2425 mL 0.485 mL 0.9699 mL 1.2124 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4-甲基瑞香素; 4-Methyldaphnetin CFN93089 2107-77-9 C10H8O4 = 192.17 5mg QQ客服:1413575084
    5,7-二羟基-4-甲基香豆素; 5,7-Dihydroxy-4-methylcoumarin CFN93090 2107-76-8 C10H8O4 = 192.17 5mg QQ客服:215959384
    6,7-二羟基香豆素; 6,7-Dihydroxycoumarin CFN99115 305-01-1 C9H6O4 = 178.14 20mg QQ客服:3257982914
    4-甲基七叶亭; 4-Methylesculetin CFN93058 529-84-0 C10H8O4 = 192.17 5mg QQ客服:2932563308
    秦皮甲素; Esculin CFN99114 531-75-9 C15H16O9 = 340.28 20mg QQ客服:215959384
    异莨菪亭; Isoscopoletin CFN97684 776-86-3 C10H8O4 = 192.17 20mg QQ客服:1413575084
    6-甲氧基香豆素-7-0-beta-D-吡喃葡萄糖苷; Magnolioside CFN90699 20186-29-2 C16H18O9 = 354.3 10mg QQ客服:3257982914
    东莨菪内酯; 莨菪亭; Scopoletin CFN97494 92-61-5 C10H8O4 = 192.2 20mg QQ客服:1413575084
    乙酸东莨菪素酯; Scopoletin acetate CFN98951 56795-51-8 C12H10O5 = 234.2 5mg QQ客服:3257982914
    6-甲氧基-7-异戊烯氧基香豆素; 7-O-Prenylscopoletin CFN92639 13544-37-1 C15H16O4 = 260.3 5mg QQ客服:3257982914





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