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  • Rosamultin

    Rosamultin

    Rosamultin
    产品编号 CFN89097
    CAS编号 88515-58-6
    分子式 = 分子量 C36H58O10 = 650.85
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Rosa rugosa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Rosamultin CFN89097 88515-58-6 1mg QQ客服:2159513211
    Rosamultin CFN89097 88515-58-6 5mg QQ客服:2159513211
    Rosamultin CFN89097 88515-58-6 10mg QQ客服:2159513211
    Rosamultin CFN89097 88515-58-6 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Hellenic Research Foundation (Greece)
  • Nanjing University of Chinese Medicine (China)
  • University of Illinois at Chicago (USA)
  • University of Toronto (Canada)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Universidad de La Salle (Mexico)
  • Korea Institute of Oriental Medicine (Korea)
  • University of Pretoria (South Africa)
  • Yale University (USA)
  • University of Vigo (Spain)
  • Florida A&M University (USA)
  • Utrecht University (Netherlands)
  • Ateneo de Manila University (Philippines)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2015, 22(14):1262-8
  • Phytomedicine.2015, 22(4):498-503
  • Am J Chin Med.2015, 30:1-22
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • J Pharm Biomed Anal2016, 118:183-194
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Mediators Inflamm. 2016, 2016:6189590
  • Biochem Pharmacol.2017, 130:10-20
  • Exp Parasitol.2017, 183:160-166
  • University of Central Lancashire2017, 20472
  • Pharm Biol.2017, 55(1):360-366
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • RSC Advances2017, 86
  • Int. J. of Food Properties2017, S108-S118
  • Nutrients.2018, 10(12)
  • Curr Eye Res.2018, 43(1):27-34
  • Primary and Industrial.2018, 52(11)
  • Clin Transl Oncol.2019, 10.1007
  • Industrial Crops and Products2019, 140:111612
  • Int J Mol Sci.2019, 20(16):E4015
  • Int J Mol Sci.2019, 21(1):E265
  • Int J Oncol.2019, 55(1):320-330
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • ...
  • 生物活性
    Description: Rosamultin has antioxidant, antiinflammatory/antinociceptive properties, it may protect against bromobenzene-induced hepatotoxicity through, at least in part, enhanced activity of epoxide hydrolase. Rosamultin has anti-human immunodeficiency virus (HIV) activity, it inhibited HIV-1 protease by 53% at a concentration of 100 microM.
    Targets: HIV | Immunology & Inflammation related
    In vitro:
    J Med Food. 2005 Spring;8(1):107-9.
    Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa.[Pubmed: 15857219 ]

    METHODS AND RESULTS:
    To identify substances with anti-human immunodeficiency virus (HIV) activity from plant sources, 12 extracts of Rosa family plants were screened for their inhibitory effects against HIV-1 protease. Of the extracts tested, the strongest inhibitory effects were observed in the root of Rosa rugosa and the leaves of Prunus sargentii, at a concentration of 100 microg/mL.
    CONCLUSIONS:
    Rosamultin isolated from the root of R. rugosa inhibited HIV-1 protease by 53% at a concentration of 100 microM.
    In vivo:
    Biol Pharm Bull. 2005 Jan;28(1):101-4.
    19Alpha-hydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa.[Pubmed: 15635171]
    To search for antiinflammtory 19alpha-hydroxyursane-type triterpenoids, the MeOH extract of the roots of Rosa rugosa (Rosaceae) was fractionated.
    METHODS AND RESULTS:
    The active fraction of the EtOAc extract was hydrolyzed in alkaline solution to give a hydrolyzed fraction. Both extracts showed antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Repeated chromatography of the EtOAc extract on both silica gel and octadecylsilane columns led to the isolation of kaji-ichigoside F1 (1, euscaphic acid 28-O-glucoside) and Rosamultin (2, tormentic acid 28-O-glucoside). The hydrolyzed fraction was also subjected to silica gel column and octadecylsilane column chromatography to produce euscaphic acid (3) and tormentic acid (4). The potencies were observed in the following order: 4>3>2>1.
    CONCLUSIONS:
    These results suggest that 19alpha-hydroxyursane-type triterpenoids are responsible for the antiinflammatory/antinociceptive action of R. rugosa roots.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5365 mL 7.6823 mL 15.3645 mL 30.729 mL 38.4113 mL
    5 mM 0.3073 mL 1.5365 mL 3.0729 mL 6.1458 mL 7.6823 mL
    10 mM 0.1536 mL 0.7682 mL 1.5365 mL 3.0729 mL 3.8411 mL
    50 mM 0.0307 mL 0.1536 mL 0.3073 mL 0.6146 mL 0.7682 mL
    100 mM 0.0154 mL 0.0768 mL 0.1536 mL 0.3073 mL 0.3841 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    刺梨苷 F1; Kaji-ichigoside F1 CFN89311 95298-47-8 C36H58O10 = 650.85 5mg QQ客服:2932563308
    Rosamultin; Rosamultin CFN89097 88515-58-6 C36H58O10 = 650.85 10 mg QQ客服:1148253675
    苦莓苷F1; Niga-ichigoside F1 CFN91060 95262-48-9 C36H58O11 = 666.9 5mg QQ客服:1148253675
    山香醇酸糖苷F1; Suavissimoside F1 CFN91067 95645-51-5 C36H56O12 = 680.8 5mg QQ客服:215959384
    地榆皂苷I; Ziyuglycoside I CFN98464 35286-58-9 C41H66O13 = 767.0 20mg QQ客服:1148253675
    3-氧代坡模酸; 3-Oxopomolic acid CFN92574 13849-90-6 C30H46O4 = 470.7 5mg QQ客服:1148253675
    3-氧代坡模酸甲酯; 3-Oxopomolic acid methyl ester CFN92820 14440-23-4 C31H48O4 = 484.7 5mg QQ客服:2159513211
    (3beta,6beta)-3,6,19-三羟基乌苏-12-烯-28-酸; Uncaric acid CFN99349 123135-05-7 C30H48O5 = 488.7 5mg QQ客服:3257982914
    6,19-二羟基乌苏-12-烯-3-氧代-28-酸; 6,19-Dihydroxyurs-12-en-3-oxo-28-oic acid CFN99892 194027-11-7 C30H46O5 = 486.7 5mg QQ客服:3257982914
    地榆皂苷II; Ziyuglycoside II CFN98465 35286-59-0 C35H56O8 = 604.8 20mg QQ客服:3257982914

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